Implantation af en Isoproterenol-mini pumpe for at inducere hjertesvigt i mus
October 3rd, 2019
•1Department of Anesthesiology, University of California, 2Department of Medicine, University of California, 3Department of Microbiology, Immunology & Molecular Genetics, University of California, 4Department of Molecular, Cell, and Developmental Biology, University of California
Den kroniske administration af izoproterenol via en implanteret osmotisk pumpe er blevet brugt bredt til at efterligne fremskreden hjerteinsufficiens i mus. Her beskriver vi detaljerede metoder i kirurgisk mini-pumpe implantation til kontinuerlig izoproterenol administration over 3 uger, samt ekkokardiografisk vurdering for den vellykkede model skabelse.
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