Name: intense pulsed light for the treatment of dry eye owing to meibomian gland dysfunction
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Description: Watch this Scientific Journal Video about Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction at JoVE.com

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在任何学习程序之前, 所有参与者都得到了口头和书面的知情同意。这项研究的议定书是根据《赫尔辛基宣言》进行的, 并得到了地方机构审查委员会的批准。
1. 自动眼表面处理
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无创断裂时间 (但) 和脂质层厚度 (LLT) 评估
	<ol>
<li>在连接到设备的计算机上安装 sbm Sistemi 的 "i. c. p." 程序。</li>
		<li>将设备应用在滑灯上。</li>
		<li>打开应用程序并插入患者的数据。</li>
		<li>选...

<ol>
	<li>Schaumberg, D. A., Dana, R., Buring, J. E., Sullivan, D. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Prevalence+of+dry+eye+disease+among+US+men:+estimates+from+the+Physicians'+Health+Studies.">Prevalence of dry eye disease among US men: estimates from the Physicians' Health Studies.</a> Arch Ophthalmol. 127 (6), 763-768 (2009).</li><li>Craig, J. P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=TFOS+DEWS+II+Definition+and+Classification+Report.">TFOS DEWS II Definition and Classification Report.</a> Ocul Surf. 15 (3), 276-283 (2017).</li><li>Buchholz, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Utility+assessment+to+measure+the+impact+of+dry+eye+disease.">Utility assessment to measure the impact of dry eye disease.</a> Ocul Surf. 4 (3), 155-161 (2006).</li><li>Uchino, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dry+eye+disease+and+work+productivity+loss+in+visual+display+users:+the+Osaka+study.">Dry eye disease and work productivity loss in visual display users: the Osaka study.</a> Am J Ophthalmol. 157 (2), 294-300 (2014).</li><li>Schaumberg, D. A., Nichols, J. J., Papas, E. B., Tong, L., Uchino, M., Nichols, K. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+international+workshop+on+meibomian+gland+dysfunction:+report+of+the+subcommittee+on+the+epidemiology+of,+and+associated+risk+factors+for,+MGD.">The international workshop on meibomian gland dysfunction: report of the subcommittee on the epidemiology of, and associated risk factors for, MGD.</a> Invest Ophthalmol Vis Sci. 52 (4), 1994-2005 (1994).</li><li>Baudouin, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Revisiting+the+vicious+circle+of+dry+eye+disease:+a+focus+on+the+pathophysiology+of+meibomian+gland+dysfunction.">Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction.</a> Br J Ophthalmol. 100 (3), 300-306 (2016).</li><li>Knop, E., Knop, N., Millar, T., Obata, H., Sullivan, D. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+international+workshop+on+meibomian+gland+dysfunction:+report+of+the+subcommittee+on+anatomy,+physiology,+and+pathophysiology+of+the+meibomian+gland.">The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland.</a> Invest Ophthalmol Vis Sci. 52 (4), 1938-1978 (1938).</li><li>Bron, A. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=TFOS+DEWS+II+pathophysiology+report.">TFOS DEWS II pathophysiology report.</a> Ocul Surf. 15 (3), 438-510 (2017).</li><li>Qiao, J., Yan, X. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Emerging+treatment+options+for+meibomian+gland+dysfunction.">Emerging treatment options for meibomian gland dysfunction.</a> Clin Ophthalmol. 7, 1797-1803 (2013).</li><li>Papageorgiou, P., Clayton, W., Norwood, S., Chopra, S., Rustin, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Treatment+of+rosacea+with+intense+pulsed+light:+significant+improvement+and+long-lasting+results.">Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results.</a> Br J Dermatol. 159 (3), 628-632 (2008).</li><li>Toyos, R., McGill, W., Briscoe, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intense+pulsed+light+treatment+for+dry+eye+disease+due+to+meibomian+gland+dysfunction;+a+3-year+retrospective+study.">Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study.</a> Photomed Laser Surg. 33 (1), 41-46 (2015).</li><li>Vora, G. K., Gupta, P. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intense+pulsed+light+therapy+for+the+treatment+of+evaporative+dry+eye+disease.">Intense pulsed light therapy for the treatment of evaporative dry eye disease.</a> Curr Opin Ophthalmol. 26 (4), 314-318 (2015).</li><li>Liu, R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Analysis+of+Cytokine+Levels+in+Tears+and+Clinical+Correlations+After+Intense+Pulsed+Light+Treating+Meibomian+Gland+Dysfunction.">Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction.</a> Am J Ophthalmol. 183, 81-90 (2017).</li><li>Goldberg, D. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Current+Trends+in+Intense+Pulsed+Light.">Current Trends in Intense Pulsed Light.</a> J Clin Aesthet Dermatol. 5 (6), 45-53 (2012).</li><li>Dell, S. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intense+pulsed+light+for+evaporative+dry+eye+disease.">Intense pulsed light for evaporative dry eye disease.</a> Clin Ophthalmol. 11, 1167-1173 (2017).</li><li>Pult, H., Riede-Pult, B. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Non-contact+meibography:+keep+it+simple+but+effective.">Non-contact meibography: keep it simple but effective.</a> Cont Lens Anterior Eye. 35 (2), 77-80 (2012).