Many BioMEM devices, such as microfluidic channels, are fabricated using the soft lithography technique. Here, a microscale pattern is replicated by curing an elastomeric polymer over the 3D structure. These polymeric structures are then used to create a wide range of devices, ranging from microfluidic channels for biosensing applications to microscale bioreactors for the visualization of micro-colonies.

This video introduces photolithography and demonstrates the technique in the laboratory. Then, some applications of the technique and how the structures are used in the bioengineering field are examined.