Name: calculating heart rate variability from ecg data from youth with cerebral palsy during active video game sessions
Uploaded: 2019-06-05T13:00:00
Description: Watch this Scientific Journal Video about Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions at JoVE.com

作者感谢参与者及其家属为参与研究所花费的时间和精力。同样,作者还感谢刘一川博士和海山·阿亚兹博士协助进行HR监测的时间计算,保罗·迪芬巴赫博士负责开发KOLLECT主动视频游戏软件。这项工作的资金由库尔特基金会赠款#00006143(O' Neil;迪芬巴赫,皮斯)和#00008819(奥尼尔;迪芬巴赫,皮斯)。

机构审查委员会获得批准。所有青年提供书面同意,父母在参与前表示同意。
1. AVG数据收集会议
<ol><li>AVG 游戏会话<ol>
<li>在这项研究中,让CP的青年参加由三个20分钟游戏组成的AVG课程。见青年人口统计表5。预计将总共进行30场比赛;然而,29场比赛已经完成,因为一个主题只打了2场比赛在他的AVG会话。</li>
		<li>让受试者在整个课程期间佩戴 HR 监视器,以记录 HR 和 ECG 响应。</li>
		<li>?...

<ol>
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10名患有CP的青年参加了这项研究(平均= SD)= 年龄(岁) = 15.53 ± 3.57;身高(厘米) 154.8 ± 12.6;体重(公斤) 50.69 ± 11.1;身体质量指数 (BMI) 50.46 ± 29.2;mHR 9 bpm = 186.8 ± 12.4°*有关患者人口统计数据,请参阅表5。
使用 HR 监视器以及 HR 和 HRV 的相关措施需要考虑一些与修改和故障排除相关的措施。无论使用何种技术来获取数据,两个问题显而易见:1) 运动伪影和 2) 异位节拍。运动伪...

脑瘫(CP)是儿童期最常见的身体残疾。CP是由神经性侮辱对发育的大脑造成的,与运动损伤有关,如肌肉无力、痉挛、去功能减退、运动控制和平衡下降2,3。CP 是一种非渐进性疾病,但随着年龄的增长,儿童与具有典型发育 (TD) 的同龄人相比,身体活动较少,久坐不动,这主要是因为他们受损的神经肌肉和肌肉骨骼系统4.
患有CP的青少年通常接受物理治疗(PT)服务,以提高功能流动性,促进身体活动和健身(如有氧和肌肉耐力)2。通常,获得 PT 服务和社区资源的机会有限,以实现和维持这些 PT 目标5、6 。主动视频游戏(AVG)可能是一个可行的策略,在临床,家庭或社区设置7,8基于活动的PT干预。商业APG在适应游戏游戏和满足CP9青少年的特定需求和PT目标的灵活性有限。然而,定制的AvG提供灵活的游戏参数,挑战青少年与CP,同时促进体育活动和健身10。
我们的团队开发了定制的AVG(称为KOLLECT),用于检查青少年运动反应(例如,体育活动和有氧健身)。游戏使用运动传感器来跟踪游戏期间的青年运动。游戏的目标是"收集"尽可能多的对象,以取得高分,并避免危险,避免失去分数。对象可以收集手和/或脚图标由治疗师在灵活的游戏参数确定。
设计基于活动的PT干预,通过身体活动强度促进有氧健身,对于CP11的青少年至关重要。自定义APG可能是一个有效的策略,剂量强度和青年参与体育活动,以促进健身10。心率 (HR) 监测器通常用于临床 PT 实践,以确定有氧运动表现和活动强度。因此,HR监测器将帮助确定AvG在给给体力活动强度方面的可行性,以促进有氧健身9。从 HR 监视器生成的心电图数据可用于计算心率变异性 (HRV)。使用分析方法从心电图数据生成HRV,以检查有氧工作量。HRV最近的应用表明,短期测量(5分钟)是适当的,HRV生物反馈可能有助于改善各种健康状况的症状和生活质量32、33、34.应用短期HRV措施是评估AVG会议期间心血管功能的适当手段。鉴于 HRV 派生自 ECG 的 R-R 间隔,我们使用选定的时域和频域度量。HRV 的时域测量量化了连续心跳之间的连续间隔中的变异性量。我们使用 AVNN(平均 NN 间隔)、RMSSD(连续差的根均平方)、SDNN(NN 间隔的标准偏差)、NN50(NN 间隔数 >50 ms)和 PNN50(NN 间隔的百分比)。频域测量估计绝对功率或相对功率分布为可能四个频段,我们专门针对两个频段,低频(LF)功率和高频(HF)功率以及LF/HF比。虽然HR是一个公认的临床措施,HRV可能是有用的,因为它提供了有关自主系统功能,恢复,适应的信息,并提供AVG会议28期间的有氧工作量的估计。
本研究的目的是研究使用AVG策略促进体育活动和健身的可行性。第二个目的是介绍AVG数据收集协议和通过HR监视器获得的ECG数据计算HRV的方法。这些措施和该协议可能证明与临床医生监测和剂量PT干预会议相关。