</li><li>Fitzpatrick, T. B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+validity+and+practicality+of+sun-reactive+skin+types+I+through+VI.">The validity and practicality of sun-reactive skin types I through VI.</a> Arch Dermatol. 124 (6), 869-871 (1988).</li><li>Raulin, C., Greve, B., Grema, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=IPL+technology:+a+review.">IPL technology: a review.</a> Lasers Surg Med. 32 (2), 78-87 (2003).</li><li>Toyos, R., Buffa, C. M., Youngerman, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Case+report:+Dry-eye+symptoms+improve+with+intense+pulsed+light+treatment.">Case report: Dry-eye symptoms improve with intense pulsed light treatment.</a> Eye World News Magazine. , (2005).</li><li>Jiang, X., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Evaluation+of+the+Safety+and+Effectiveness+of+Intense+Pulsed+Light+in+the+Treatment+of+Meibomian+Gland+Dysfunction.">Evaluation of the Safety and Effectiveness of Intense Pulsed Light in the Treatment of Meibomian Gland Dysfunction.</a> J Ophthalmol. , (2016).</li><li>Albietz, J. M., Schmid, K. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intense+pulsed+light+treatment+and+meibomian+gland+expression+for+moderate+to+advanced+meibomian+gland+dysfunction.">Intense pulsed light treatment and meibomian gland expression for moderate to advanced meibomian gland dysfunction.</a> Clin Exp Optom. 101 (1), 23-33 (2018).</li><li>Gupta, P. K., Vora, G. K., Matossian, C., Kim, M., Stinnett, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Outcomes+of+intense+pulsed+light+therapy+for+treatment+of+evaporative+dry+eye+disease.">Outcomes of intense pulsed light therapy for treatment of evaporative dry eye disease.</a> Can J Ophthalmol. 51 (4), 249-253 (2016).</li><li>Dell, S. J., Gaster, R. N., Barbarino, S. C., Cunningham, D. N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Prospective+evaluation+of+intense+pulsed+light+and+meibomian+gland+expression+efficacy+on+relieving+signs+and+symptoms+of+dry+eye+disease+due+to+meibomian+gland+dysfunction.">Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction.</a> Clin Ophthalmol. 11, 817-827 (2017).</li><li>Vegunta, S., Patel, D., Shen, J. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Combination+Therapy+of+Intense+Pulsed+Light+Therapy+and+Meibomian+Gland+Expression+(IPL/MGX)+Can+Improve+Dry+Eye+Symptoms+and+Meibomian+Gland+Function+in+Patients+With+Refractory+Dry+Eye:+A+Retrospective+Analysis.">Combination Therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) Can Improve Dry Eye Symptoms and Meibomian Gland Function in Patients With Refractory Dry Eye: A Retrospective Analysis.</a> Cornea. 35 (3), 318-322 (2016).</li><li>Roy, N. S., Wei, Y., Kuklinski, E., Asbell, P. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+Growing+Need+for+Validated+Biomarkers+and+Endpoints+for+Dry+Eye+Clinical+Research.">The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research.</a> Invest Ophthalmol Vis Sci. 58 (6), BIO1-BIO19 (2016).</li><li>Giannaccare, G., Vigo, L., Pellegrini, M., Sebastiani, S., Carones, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ocular+Surface+Workup+With+Automated+Noninvasive+Measurements+for+the+Diagnosis+of+Meibomian+Gland+Dysfunction.">Ocular Surface Workup With Automated Noninvasive Measurements for the Diagnosis of Meibomian Gland Dysfunction.</a> Cornea. , (2018).</li><li>Craig, J. P., Chen, Y. H., Turnbull, P. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Prospective+trial+of+intense+pulsed+light+for+the+treatment+of+meibomian+gland+dysfunction.">Prospective trial of intense pulsed light for the treatment of meibomian gland dysfunction.</a> Invest Ophthalmol Vis Sci. 56 (3), 1965-1970 (1965).</li><li>Meadows, J. F., Ramamoorthy, P., Nichols, J. J., Nichols, K. K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Development+of+the+4-3-2-1+meibum+expressibility+scale.">Development of the 4-3-2-1 meibum expressibility scale.</a> Eye Contact Lens. 38 (2), 86-92 (2012).</li><li>Finis, D., Hayajneh, J., K&#246;nig, C., Borrelli, M., Schrader, S., Geerling, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Evaluation+of+an+automated+thermodynamic+treatment+(LipiFlow&#174;)+system+for+meibomian+gland+dysfunction:+a+prospective,+randomized,+observer-masked+trial.">Evaluation of an automated thermodynamic treatment (LipiFlow&#174;) system for meibomian gland dysfunction: a prospective, randomized, observer-masked trial.</a> Ocul Surf. 12 (2), 146-154 (2014).</li><li>Yin, Y., Liu, N., Gong, L., Song, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Changes+in+the+Meibomian+Gland+After+Exposure+to+Intense+Pulsed+Light+in+Meibomian+Gland+Dysfunction+(MGD)+Patients.">Changes in the Meibomian Gland After Exposure to Intense Pulsed Light in Meibomian Gland Dysfunction (MGD) Patients.</a> Curr Eye Res. 43 (3), 308-313 (2018).</li><li>Guilloto Caballero, S., Garc&#237;a Madrona, J. L., Colmenero Reina, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effect+of+pulsed+laser+light+in+patients+with+dry+eye+syndrome.">Effect of pulsed laser light in patients with dry eye syndrome.</a> Arch Soc Esp Oftalmol. 92 (11), 509-515 (2017).</li></ol>

