Name: integration of brain tissue saturation monitoring in cardiopulmonary exercise testing in patients with heart failure
Uploaded: 2019-10-01T15:00:00
Description: Watch this Scientific Journal Video about Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure at JoVE.com

参加运动测试的病人深受赞赏。这项研究得到了台湾国家科学委员会（NMRPG3G6231/2/3）、长荣纪念医院（授权号）的支持。CMRPG3G0601/2），以及长荣大学健康老龄化研究中心和台湾教育部高等教育深度犁计划（助学金编号EMRPD1H0351和EMRPD1H0551）。

以下协议由台湾林口长贡纪念医院伦理委员会批准。演习试验在大气温度为22-25°C、气压为755至770托、相对湿度为55-65%的空调实验室进行。在每次测试之前，气体分析仪都按照制造商的指示进行校准，使用室内空气和已知浓度的气体混合物（FO2： 0.12;FCO2： 0.05;N2作为平衡）。系统涡轮流量计采用自动泵送系统，采用0.2升/s和2升/s的2点法进行校准。
1. 准?...

<ol>
	<li>Balady, G. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinician's+Guide+to+cardiopulmonary+exercise+testing+in+adults:+a+scientific+statement+from+the+American+Heart+Association.">Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association.</a> Circulation. 122 (2), 191-225 (2010).</li><li>Corra, U., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiopulmonary+exercise+testing+in+systolic+heart+failure+in+2014:+the+evolving+prognostic+role:+a+position+paper+from+the+committee+on+exercise+physiology+and+training+of+the+heart+failure+association+of+the+ESC.">Cardiopulmonary exercise testing in systolic heart failure in 2014: the evolving prognostic role: a position paper from the committee on exercise physiology and training of the heart failure association of the ESC.</a> European Journal of Heart Failure. 16 (9), 929-941 (2014).</li><li>Malhotra, R., Bakken, K., D'Elia, E., Lewis, G. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiopulmonary+Exercise+Testing+in+Heart+Failure.">Cardiopulmonary Exercise Testing in Heart Failure.</a> JACC Heart Fail. 4 (8), 607-616 (2016).</li><li>Chen, Y. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cerebral+desaturation+in+heart+failure:+Potential+prognostic+value+and+physiologic+basis.">Cerebral desaturation in heart failure: Potential prognostic value and physiologic basis.</a> PloS One. 13 (4), e0196299 (2018).</li><li>Koike, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinical+significance+of+cerebral+oxygenation+during+exercise+in+patients+with+coronary+artery+disease.">Clinical significance of cerebral oxygenation during exercise in patients with coronary artery disease.</a> Circulation Journal. 72 (11), 1852-1858 (2008).</li><li>Madsen, P. L., Secher, N. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Near-infrared+oximetry+of+the+brain.">Near-infrared oximetry of the brain.</a> Progress in Neurobiology. 58 (6), 541-560 (1999).</li><li>Wahr, J. A., Tremper, K. K., Samra, S., Delpy, D. T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Near-infrared+spectroscopy:+theory+and+applications.">Near-infrared spectroscopy: theory and applications.</a> Journal of Cardiothoracic and Vascular Anesthesia. 10 (3), 406-418 (1996).</li><li>Fischer, G. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Recent+advances+in+application+of+cerebral+oximetry+in+adult+cardiovascular+surgery.">Recent advances in application of cerebral oximetry in adult cardiovascular surgery.</a> Seminars in Cardiothoracic and Vascular Anesthesia. 12 (1), 60-69 (2008).</li><li>Benni, P. B., MacLeod, D., Ikeda, K., Lin, H. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+validation+method+for+near-infrared+spectroscopy+based+tissue+oximeters+for+cerebral+and+somatic+tissue+oxygen+saturation+measurements.">A validation method for near-infrared spectroscopy based tissue oximeters for cerebral and somatic tissue oxygen saturation measurements.