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			<td height="21" style="height:21px;width:352px;">BioHarness Bluetooth Module (Electronics sensor)&#160;</td>
			<td style="width:81px;">Zephyr</td>
			<td align="right" style="width:159px;">9800.0189</td>
			<td style="width:475px;">Detects Heart Rate, Resiration Rate, Posture, and Skin Temperature.</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:352px;">BioHarness Chest Strap</td>
			<td style="width:81px;">Zephyr</td>
			<td style="width:159px;">9600.0189, 9600.0190</td>
			<td>Sizes Small XS-M, Large M-XL</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:352px;">BioHarness Charge Cradle &#38; USB Cable</td>
			<td style="width:81px;">Zephyr</td>
			<td align="right" style="width:159px;">9600.0257</td>
			<td>Used to Transfer Data from the Module to a Computer for Analysis.</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:352px;">BioHarness Echo Gateway</td>
			<td style="width:81px;">Zephyr</td>
			<td align="right" style="width:159px;">9600.0254</td>
			<td>Allows for Realtime Viewing of Subject&#39;s Heart Rate.</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:352px;">MATLAB R2016a</td>
			<td style="width:81px;">Mathworks</td>
			<td style="width:159px;">1.7.0_.60</td>
			<td>Used for All Programming.</td>
		</tr>
	</tbody>
</table>

calculating heart rate variability from ecg data from youth with cerebral palsy during active video game sessions

本研究的目的是从心电图(ECG)波形中生成一种计算心率变异性(HRV)的方法。参与者(脑瘫青年(CP))在活动视频游戏(AVG)会话期间佩戴的HR监视器记录了波形。AVG 课程旨在促进参与者的体育活动和健身(有氧表演)。目标是评估AvGs作为物理治疗(PT)干预策略的可行性。为每个参与者确定了最大 HR (mHR),在 20 分钟的 AVG 会话中,针对三个锻炼阶段中的每一个计算目标心率区 (THRZ):(在 40-60% mHR 下预热,在 60-80% mHR 调节,在 40-60% mHR 下冷却)。在AVG会话期间,每个参与者玩了三个20分钟的游戏。所有比赛都是坐在板凳上进行的,因为许多有CP的青年不能长时间站立。每个游戏条件不同,参与者只使用手图标,手和脚图标在一起,或脚图标只收集对象。游戏的目标(称为 KOLLECT)是收集对象来获得积分,并避免不失分的危险。在预热和冷却阶段使用危险,只能促进更慢、可控的运动,以保持目标心率区 (THRZ) 中的 HR。在调理阶段没有危险,以促进更高水平的和更剧烈的体力活动。使用分析方法从ECG数据生成HRV(选定的时域和频域测量),以检查有氧工作负载。HRV最近的应用表明,短期测量(5分钟)是适当的,HRV生物反馈可能有助于改善各种健康状况的症状和生活质量。虽然 HR 是一种公认的临床测量,用于检查 PT 干预中的有氧运动表现和强度,但 HRV 可能在 AVG 会话期间提供自主系统功能、恢复和适应的信息。

该方法提供数据,用于分析新开发的方法对受试者心率可变性 (HRV) 的影响。它通过定位主体心电图数据的QRS波形的R部分(如图6所示)和计算其各种HRV值来达到这一点。如果 HR 监视器与主体进行适当接触,数据将一致,大大减少了更正的需要(如图4所示)。
阈值应设置为处理混乱和不规则?...