强脉冲光器件采用氙气填充闪光灯, 在从可见光 (515 nm) 到红外 (1200 nm) 18 的宽波长光谱中产生多色非相干光的非激光高强度脉冲.光能脉冲由手机的头部通过蓝宝石或石英块释放, 因此直接应用于皮肤表面。
IPL 系统的作用机理是基于选择性热摩利的原理, 根据该原理, 某些目标, 称为色差, 能够吸收, 然后将光转化为热能12。
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干眼症 (DED) 是一种越来越常见的疾病, 也是临床去看眼科医生1 的最常见原因之一。受 DED 影响的患者所抱怨的主要症状不同于不同等级的发红和眼部不适, 以及慢性异物感觉、刺痛、灼烧、瘙痒、过度撕裂、疼痛、反复感染和短暂视觉干扰2。DED 对患者生活质量的影响与中度至重度心绞痛或透析治疗引起的影响被比较 3, 并与日常活动的限制和工作效率的丧失有关4。最近由 TFOS DEWS II 制定的干眼症定义突出了其多因素性质, 因为不同的复杂和异质性改变在疾病的发生和维持中发挥着重要作用2。
绝大多数干眼症是由所谓的 "蒸发性" 亚型引起的, 这种亚型主要是由 meibomian 腺功能障碍 (MGD) 引起的, 这种情况影响到世界特定地区多达70% 的人口5。梅博米安腺功能障碍是由位于上、下眼睑内的美波米安腺体的慢性改变引起的。本病的特点是腺体外管过度角化, 孔部阻塞不足, 功能不正常, 产生泪膜的外脂层, 导致撕裂不稳定 6, 7,8。
目前, 有几种不同的治疗策略, 旨在阻断干眼症的恶性循环, 主要包括抗生素、消炎药、眼睑卫生、温压和泪液9.然而, 这些疗法是慢性的, 往往只能提供部分或短期的症状缓解, 并伴随着随后的依从性问题。因此, 具有较高疗效和耐受性的新型治疗方法是可取的。近年来, 强脉冲光 (IPL) 治疗已被广泛用于皮肤病学治疗各种皮肤病, 如痤疮, 酒渣鼻, 毛细血管扩张和血管和色素病变 (如血管瘤, 静脉畸形,港酒污渍)10。当光线应用于皮肤时, 它被色素结构 (如血细胞和定位酶) 吸收, 随后产生的热量会凝固并破坏异常的血管11。近年来, 该技术在 FD 治疗的眼科领域得到了应用。有几种机制可以解释该程序的治疗效果。首先, IPL 治疗作用于诱导眼睑皮肤浅表血管和毛细血管扩张的热凝和选择性消融。此外, 该程序减少释放炎症介质和泪液细胞因子的水平, 这可能会促进压气腺末端导管 12,13的角化。其次, 将光能转化为热量, 导致美波米腺分泌物的升温和液化, 随后融化和流出减少了 11,14。最近, 其他机制, 如增强胶原蛋白合成和结缔组织重塑, 减少皮肤上皮细胞的周转, 以及调节细胞炎症标志物也被假设为15。
在这项研究中, 我们描述了最近商业化的 IPL 装置的使用和治疗效果, 该装置是专门为治疗 MGD 而开发的, 在这种装置中, IPL 的发射在多个校准和均质的多色序列中得到了 "调节"。顺序脉冲。因此, 本研究的目的是详细描述治疗过程, 以便将其传播到科学医学界, 使眼科医生有机会扩大目前用于 MGD 治疗的军备调查室。

