Name: automated, long-term behavioral assay for cognitive functions in multiple genetic models of alzheimer's disease, using intellicage
Uploaded: 2018-08-04T15:00:00
Description: Watch this Scientific Journal Video about Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage at JoVE.com

Vi takker Reiko Ando for henne hjelp i fotografering materialer. Denne forskningen ble støttet av Grant-in-Aid for utforskende forskning (Javaserver KAKENHI bevilgning nummer 16K 15196).

Alle prosedyrer ble godkjent av de institusjonelle dyr omsorg og bruk komiteen, og de ble utført etter RIKEN hjernen vitenskap instituttets retningslinjer for dyr eksperimentering.
1. innstillingen apparater
Merk: En oversikt over automatisert hjem-buret overvåkingssystemet er vist i figur 1. Hvert system (39 cm x 58 cm x 21 cm) inneholder en mikroprosessor og fire hjørne chambers, hver har to vannflasker og en ring antenne for å oppd...

<ol>
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T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Habituation+and+sensitization:+new+thoughts+about+old+ideas.">Habituation and sensitization: new thoughts about old ideas.</a> Animal Behaviour. 120, 255-262 (2016).</li><li>Endo, T., Maekawa, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Automated+test+of+behavioral+flexibility+in+mice+using+a+behavioral+sequencing+task+in+IntelliCage.">Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage.</a> Behavioural brain research. 221 (1), 172-181 (2011).</li><li>Voikar, V., Colacicco, G., Gruber, O., Vannoni, E., Lipp, H. -. P., Wolfer, D. 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Dette dokumentet beskriver metoden bruker automatiserte hjem-buret overvåkingssystemet for langsiktig kognitive og atferdsmessige analyser i genmodifiserte AD modeller. Det viktigste trinnet er implantering av transponder riktig plassering. Før du utfører implantation, sikre at utløpsdatoen for transponderen ikke har bestått. Det andre viktige er å sjekke fungerer systemet daglig, spesielt som et mindre problem kan senere bli en mer alvorlig under studien (dvs., et stablet døren, falt ut transponder, dår...

Utvikling av dyr modeller for neuronal sykdom det siste tiåret har gitt en mekanistisk forståelse av deres basis og for å fremme den terapeutiske fremskritt1,2,3. Anvendelsen av en høy gjennomstrømming atferdsmessige testbatteri i genetisk dyremodeller er en heuristisk forskning for å undersøke de underliggende mekanismene menneskelige sykdommer og identifikasjon av stoffet terapi. Forskning test batterier tilrettelagt for langsiktig observasjon av aldring og/eller demens modeller har tradisjonelt tvunget laboratorier å konsumere store mengder spesialiserte arbeidskraft og tid. Et hjem-buret overvåkingssystem ville være en kosteffektiv strategi som det vil redusere kostnadene for atferdsdata observasjon av mennesker. Noen forskergrupper har utviklet automatisert visjon-basert verktøy som hjelper atferdsmessige phenotyping av en enkelt person i et lite hjem bur4,5,6. Men begrense slike metoder sosiale samspillet og størrelsen på testmiljøer rekke atferdsmessige tiltak med kognitive funksjoner. IntelliCage er en andregenerasjons hjem-buret overvåkingssystem som er utformet for å utføre ulike kognitive oppgaver i sosiale hjem bur. Viktigst, denne metoden kan eliminere daglig håndtering som muliggjør oss å utføre langsiktige atferdsmessige overvåking med vurdering av kognitive funksjoner, og det kan eliminere kravene for spesialiserte praktisk håndtering, og aktiverer svært reproduserbare data oppkjøpet7. Her beskriver vi de langsiktige phenotyping og validering i genetisk musen modeller av Alzheimers (AD) som er generert nylig8,9,10 bruker automatiserte hjem-buret overvåking system. Et testbatteri, som inkluderte vurderinger av romlige læring og utøvende funksjoner, ble gjentatte ganger utført med flere alder poeng (9-12 og 14-17 måneder gammel). Denne alder-avhengige phenotyping tillatt oss å identifisere forbigående og/eller permanent effekten av gener på ulike kognitive aspekter. Vi fant at noen AD-modeller viste både midlertidig og permanent fenotyper i flere kognitive aspekter testet i langsiktig analysen ved hjelp av automatiserte hjem-buret overvåking system10. Dermed er automatiserte studien bruker hjem-buret overvåkingssystem fordelaktig og kostnadseffektiv for langsiktig atferdsmessige phenotyping og validering i ulike modeller av kognitiv dysfunksjon.