</a> Journal of Clinical Monitoring and Computing. 32 (2), 269-284 (2018).</li><li>Strangman, G., Boas, D. A., Sutton, J. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Non-invasive+neuroimaging+using+near-infrared+light.">Non-invasive neuroimaging using near-infrared light.</a> Biological Psychiatry. 52 (7), 679-693 (2002).</li><li>Ide, K., Secher, N. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cerebral+blood+flow+and+metabolism+during+exercise.">Cerebral blood flow and metabolism during exercise.</a> Progress in Neurobiology. 61 (4), 397-414 (2000).</li><li>Immink, R. V., Secher, N. H., van Lieshout, J. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cerebral+autoregulation+and+CO2+responsiveness+of+the+brain.">Cerebral autoregulation and CO2 responsiveness of the brain.</a> American Journal of Physiology: Heart and Circulatory Physiology. 291 (4), H2018 (2006).</li><li>Chan, M. J., Chung, T., Glassford, N. J., Bellomo, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Near-Infrared+Spectroscopy+in+Adult+Cardiac+Surgery+Patients:+A+Systematic+Review+and+Meta-Analysis.">Near-Infrared Spectroscopy in Adult Cardiac Surgery Patients: A Systematic Review and Meta-Analysis.</a> Journal of Cardiothoracic and Vascular Anesthesia. 31 (4), 1155-1165 (2017).</li><li>Sakudo, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Near-infrared+spectroscopy+for+medical+applications:+Current+status+and+future+perspectives.">Near-infrared spectroscopy for medical applications: Current status and future perspectives.</a> Clinica Chimica Acta. 455, 181-188 (2016).</li><li>Crimi, E., Ignarro, L. J., Cacciatore, F., Napoli, C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mechanisms+by+which+exercise+training+benefits+patients+with+heart+failure.">Mechanisms by which exercise training benefits patients with heart failure.</a> Nature Reviews: Cardiology. 6 (4), 292-300 (2009).</li><li>Pina, I. L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Exercise+and+heart+failure:+A+statement+from+the+American+Heart+Association+Committee+on+exercise,+rehabilitation,+and+prevention.">Exercise and heart failure: A statement from the American Heart Association Committee on exercise, rehabilitation, and prevention.</a> Circulation. 107 (8), 1210-1225 (2003).</li><li>Franciosa, J. A., Park, M., Levine, T. B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Lack+of+correlation+between+exercise+capacity+and+indexes+of+resting+left+ventricular+performance+in+heart+failure.">Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure.</a> American Journal of Cardiology. 47 (1), 33-39 (1981).</li><li>Koike, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cerebral+oxygenation+during+exercise+and+exercise+recovery+in+patients+with+idiopathic+dilated+cardiomyopathy.">Cerebral oxygenation during exercise and exercise recovery in patients with idiopathic dilated cardiomyopathy.</a> American Journal of Cardiology. 94 (6), 821-824 (2004).</li><li>Koike, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cerebral+oxygenation+during+exercise+in+cardiac+patients.">Cerebral oxygenation during exercise in cardiac patients.</a> Chest. 125 (1), 182-190 (2004).</li><li>Amann, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Arterial+oxygenation+influences+central+motor+output+and+exercise+performance+via+effects+on+peripheral+locomotor+muscle+fatigue+in+humans.">Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans.</a> Journal of Physiology. 575 (Pt 3), 937-952 (2006).</li><li>Fu, T. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Suppression+of+cerebral+hemodynamics+is+associated+with+reduced+functional+capacity+in+patients+with+heart+failure.">Suppression of cerebral hemodynamics is associated with reduced functional capacity in patients with heart failure.</a> American Journal of Physiology: Heart and Circulatory Physiology. 300 (4), H1545-H1555 (2011).</li><li>Myers, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+lowest+VE/VCO2+ratio+during+exercise+as+a+predictor+of+outcomes+in+patients+with+heart+failure.">The lowest VE/VCO2 ratio during exercise as a predictor of outcomes in patients with heart failure.</a> Journal of Cardiac Failure. 15 (9), 756-762 (2009).</li><li>Wasserman, A. J., Patterson, J. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+cerebral+vascular+response+to+reduction+in+arterial+carbon+dioxide+tension.">The cerebral vascular response to reduction in arterial carbon dioxide tension.</a> Journal of Clinical Investigation. 40, 1297-1303 (1961).</li><li>Ross, A., Marco, G., Jonathan, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ventilatory+Abnormalities+During+Exercise+in+Heart+Failure:+A+Mini+Review.">Ventilatory Abnormalities During Exercise in Heart Failure: A Mini Review.</a> Current Respiratory Medicine Reviews. 3 (3), 179-187 (2007).</li><li>Herholz, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Regional+cerebral+blood+flow+in+man+at+rest+and+during+exercise.">Regional cerebral blood flow in man at rest and during exercise.</a> Journal of Neurology. 234 (1), 9-13 (1987).</li><li>Karlman Wasserman, J. E. H., Sue, D. Y., Stringer, W. W., Whipp, B. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications. , 285-299 (2011).</li><li>Pott, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Middle+cerebral+artery+blood+velocity+during+rowing.">Middle cerebral artery blood velocity during rowing.</a> Acta Physiologica Scandinavica. 160 (3), 251-255 (1997).</li><li>Yoshitani, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Measurements+of+optical+pathlength+using+phase-resolved+spectroscopy+in+patients+undergoing+cardiopulmonary+bypass.">Measurements of optical pathlength using phase-resolved spectroscopy in patients undergoing cardiopulmonary bypass.</a> Anesthesia and Analgesia. 104 (2), 341-346 (2007).</li><li>MacLeod, D. I., Ikeda, K., Cheng, C., Shaw, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Validation+of+the+Next+Generation+FORE-SIGHT+Elite+Tissue+Oximeter+for+Adult+Cerebral+Tissue+Oxygen+Saturation.">Validation of the Next Generation FORE-SIGHT Elite Tissue Oximeter for Adult Cerebral Tissue Oxygen Saturation.</a> Anesthesia and Analgesia. 116 (SCA Suppl), (2013).</li><li>Davie, S. N., Grocott, H. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Impact+of+extracranial+contamination+on+regional+cerebral+oxygen+saturation:+a+comparison+of+three+cerebral+oximetry+technologies.">Impact of extracranial contamination on regional cerebral oxygen saturation: a comparison of three cerebral oximetry technologies.</a> Anesthesiology. 116 (4), 834-840 (2012).</li><li>Ogoh, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+decrease+in+spatially+resolved+near-infrared+spectroscopy-determined+frontal+lobe+tissue+oxygenation+by+phenylephrine+reflects+reduced+skin+blood+flow.">A decrease in spatially resolved near-infrared spectroscopy-determined frontal lobe tissue oxygenation by phenylephrine reflects reduced skin blood flow.</a> Anesthesia and Analgesia. 118 (4), 823-829 (2014).</li></ol>