<table border="0" cellpadding="0" cellspacing="0" width="1004">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:187px;">I.C.P. Tearscope</td>
			<td style="width:240px;">SBM Sistemi, Turin, Italy</td>
			<td style="width:103px;">1340864/R</td>
			<td style="width:475px;">Device for noninvasvive break-up time and lipid layer thickness evaluation</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:187px;">I.C.P. MGD</td>
			<td style="width:240px;">SBM Sistemi, Turin, Italy</td>
			<td style="width:103px;">15006</td>
			<td>Device performing infrared meibomography and meibomian gland loss evaluation</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:187px;">TearLab Osmolarity System</td>
			<td>TearLab Corporation, San Diego, CA, USA</td>
			<td style="width:103px;">83861QW</td>
			<td>Device for the measurement of tear osmolarity&#160;</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:187px;">E&#62;Eye</td>
			<td style="width:240px;">E-Swin, Paris, France</td>
			<td style="width:103px;"></td>
			<td>Intense pulsed regulated light treatment device</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:187px;">BM 900 Slit Lamp Biomioscropy</td>
			<td style="width:240px;">Haag-Streit, Koeniz, Switzerland</td>
			<td style="width:103px;">BM 900</td>
			<td>Slit Lamp Biomiscroscopy</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:187px;">Tobradex eye drops</td>
			<td style="width:240px;">Alcon Inc., Fort Worth, TX, USA</td>
			<td style="width:103px;">S01CA01</td>
			<td>Eye drops instilled immediately after the procedure in office</td>
		</tr>
	</tbody>
</table>

intense pulsed light for the treatment of dry eye owing to meibomian gland dysfunction

