Glioblastoma multiforme remains the most frequent and aggressive primary brain tumor in adults. Despite aggressive treatments based on surgery followed by radio and chemotherapy, GBM is associated with an extremely poor prognosis and a median surv
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Here, we present a protocol for the preparation and the stereotaxic administration of allogeneic human lymphocytes in immunodeficient mice carrying orthotopic human primary brain tumors. This study provides a proof-of-concept for both the feasibility and the antitumor efficacy of intrabrain-delivered cellular immunotherapies.