Watch this Scientific Journal Video about Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions at JoVE.com

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions

在活动视频游戏会话期间,从脑瘫青年的 ECG 数据计算心率变异性

该协议描述了一种从心电图(ECG)波形计算心率变异性(HRV)的方法。在活动视频游戏 (AVG) 会话期间,连续心率 (HR) 记录产生的波形用于测量脑瘫青年 (CP) 的有氧表现。

The aim of this study was to generate a method for calculating heart rate variability (HRV) from electrocardiogram (ECG) waveforms. The waveforms were ...

协议提供了一种分析方法，用于使用心电图数据测量心率变异性，以确定有氧功能。有了这个，它将帮助我们深入了解物理治疗协议中的自主系统功能。该技术可用于测量脑瘫青年的有氧工作量、需求和物理治疗策略。例如，在物理治疗中，我们正在做技术，以促进健康和健身使用活跃的视频游戏。心率变异性测量有氧工作量，为患者提供心血管功能测量，并允许我们在最恰当地满足和挑战患者的水平上进行物理治疗。该方法在心脏护理和心脏康复中很有用。因此，计算可以集成到心脏监测设备中，以心电图或心电图作为结果提供心率变异性。计算一开始可能具有挑战性。但是，通过创建培训视频，我们可以帮助临床医生和研究人员更好地利用这些措施来评估心脏护理的有效性。对于活跃的视频游戏数据收集会话，选择仅具有手图标、仅双脚图标或手部和脚部图标的主动视频游戏进行对象收集，以确定哪种游戏在促进身体活动和健身方面更有效，而不会过于苛刻，并造成早期过度疲劳。要为脑瘫青少年患者配备心率监测器，请先将充满电的蓝牙模块插入数据计算机，将其作为充电摇篮，然后打开配置工具。使用湿手润湿心率监测胸带上的导电区域。将蓝牙模块放入胸带中，模块的导电表面与胸带的导电表面排列。监视器将单击到位。然后将心率监测胸带和蓝牙模块应用到主体中，模块与左中轴线和胸肌下的表带对齐。正确定位后，拧紧设备，使设备在会话期间不会移动，但对主体不会感到不舒服。让主体坐在长凳上，双脚平放在地板上，膝盖和臀部弯曲到 90 度，以进行姿势支撑和稳定性。将连接器插入计算机的 USB 端口，用于查看数据，并使用实时模式选项卡实时监控主体的心率、呼吸速率和姿势。然后记录主体休息一段时间，以获得主题的心率基线记录，然后再开始主题的第一个活动视频游戏。游戏会话结束时，从心率监测器下载心电图数据，然后从主体上取下表带。要计算心电图数据的心率变异性，请打开 MATLAB，将数据组织成五分钟的间隔，以确保各阶段之间的可比数据。将休息时间计算为游戏开始前的五分钟和恢复阶段，将冷却阶段结束后的五分钟计算，以对原始心电图信号执行 R 峰值检测。获得这些时间后，确定 ECG 文件中感兴趣的游戏阶段的位置，并选择感兴趣的五分钟部分。基于波形的平均值和标准偏差计算峰值检测阈值。与 R 峰值的最小高度一起，在峰值之间分配 0.3 秒的最小距离，以最大限度地减少在所需 R 周围检测到不正确的峰值。m 处理波形，并尝试识别节拍间间隔和心率变异性计算的所有 R 峰值。生成初步绘图，以便可以检查异常情况，如图所示。许多数据会话相当统一，因此只需要一些更正。然而，有些情况相当混乱，需要更多的时间来审查和获得适当的 R 位置。要纠正这些不规则现象，请手动编辑包含第一列中峰值微伏读数的检测变量以及第 2 列中当前游戏会话中的位置。在大多数情况下，可以通过放大问题位置轻松找到正确的 R 峰值。获取间隔矩阵，忽略任何大于 1.5 秒的间隔，并保存这些节拍间隔，以便进一步计算数据验证。然后使用这些间隔计算连续差的根均值正方形。在计算心率变异性测量之前，打开波形以检查正确的峰值检测。使用放大工具选择在窗口不易于直观地检查时输出放大或缩小的绘图区域。使用数据提示工具查找错过的峰值的位置。对于峰值校正，在工作区中定位检测变量并双击以更正错误检测到或缺少的峰值。如果该点为误报，请从数组中删除该点，并更改与未标记峰值相邻的任何未标记峰值的值与未标记峰值的值。然后获得心率变异性测量计算，运行 hrv 测量。m，然后从工作区窗口打开心率变异变量。该方法通过在主体的ECG数据中定位QRS波形的R部分，提供数据，用于分析新开发的主动视频游戏方法对特定主体心率变异性的影响。如果心率监测器与主体进行适当接触，数据将统一，从而大大减少了矫正需求。如果由于心率监测器皮肤接触的瞬间变化，数据具有足够的变化，则初始分析可能会错误地将峰值标记为指示。在峰值之间的最短时间内更改阈值级别还有助于清理生产和调整后的图的检测值。在计算心率变异数据之前，必须平移每个波形，以确保正确的峰值检测、删除误报和移动标记错误的峰值。使用心率变异性测量的其他考虑因素和影响包括生理考虑、水化状态和环境影响。这种方法在基于活动的物理治疗干预中很有用，因为在过去十年中，人们从基于残疾的干预措施到更多的健康促进和健身，这种方法使我们能够测量健身和功能流动性。在应用心率监测器之前，您需要确保皮肤不被刺激，并且设备正在良好修复中，以避免皮肤擦伤。

