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DOI :
10.3791/59690-v
July 11th, 2019
Chapters
0:04
Title
1:31
Isolation of PBMNCs (Peripheral Blood Mononuclear Cells)
3:00
Expansion of MNCs
4:12
Reprogramming of PBMNCs to iNSCs (Induced Neural Stem Cells) by SeV (Sendai Virus) Infection
7:20
Establishment of Unilateral 6-Hyroxydopamine (6-OHDA)-Lesioned Parkinson s Disease (PD) Mouse Models
9:15
Results: Induced Neural Stem Cells Differentiation Toward Dopaminergic Neuron Precursors and Treatment of Parkinson s Disease Mouse Models
11:00
Conclusion
このプロトコルは、仙台ウイルス感染による神経幹細胞を誘導する末梢血単核細胞のリプログラミング、ドーパミン作動性ニューロンへのiNSCの分化、DA前駆体の一方的な病変への移植を提示するパーキンソン病マウスモデル、およびPD治療のためのiNSC由来DA前駆体の安全性および有効性の評価。
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