NIRS对无创和连续监测的脑氧合已应用于各种场景，包括心血管手术13和大脑功能分析，如那些估计神经活动14。该协议将NIRS集成到传统的CPET中，以确定HF患者在运动不耐受中脑血液动力学反应的参与度。它增加了运动测试在确定预后和疾病严重程度时的价值。
心脏功能障碍被认为是HF15患者运动不耐受的主要原因。尽管如?...

心肺运动测试（CPET）已应用于心力衰竭患者与减少喷射分数（HF）为多个目标，包括定量心肺健身，预后，诊断运动限制的原因，和运动处方1，2，3。在测试过程中，对来自自动气体交换的流体动力学变量和数据进行监测和分析。脑组织氧饱和度（SctO2）监测具有分级预后和疾病严重程度4，5。
近红外光谱（NIRS）使用红外光穿透头骨，并估计脑组织氧合持续和非侵入性6。由于氧血红蛋白和脱氧血红蛋白具有不同的光吸收光谱，是吸收光的主要色母，因此其浓度可以用透光和吸收6、7进行测量。然而，背景光吸收器也会散射光，并可能影响测量8。这项研究采用了空间解析的NIRS来测量从休息到高峰运动9的SctO2。发射四个波长，以补偿波长依赖散射损耗，消除背景干扰，从而提高精度10。
SctO2表示脑组织中氧气输送与消耗的比例。脑脱饱和与脑血流紊乱（CBF）、动脉氧浓度降低、脑组织耗氧量增加有关11。除了心脏输出不足外，高级HF在运动过程中通过减少二氧化碳（PaCO2）的动脉部分压力，通过过度通气间接诱导脑血管收缩，导致脑下灌注12.
陈等人揭示了HF脑氧合的临床意义。首先，与健康对照组相比，HF组中的SctO2显著减少。SctO2不仅在休息时减少，而且在锻炼期间进一步下降。在健康组中未观察到它。其次，SctO2rest和SctO2峰与VO2峰、脑酸尿肽（BNP）和氧吸氧效率斜率（OUES）相关，所有这些都是既定的预后标记。因此，SctO2rest和SctO2peak很可能预后，并反映HF患者的疾病严重程度。Koike等人的另一项研究表明，与冠状动脉疾病患者的幸存者相比，非幸存者额头上从休息到高峰运动时测得的脑氧血红蛋白变化明显较低。因此，可以使用脑氧合来分层HF患者的疾病严重程度和预后。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Bicycle ergometer</td>
			<td>Ergoline, Germany</td>
			<td>Ergoselect 150P</td>
			<td></td>
		</tr>
		<tr>
			<td>Cardiopulmonary exercise testing gas analysis</td>
			<td>Cardinal-health Germany</td>
			<td>MasterScreen CPX</td>
			<td></td>
		</tr>
		<tr>
			<td>Finger pulse oximetry</td>
			<td>Nonin Onyx, Plymouth, Minnesota</td>
			<td>Model 9500</td>
			<td></td>
		</tr>
		<tr>
			<td>Sphygmomanometer</td>
			<td>SunTech Medical, UK</td>
			<td>Tango</td>
			<td></td>
		</tr>
	</tbody>
</table>

integration of brain tissue saturation monitoring in cardiopulmonary exercise testing in patients with heart failure

休息或运动期间的脑缺氧对心力衰竭患者的运动能力产生负面影响，而喷射分数（HF）减少。然而，在临床心肺运动测试（CPET）中，脑血管动力学不评估。NIRS用于测量前额叶的脑组织氧饱和度（SctO2）。该方法可靠有效，已多次用于研究。在HF患者的休息和高峰运动期间，SctO2低于健康对照组（66.3 ± 13.3% 和 63.4 ± 13.8%，而 73.1 = 2.8%和 72 = 3.2%）。Rest 的 SctO2与峰值 VO2（r = 0.602）、吸氧效率斜率（r = 0.501）和脑神经肽肽（r = -0.492） 呈显著线性相关，所有这些都是公认的预后和疾病严重性标记，指示其潜在的预后值。SctO2主要由HF种群的末潮CO2压力、平均动脉压力和血红蛋白决定。本文演示了一种协议，该协议使用 NIRS 将 SctO2集成到校准自行车测速仪上的增量 CPET 中。

台湾林口长公纪念医院收治了34名HF患者和17名健康对照医生。每个受试者都接受了心肺运动测试，其中纳入了NIRS的SctO2监测。简单地说，HF组（66.3 ± 13.3%;63.4 ± 13.8%）的SctO2（休息;峰值）值明显低于对照组（73.1 ± 2.8%;72 = 3.2%）组 （图 1）。在HF组中，静止的SctO 2（SctO2rest）和峰值SctO2（SctO 2峰值）与脑神经肽?...

Watch this Scientific Journal Video about Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure at JoVE.com

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

该协议将近红外光谱纳入传统的心肺锻炼测试，以确定心力衰竭患者在运动不耐受性中参与脑血液动力学反应的参与度。

心力衰竭患者心肺运动测试中脑组织饱和监测的集成

Cerebral hypo-oxygenation during rest or exercise negatively impacts the exercise capacity of patients with heart failure with reduced ejection fraction ...

