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En rotte Methyl-Seq plattform å identifisere Epigenetic endringer knyttet til Stress eksponering

DOI :

10.3791/58617-v

9:06 min

October 24th, 2018

October 24th, 2018

10,279 Views

1Departments of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 2Department of Medicine, Johns Hopkins School of Medicine, 3Department of Mental Health, Johns Hopkins School of Public Health

Her beskriver vi protokollen og implementering av Methyl-Seq, en epigenomic plattform, med en rotte modell for å identifisere epigenetic endringer forbundet med kronisk stress eksponering. Resultatene viser at rotte Methyl-Seq plattformen er stand til å oppdage metylering forskjellene som framkommer stress eksponering i rotter.

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