干眼症 (DED) 是一种越来越常见的疾病, 也是患者最常见的投诉之一。绝大多数的 DED 是由所谓的 "蒸发" 亚型引起的, 主要是由 meibomian 腺体功能障碍 (MGD) 引起的。强脉冲光 (IPL) 器件采用波长范围广 (515-1200 nm) 的高强度多色光脉冲。IPL 治疗在皮肤科领域已经使用多年, 然后应用于眼科治疗 MGD。最近, 一种采用 IPL 的新设备是专门为眼周应用而设计的。该程序确定眼睑皮肤浅血管和毛细血管扩张的热选择性凝血和消融, 减少炎症介质和泪液细胞因子水平的释放, 并改善美波皮腺流出。IPL 治疗是无创的, 易于执行, 仅持续几分钟, 可以在办公室环境中进行。在本研究中, 19名患者接受了 3次 IPL 治疗。治疗后, 平均无创破碎时间和脂质层厚度等级均显著提高, 分别是由于泪膜稳定性和质量的提高。相反, 对于美波米腺损失和撕裂渗透性, 没有发现统计学上的显著变化。此外, 绝大多数接受治疗的患者 (17/19; 占总数的 99.5%) 认为他们的眼部不适症状在 IPL 治疗后有所改善。虽然 IPL 治疗提供了改善眼表参数和眼部不适症状后, 一个周期的三个疗程, 定期反复治疗, 以保持持久性, 在其有益的时间影响。

在2016年9月至2017年6月期间, 19名患者 (7名男性和12名女性, 平均年龄39.3±7.0 岁) (平均±标准偏差) 接受了 IPL 治疗。在第三次 IPL 治疗后 15天, 非侵入性但从7.6±0.6 秒显著增加到9.8±0.7 秒 (平均值的平均±标准误差) (p = 0.017), 而 llt 等级从2.3±0.1 ±0.3 (p = 0.00 3) 显著提高。Mgl 和撕裂渗透性没有统计学上的显著变化 (23.9±3.6% 对25.4±2.6% 和 304.5±2.4 mω/l 对 3006±2.4 mω/l; 始终p<...

Watch this Scientific Journal Video about Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction at JoVE.com

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

干眼症是一种越来越常见的疾病, 严重损害患者的生活质量。最近, 一种新的设备使用强脉冲光, 专门为眼周区域设计, 已被证明, 以改善泪膜稳定性和眼不适症状干眼症, 由于美波米腺功能障碍。

梅博米安腺体功能障碍治疗干眼症的强脉冲光

Dry eye disease (DED) is an increasingly common condition and one of the most common complaints of patients. The vast majority of DED is caused by the ...