<table>
	<tbody>
		<tr>
			<td>IntelliCage</td>
			<td>TSE Systems</td>
			<td>-</td>
			<td>Parchased in 2011 or later</td>
		</tr>
		<tr>
			<td>PC</td>
			<td>Dell</td>
			<td>Inspiron 580s</td>
			<td>-</td>
		</tr>
		<tr>
			<td>Display</td>
			<td>Dell</td>
			<td>SI75T-WL</td>
			<td>-</td>
		</tr>
		<tr>
			<td>ALPHA-dri</td>
			<td>Shepherd Specialty Papers</td>
			<td>-</td>
			<td>Standard bedding</td>
		</tr>
		<tr>
			<td>Aron Alpha (Krasy Glue) 2g</td>
			<td>Toagosei (Krasy Glue)</td>
			<td>#04612</td>
			<td>Cyanoacrylates for gluing magnet and blak arm</td>
		</tr>
		<tr>
			<td>Handheld Transponder Reader</td>
			<td>BTS-ID</td>
			<td>R-560</td>
			<td>Transponder reader, which reads both Trovan and DataMars</td>
		</tr>
		<tr>
			<td>Transponder</td>
			<td>DataMars</td>
			<td>T-VA, T-VAS, or another series</td>
			<td>Basic package of transponders and implanters</td>
		</tr>
		<tr>
			<td>Diamond Grip Plus</td>
			<td>Ansel Microflex</td>
			<td>DGP-INT-M</td>
			<td>Experimental glove</td>
		</tr>
		<tr>
			<td>Isoflurane</td>
			<td>Pfizer</td>
			<td>1119701G1092</td>
			<td>-</td>
		</tr>
		<tr>
			<td>Vaporizer for small animals</td>
			<td>DS Pharma Biomedical</td>
			<td>SF-B01</td>
			<td>Facemask included</td>
		</tr>
		<tr>
			<td>Neo-Medrol</td>
			<td>Pfizer</td>
			<td>006472-001</td>
			<td>Eye ointment</td>
		</tr>
		<tr>
			<td>Ethanol (70%)</td>
			<td>-</td>
			<td>-</td>
			<td>-</td>
		</tr>
		<tr>
			<td>Excel</td>
			<td>Microsoft</td>
			<td>00202-51382-15524-AA928</td>
			<td>For data analysis</td>
		</tr>
	</tbody>
</table>

automated, long-term behavioral assay for cognitive functions in multiple genetic models of alzheimer's disease, using intellicage

Flere faktorer — som aldring og gener-er ofte knyttet til kognitiv svikt. Genmodifiserte musen modeller av kognitiv svikt, som Alzheimers sykdom (AD), har blitt en lovende verktøyet å belyse de underliggende mekanismene og fremme de terapeutiske fremskrittene. Et viktig skritt er validering og karakterisering av forventet atferd abnormitet i modellene, i Annonsen, kognitiv svikt. De langsiktige atferdsmessige undersøkelsene av forsøksdyr å studere effekten av aldring etterspørselen betydelig innsats fra forskere. IntelliCage systemet er en høy gjennomstrømming og kostnadseffektiv testbatteri for mus som eliminerer behovet for daglige menneskelig handling. Her beskriver vi hvordan systemet benyttes i den langsiktige phenotyping av en genetisk Alzheimers sykdom modell, spesielt med fokus på kognitive funksjoner. Eksperimentet sysselsetter gjentatte batteri av tester som vurderer romlige læring og utøvende funksjoner. Denne kostnadseffektive alder-avhengige phenotyping tillater oss å identifisere forbigående og/eller permanent effekten av gener på ulike kognitive aspekter.

I vår forrige undersøkelse, ble alder avhengig av kognitiv underskudd i AD modeller oppdaget av eksperimenter ved hjelp av automatiserte hjem-buret overvåking system10. Deres Annonsen modeller i PP var intakt både unge voksne og eldre temaer; men ytelsen i PPR var betydelig og gradvis svekket (figur 6). Det er også viktig å observere hvordan eller angst i tilpasning fase fordi slike egenskaper kan påvirke kognisjon<sup class="xr...

Watch this Scientific Journal Video about Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage at JoVE.com

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Dette dokumentet beskriver en protokoll for kognitive vurderinger for genetisk modeller av Alzheimers bruker IntelliCage systemet, som er en høy gjennomstrømning automatisert atferdsmessige overvåkingssystem med kan opereres forfatning.

Automatisert, langsiktig atferdsdata analyse for kognitive funksjoner i flere genetiske modeller av Alzheimers sykdom, bruker IntelliCage

Multiple factors&#8212;such as aging and genes&#8212;are frequently associated with cognitive decline. Genetically modified mouse models of cognitive ...

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