Name: automated, long-term behavioral assay for cognitive functions in multiple genetic models of alzheimer's disease, using intellicage
Uploaded: 2018-08-04T15:00:00
Description: Watch this Scientific Journal Video about Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage at JoVE.com

Vi takker Reiko Ando for hendes hjælp i fotografere materialer. Denne forskning blev støttet af licensbetaling for sonderende forskning (JSP'ER KAKENHI Grant nummer 16K 15196).

Alle procedurerne, der blev godkendt af det institutionelle animal care og bruge udvalget, og de blev udført ifølge RIKEN hjernen Science Institutes retningslinjer for dyreforsøg.
1. indstilling apparater
Bemærk: En oversigt over automatiseret hjem-bur overvågningssystemet er vist i figur 1. Hvert system (39 cm x 58 cm x 21 cm) indeholder en mikroprocessor, og fire hjørne kamre, hver har to vandflasker og en ring antenne til påvisn...

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T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Habituation+and+sensitization:+new+thoughts+about+old+ideas.">Habituation and sensitization: new thoughts about old ideas.</a> Animal Behaviour. 120, 255-262 (2016).</li><li>Endo, T., Maekawa, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Automated+test+of+behavioral+flexibility+in+mice+using+a+behavioral+sequencing+task+in+IntelliCage.">Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage.</a> Behavioural brain research. 221 (1), 172-181 (2011).</li><li>Voikar, V., Colacicco, G., Gruber, O., Vannoni, E., Lipp, H. -. P., Wolfer, D. 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Dette papir beskriver den metode, ved hjælp af den automatiserede hjem-bur overvågningssystem for langsigtet kognitive og adfærdsmæssige assays i genetisk modificerede AD modeller. Den mest kritiske trin er implantation af transponder i den relevante position. Før du udfører implantation, sikre at udløbsdatoen af transponderen ikke er overskredet. Det andet vigtige punkt er at kontrollere funktion af systemet dagligt, især som et mindre problem kan efterfølgende blive en mere alvorlig i løbet af undersøgelsen ...

Udvikling af dyremodeller for neuronal sygdom i det sidste årti har givet en mekanistisk forståelse af deres grundlag og for at fremme de terapeutiske fremskridt1,2,3. Anvendelse af en høj overførselshastighed adfærdsmæssige test batteri i genetiske dyremodeller er en heuristisk forskningsværktøj til at undersøge de underliggende mekanismer af menneskelige sygdomme og identifikation af drug behandlingsformer. Forskning test batterier tilpasset til langsigtet observation af aldring og/eller demens modeller har traditionelt tvunget laboratorier at indtage store mængder af specialiseret arbejdskraft og tid. Et hjem-bur overvågningssystem ville være en omkostningseffektiv strategi, da det vil reducere udgifterne til adfærdsmæssige observation af mennesker. Nogle forskerhold har udviklet automatiseret vision-baserede værktøjer, der kan hjælpe adfærdsmæssige fænotyper af et enkelt individ i et lille hjem bur4,5,6. Imidlertid begrænser sådanne metoder social interaktion, størrelsen af testmiljøer og sorten af adfærdsmæssige foranstaltninger, der omfatter kognitive funktioner. IntelliCage er en anden generations hjem-bur overvågning system designet til at udføre forskellige kognitive opgaver i en social hjem bur. Vigtigere, denne metode kan eliminere daglige håndtering at gør det muligt for os at udføre langsigtet adfærdsmæssige overvågning med vurdering af kognitive funktioner, og det kan fjerne krav til specialiseret praktiske håndtering, og aktiverer meget reproducerbare data erhvervelse7. Her beskriver vi de langsigtede fænotyper og validering i genetiske musemodeller af Alzheimers sygdom (AD) som er blevet genereret seneste8,9,10 ved hjælp af automatiserede hjem-bur overvågning system. En test batteri, som omfattede vurderinger af rumlige læring og udøvende funktioner, blev gentagne gange udført på flere alder point (9-12 og 14-17 måneder gammel). Dette aldersbetinget fænotyper tillod os at identificere gener flygtig eller permanent påvirkning af forskellige kognitive aspekter. Vi fandt, at nogle AD modeller viste både forbigående og permanent fænotyper af flere kognitive aspekter testet i den langsigtede analyse ved hjælp af den automatiserede hjem-bur monitoring system10. Således, den automatiseret undersøgelse ved hjælp af hjem-bur overvågningssystem er gavnlig og omkostningseffektiv for langsigtet adfærdsmæssige fænotyper og validering i forskellige modeller for kognitiv dysfunktion.