美博米腺功能障碍通常由慢性疗法管理，通常只提供部分或短期缓解干眼症状。强调节脉冲光装置发出多种多色光脉冲，加热眼睑皮肤，刺激美波米腺，减少抗炎介质和撕裂细胞因子的释放。打开 SBM .C的 I.P.程序，打开连接到设备的计算机上。输入患者的数据，并在菜单中选择适当的检查。指示患者将下巴和额头放在带仪器的狭缝灯上的正确位置，进行非侵入性 BUT 检查。非侵入性但后，检查脂层厚度。对于美博米腺损失评估，选择美博米腺检查。使用棉签轻轻擦拭下眼睑，获得下眼睑内部分的红外图像，以获得美博尼腺的高质量图像。在触摸屏上绘制眼睑区域的边缘，然后单击以填充该区域。系统将自动计算美博尼腺面积相对于眼睑总面积的百分比。对于强烈的脉冲光治疗，请舒适地让患者坐下，然后按下控制单元上的启动按钮以激活设备。要选择治疗美博米腺功能障碍，请按相应的液晶触摸屏按钮，并使用上下箭头选择所需的治疗能量水平。按刻度确认选择，然后按六个图标一个一个来验证六个安全功能。按刻度以确认该过程完全安全执行，然后再次按刻度以启动设备。当设备准备好治疗时，将护目镜放在患者的眼睛上，并戴上安全眼镜。从鼻子边缘到寺庙，在患者下眼睑下的皮肤上涂抹至少一厘米厚的光学凝胶。从中央单元上取下设备手提件，轻轻将手头与要处理区域的皮肤直接接触。按下手提上的启动按钮，发出单个处理强烈的脉冲光脉冲，然后沿着凝胶处理区域在尽可能靠近下眼睑边缘处的四个额外的强脉冲光脉冲。应用最后一个脉冲后，轻轻从处理的皮肤区域取出光学凝胶，并在两眼眼睑上进行热压缩两到三分钟。在这项研究中，19名患者接受了强烈的脉冲光。第三次治疗期后15天，非侵入性破裂时间显著增加，脂层厚度等级明显改善。未观察到梅博米腺丧失的统计显著变化，而泪性在治疗后呈下降趋势。17名患者在治疗后表现出眼部不适症状的改善，与脂层厚度的改善结果直接相关，对强烈的脉冲光治疗作出反应。在受梅博米腺功能障碍影响的患者中，密集调节脉冲光治疗似乎有效改善干眼体和症状。每六至八个月可能需要定期重复治疗，在三次启动后，才能在一段时间中保持手术的好处。

Research

JoVE Journal

Medicine

The Measurement and Treatment of Suppression in Amblyopia

测量和制止在弱视治疗

Amblyopia, a developmental disorder of the visual cortex, is one of the leading causes of visual dysfunction in the working age population. Current ...

科研

医学

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Goeckerman方案用于治疗中度至重度牛皮癣

Psoriasis is a  chronic, immune-mediated inflammatory skin disease affecting approximately 2-3%  of the population. The Goeckerman regimen consists of ...

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

在耐药性颞叶癫痫患者卵圆孔电极记录的网络分析

Approximately 30% of epilepsy patients are refractory to antiepileptic drugs. In these cases, surgery is the only alternative to eliminate/control ...

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

分离脂肪衍生的再生细胞用于治疗根治性前列腺切除术后的勃起功能障碍

Stem cells are used in many research areas within regenerative medicine in part because these treatments can be curative rather than symptomatic. Stem ...

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies

由康卡纳林注射到乳原区引起的水性干眼病的兔子模型：药物功效研究的应用

Dry eye disease (DED), a multifactorial inflammatory disease of the ocular surface, affects 1 in 6 humans worldwide with staggering implications for ...

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

在兔子中使用完全的白眼切除术建立严重干眼模型

Dry eye disease (DED) is a complex disease with multiple etiologies and variable symptoms, having ocular surface inflammation as its key pathophysiologic ...

Intratracheal Administration of Dry Powder Formulation in Mice

小鼠干粉配方的内经管理

In the development of inhalable dry powder formulations, it is essential to evaluate their biological activities in preclinical animal models. This paper ...

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

富血小板血浆裂解物用于治疗眼表疾病

Various ocular surface diseases are treated with blood-derived eye drops. Their use has been introduced in clinical practice because of their metabolite ...

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

COVID-19期间干眼症患者结膜充血分级与眼表疾病指数评分的比较

The incidence of dry eye syndrome (DES) has increased due to wearing masks, utilizing digital devices, and working remotely during the pandemic. A survey ...

Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations (Video) | JoVE

皮内微透析：研究人类微血管功能障碍新机制的方法

The cutaneous vasculature is an accessible tissue that can be used to assess microvascular function in humans. Intradermal microdialysis is a minimally ...