Sammenligne metastatisk klar celle nyrecelle karsinom modell etablert i mus nyre og på kylling chorioallantoic membran
February 8th, 2020
•Moe Ishihara1*, Junhui Hu1*, Xiaoyu Zhang2, YongHyeon Choi3, Anthony Wong4, Celine Cano-Ruiz5, Rongwei Zhao6, Ping Tan7, Jonathan L. Tso1, Lily Wu1,8
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 2Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 3Department of Bioengineering, Hanyang University, 4Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 5Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 6School of Life Sciences, Beijing Normal University, 7Department of Urology, West China Hospital, Sichuan University, 8Department of Urology, David Geffen School of Medicine, University of California, Los Angeles
Metastatisk klart celle nyrecellekarsinom er en sykdom uten en omfattende dyremodell for grundig preklinisk undersøkelse. Denne protokollen illustrerer to nye dyremodeller for sykdommen: den ortotopisk implanterte musemodellen og kyllingkorioallantoisk membranmodell, som begge viser lungemetastase som ligner kliniske tilfeller.
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