<table>
	<tbody>
		<tr>
			<td>IntelliCage</td>
			<td>TSE Systems</td>
			<td>-</td>
			<td>Parchased in 2011 or later</td>
		</tr>
		<tr>
			<td>PC</td>
			<td>Dell</td>
			<td>Inspiron 580s</td>
			<td>-</td>
		</tr>
		<tr>
			<td>Display</td>
			<td>Dell</td>
			<td>SI75T-WL</td>
			<td>-</td>
		</tr>
		<tr>
			<td>ALPHA-dri</td>
			<td>Shepherd Specialty Papers</td>
			<td>-</td>
			<td>Standard bedding</td>
		</tr>
		<tr>
			<td>Aron Alpha (Krasy Glue) 2g</td>
			<td>Toagosei (Krasy Glue)</td>
			<td>#04612</td>
			<td>Cyanoacrylates for gluing magnet and blak arm</td>
		</tr>
		<tr>
			<td>Handheld Transponder Reader</td>
			<td>BTS-ID</td>
			<td>R-560</td>
			<td>Transponder reader, which reads both Trovan and DataMars</td>
		</tr>
		<tr>
			<td>Transponder</td>
			<td>DataMars</td>
			<td>T-VA, T-VAS, or another series</td>
			<td>Basic package of transponders and implanters</td>
		</tr>
		<tr>
			<td>Diamond Grip Plus</td>
			<td>Ansel Microflex</td>
			<td>DGP-INT-M</td>
			<td>Experimental glove</td>
		</tr>
		<tr>
			<td>Isoflurane</td>
			<td>Pfizer</td>
			<td>1119701G1092</td>
			<td>-</td>
		</tr>
		<tr>
			<td>Vaporizer for small animals</td>
			<td>DS Pharma Biomedical</td>
			<td>SF-B01</td>
			<td>Facemask included</td>
		</tr>
		<tr>
			<td>Neo-Medrol</td>
			<td>Pfizer</td>
			<td>006472-001</td>
			<td>Eye ointment</td>
		</tr>
		<tr>
			<td>Ethanol (70%)</td>
			<td>-</td>
			<td>-</td>
			<td>-</td>
		</tr>
		<tr>
			<td>Excel</td>
			<td>Microsoft</td>
			<td>00202-51382-15524-AA928</td>
			<td>For data analysis</td>
		</tr>
	</tbody>
</table>

automated, long-term behavioral assay for cognitive functions in multiple genetic models of alzheimer's disease, using intellicage

Flere faktorer – såsom aldring og gener – er ofte forbundet med kognitiv tilbagegang. Genetisk modificerede musemodeller af kognitiv tilbagegang, såsom Alzheimers sygdom (AD), er blevet et lovende redskab til at belyse de underliggende mekanismer og fremme de terapeutiske fremskridt. Et vigtigt skridt er validering og karakterisering af forventede adfærdsmæssige abnormitet i modeller for annonce, kognitiv tilbagegang. De langsigtede adfærdsmæssige undersøgelser af forsøgsdyr at studere effekten af aldrende efterspørgsel betydelig indsats fra forskere. IntelliCage systemet er en høj overførselshastighed og omkostningseffektiv test batteri til mus, der eliminerer behovet for daglige menneskelige håndtering. Her, beskriver vi hvordan systemet udnyttes i den langsigtede fænotyper af genetiske Alzheimers sygdom model, specielt med fokus på de kognitive funktioner. Eksperimentet beskæftiger gentagne batteri af tests for at vurderer rumlige læring og udøvende funktioner. Denne omkostningseffektive aldersbetinget fænotyper tillader os at identificere gener flygtig eller permanent påvirkning af forskellige kognitive aspekter.

I vores tidligere undersøgelse, blev aldersbetinget kognitiv underskud i AD modeller opdaget af eksperimenter ved hjælp af den automatiserede hjem-bur monitoring system10. Deres præstation for AD modeller i PP var intakt i både unge voksne og ældre emner; dog performance i PPR var betydeligt og gradvis forringet (figur 6). Det er også vigtigt at overholde generelle adfærd eller angst i fasen for tilpasning, fordi sådanne træk ...

Watch this Scientific Journal Video about Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage at JoVE.com

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Dette papir beskriver en protokol for kognitive vurderinger for genetiske modeller af Alzheimers sygdom ved hjælp af det IntelliCage system, som er en høj overførselshastighed automatiseret adfærdsmæssige overvågningssystem med operant betingning.

Automatiseret, langsigtede adfærdsmæssige Assay for kognitive funktioner i flere genetiske modeller af Alzheimers sygdom, ved hjælp af IntelliCage

Multiple factors&#8212;such as aging and genes&#8212;are frequently associated with cognitive decline. Genetically modified mouse models of cognitive ...

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The open field activity monitoring system comprehensively assesses locomotor and behavioral activity levels of mice. It is a useful tool for assessing ...

Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach

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Mouse is the preferred model organism for testing drugs designed to increase sociability. We present a method to quantify mouse sociability in which the ...

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Vurdering af Social Cognition i ikke-menneskelige primater Ved hjælp af en netværk af edb Automated Learning Device (ALDM) Test Systems

Fagot &#38; Paleressompoulle1 and Fagot &#38; Bonte2 have published an automated learning device (ALDM) for the study of cognitive abilities of monkeys ...

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Den 4 Mountains Test: en kort test af rumlig hukommelse med høj følsomhed for Diagnose af Pre-demens Alzheimers sygdom

This protocol describes the administration of the 4 Mountains Test (4MT), a short test of spatial memory, in which memory for the topographical layout of ...

Using the Race Model Inequality to Quantify Behavioral Multisensory Integration Effects

Brug af race model ulighed for at kvantificere adfærdsmæssige multisensoriske integrations effekter

Multisensory integration research investigates how the brain processes simultaneous sensory information. Research on animals (mainly cats and primates) ...

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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As Parkinson&#8217;s disease (PD) is a heterogeneous disorder, personalized medicine is truly required to optimize care. In their current form, standard ...