Research

JoVE Journal

Behavior

Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation

微分热感集中注意建议期间同步 fMRI/EEG 数据收集方法

In the present work, we demonstrate a method for concurrent collection of EEG/fMRI data. In our setup, EEG data are collected using a high-density ...

科研

行为学

Best Current Practice for Obtaining High Quality EEG Data During Simultaneous fMRI

获得高质量的脑电数据在同步功能磁共振成像的当前最佳实践

Simultaneous  EEG-fMRI allows the excellent temporal resolution of EEG to be combined with the  high spatial accuracy of fMRI. The data  from these two ...

Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats

考试多巴胺快速与动态快速扫描循环伏安法在口内呈味物质管理清醒大鼠

Rapid, phasic dopamine (DA) release in the mammalian brain plays a critical role in reward processing, reinforcement learning, and motivational control. ...

Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

事件相关电位在目标响应的任务，研究的上肢使用在儿童认知过程单侧脑性麻痹

Unilateral Cerebral Palsy (CP) is a neurodevelopmental disorder that is a very common cause of disability in childhood. It is characterized by unilateral ...

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

可逆冷却诱导 Deactivations 对行走猫的障碍记忆的皮层贡献研究

On complex, naturalistic terrain, sensory information about an environmental obstacle can be used to rapidly adjust locomotor movements for avoidance. For ...

Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation

基于移动游戏的上肢卒中康复虚拟现实程序

Stroke rehabilitation requires repetitive, intensive, goal-oriented therapy. Virtual reality (VR) has the potential to satisfy these requirements. ...

The (Spatial) Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

The Spatial Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition

The memory game paradigm is a behavioral procedure to explore the relationship between language, spatial memory, and object knowledge. Using two different ...

Measuring Active and Passive Tameness Separately in Mice

小鼠主动和被动驯服的测定

Domesticated animals such as dogs and laboratory mice show a high level of tameness, which is important for humans to handle them easily. Tameness has two ...

Modified Blood Collection from Tail Veins of Non-anesthetized Mice with a Vacuum Blood Collection System and Eyeglass Magnifier

真空采血系统和眼镜放大镜从非麻醉小鼠尾静脉中修饰采血

Blood sample collection is the basis of experimental animal research. It is of importance to obtain adequate blood samples for various research purposes. ...

Applying Incongruent Visual-Tactile Stimuli during Object Transfer with Vibro-Tactile Feedback

在振动触觉反馈的对象传递过程中应用不一致的视觉触觉刺激

The application of incongruent sensory signals that involves disrupted tactile feedback is rarely explored, specifically with the presence of vibrotactile ...