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DOI :
10.3791/60351-v
•
9:15 min
January 12th, 2020
Chapters
0:04
Title
0:42
Experimental Setup and Purified Experimental Diet Acclimatization
1:21
Vinyl Chloride (VC) Inhalation Exposure System Setup
2:17
Pre-Exposure Setup
3:21
Exposure Experiment and VC Concentration Validation
6:12
Post-Exposure
7:01
Results: Representative Effects of VC on the Enhancement of Diet-Induced Liver Injury
8:29
Conclusion
このプロトコルの目標は、過度の肝臓損傷を引き起こさないが、むしろ既存の肝臓の損傷を悪化させる低レベルの毒性暴露のマウスモデルを開発することであった。このパラダイムは、人間の暴露と安全と考えられる毒性濃度への暴露時に起こる微妙な変化をよりよく再現します。
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