Preparation of Unmodified and Fluorescein Isothiocyanate (FITC)-Modified Lysine-Tyrosine-Phenylalanine (KYF) Tripeptide
5:59
Synthesis of FITC-KYF-Stabilized or KYF-Stabilized Nanoemulsion with Oleic Acid-Pt(II) Cores (FITC-KYF-Pt-NE or KYF-Pt-NE)
8:03
Results: KYF-Pt-NE and FITC-KYF-Pt-NE Characterization
9:43
Conclusion
Transcript
Given the wide range of short peptide sequences, this method can be extended to many other nanoparticle designs. Peptide modification can make the system suitable for diagnostic purposes. Encapsulating anti-cancer platinum to drugs with biodegrada
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This protocol describes an efficient method to synthesize a nanoemulsion of an oleic acids-platinum(II) conjugate stabilized with a lysine-tyrosine-phenylalanine (KYF) tripeptide. The nanoemulsion forms under mild synthetic conditions via self-assembly of the KYF and the conjugate.