心力衰竭中脑组织饱和的程度已证明能反映功能能力和疾病严重性，具有潜在的预后价值。运动测试期间的雷达监测具有临床价值。NIRS测量的脑组织氧饱和度简单方便。该协议将NIRS整合到常规CPET中，以增加心力衰竭患者运动测试的价值。演示该程序将是刘宇陈，一个技术人员从我们实验室。要开始此过程，请用酒精垫清洁患者的额头两次，以清除皮肤上的汗水和污垢。获取大型 NIRS 传感器，其中发射器和探测器之间的距离为 5 厘米，并双边将传感器放在前额上。确保传感器牢固连接。接下来，将 EKG 电极应用于前胸部、双边关节和下背部。让患者坐在自行车测速仪上，将测速仪的臂章放在他们上。然后，佩戴患者气体分析面罩，将脉搏血小米的传感器放在患者的食指上。首先，告诉患者至少休息两分钟，以获得稳定的基线值，包括脑组织氧饱和度和呼吸交换率。接下来，让患者以 10 瓦的工作速率完成循环测速仪上的预热阶段，一分钟。将速率提高 10 瓦/分钟，然后要求患者以大约 60 rpm 的转速踩踏，直到尽管受到强烈鼓励，仍无法跟上超过 50 rpm 的节奏。从以100赫兹频率扫描的数据中自动平均每一秒的脑组织氧饱和度值。分析气体成分，呼吸，包括吸氧和末潮二氧化碳压力。然后，让患者以零瓦的工作速率完成恢复阶段，持续两到六分钟。在这项研究中，心力衰竭患者和健康对子都进行了心肺运动测试，其中纳入了NIRS的脑组织氧饱和度监测。在心力衰竭组中，脑组织氧饱和度值明显低于对照组。在心力衰竭组，脑组织在休息和峰值时氧饱和度与脑骨化肽、峰值吸氧量和吸氧效率斜率呈线性相关。值得注意的是，脑组织在休息时氧饱和度由休息时末潮二氧化碳、血红蛋白和休息时平均动脉压力的部分压力决定。程序简单方便。低脑饱和度指数患者需要高度医疗照顾。NIRS集成到CPET有助于描述脑血流抑制的参与，导致心脏衰竭患者的运动不耐受。除了其预后值外，还需要纵向研究来确认。

Research

JoVE Journal

Medicine

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

缺血性心力衰竭在临床前模型的转基因

Various emerging technologies are being developed for patients with heart failure. Well-established preclinical evaluations are necessary to determine ...

科研

医学

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

驾驶模拟诊所：测试视觉与视野缺损的患者在日常活动中的探索行为

Patients suffering from homonymous hemianopia after infarction of the posterior cerebral artery (PCA) report different degrees of constraint in daily ...

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized dynamic posturography with the EquiTest is an objective technique for measuring postural strategies under challenging static and dynamic ...

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

心动过速诱发的心肌病作为猪慢性心力衰竭模型的研究

A stable and reliable model of chronic heart failure is required for many experiments to understand hemodynamics or to test effects of new treatment ...

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

植入异丙酮醇微型泵，以诱导小鼠心力衰竭

Isoproterenol (ISO), is a non-selective beta-adrenergic agonist, that is used widely to induce cardiac injury in mice. While the acute model mimics ...

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

使用漫反射光谱实时监测神经危重症患者

Neurophysiological monitoring is an important goal in the treatment of neurocritical patients, as it may prevent secondary damage and directly impact ...

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

藏族小型猪射血分数保留的心力衰竭手术模型

More than half of heart failure (HF) cases are classified as heart failure with preserved ejection fraction (HFpEF) worldwide. Large animal models are ...

Predicting Prognosis in Acute Heart Failure Using Phase Angle & BIVA Z-Scores

Clinical Application of Phase Angle and BIVA Z-Score Analyses in Patients Admitted to an Emergency Department with Acute Heart Failure

Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis (Video) | JoVE

相位角和BIVA Z评分分析在急诊科急性心力衰竭患者中的临床应用

Acute heart failure is characterized by neurohormonal activation, which leads to sodium and water retention and causes alterations in body composition, ...

Developing an Exercise Program for Rheumatoid Arthritis Patients

Evaluation of Changes in Hydration and Body Cell Mass with Bioelectrical Impedance Analysis after Exercise Program for Rheumatoid Arthritis Patients

Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass (Video) | JoVE

类风湿性关节炎患者运动计划后通过生物电阻抗分析评估水合作用和体细胞质量的变化

Rheumatoid arthritis (RA) is a debilitating disease that can result in complications such as rheumatoid cachexia. While physical exercise has shown ...

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Ischemic heart disease (IHD) represents a group of clinical syndromes characterized by myocardial ischemia, leading to an impairment in the myocardial ...