Name: measuring the motor aspect of cancer-related fatigue using a handheld dynamometer
Uploaded: 2020-02-20T14:00:00
Description: Watch this Scientific Journal Video about Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer at JoVE.com

这项研究得到了马里兰州贝塞达国家卫生研究院国家护理研究所内学研究部的充分支持。

目前的研究（NCT00852111）得到了国家卫生研究院机构审查委员会（IRB）的批准。参加这项研究的受试者年龄在18岁或以上，被诊断患有非转移性前列腺癌，有或没有事先进行前列腺切除术，并计划在NIH临床放射肿瘤诊所接受外束放射治疗中心。如果潜在参与者患有可能导致严重疲劳的渐进性疾病、过去五年内患有精神疾病、未纠正甲状腺功能减退或贫血，或患有第二次恶性肿瘤，则被排除在外。使...

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R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Quantitative+assessment+of+motor+fatigue+and+strength+in+MS.">Quantitative assessment of motor fatigue and strength in MS.</a> Neurology. 53, 743-743 (1999).</li><li>Hunter, S. K., Critchlow, A., Shin, I. S., Enoka, R. 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在这里，我们提供三种不同的方法来测量CRF的物理尺寸。使用手持测功机进行电机疲劳测试简单且易于适应临床使用。由于文献中存在许多测试变体，我们的目标是提供标准化方法来管理这些测试，并减少对临床医生进行广泛的面对面培训的需求。
虽然本研究中概述的疲劳测试证明测试可靠性良好，但遵守该协议将确保数据可重复...

癌症相关疲劳（CRF）是一种普遍和衰弱的症状，报告多达80%的癌症患者1。国家综合癌症网络（NCCN）将CRF定义为一种持续的身体、情感和认知疲惫感。通用报告制的主要区别在于与近期活动不成比例，以及通用报告一无法通过休息1来缓解。因此，CRF严重影响了患者参与日常活动及其与健康有关的生活质量1。
目前对通用报告单的评估主要依靠自我报告问卷2。因此，使用自我报告测量的症状严重性受到召回和报告偏差的影响，并可能受用于评估 CRF3的特定调查问卷和截止分数的影响。作为一个多维结构，CRF的物理维度已被证明与日常活动变化和白天午睡的需求相关，而CRF对身体机能的影响则较少。迄今为止，CRF仍然是一个诊断不足和治疗不足的症状，没有明确界定的基础机制或治疗选项1。为了更好地了解这种使人衰弱的状况，越来越需要客观和定量地衡量通用报告标准（CRF）及其尺寸。
身体疲劳是指在持续的收缩活动5期间无法维持所需的力量。随后由于无法执行日常任务（例如，携带购物袋、提和搬运物品）而影响日常功能，这严重影响了与健康有关的生活质量，特别是在老年人中，并造成未来6、7日的伤害。已经开发了各种工具来量化身体损伤，包括身体性能测试，如6分钟步行测试（6MWT）和坐到台测试（STS），以及可穿戴的体力活动监测器，如运动仪和健身跟踪器8，9，10。物理性能测试，如6MWT和STS易于管理，不需要特殊设备10。然而，这种测试的可靠性和成功要求临床医生培训和后勤要求，如30米的走廊10。可穿戴活动监测器允许自动数据收集和纵向症状监测11。然而，这些活动监测器通常需要佩戴多天，患者依从性可能是一个问题11。此外，使用活动监测器收集的大量数据可能很难处理，因此很难获得具有临床意义的信息11。
手持式测功机，或用于计算机辅助数据采集的仪器手柄装置，是一种测量握力的便携式设备。手持式测能已用于测试运动疲劳和损伤的疾病条件，通常涉及运动系统，包括运动神经元和肌肉问题12。最近的工作已经证明，自报的主观CRF分数与使用手柄静态疲劳测试13测量的运动疲劳之间存在关联。手柄疲劳测试特别适合临床使用，因为它们的可靠性和时间效率，需要几分钟才能完成14，15。此外，手柄疲劳测试可以预先编程，确保数据可重复性 7。管理手柄测试需要测试管理员的最少培训，并且在给定标准化协议的情况下，可以在临床环境中轻松实现。将自报疲劳问卷与手柄疲劳测试结合使用，应可为临床医生提供额外的工具，用于筛查、监测和管理癌症患者的疲劳症状。
缺乏标准化的共识方法限制了16号诊所采用手柄疲劳测试。在目前的工作中，我们概述了使用手持测功机客观地量化电机疲劳的三种不同的方法。应在每个癌症人群中测试每种方法的效用，以确保其准确区分疲劳和非疲劳的受试者。我们还概述了计算每个手柄疲劳测试的疲劳指数的方法。这项工作的目的是提供一个全面的工具包，以补充自报问卷，并准确和客观地标准化通用报告F的物理绩效测量。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Quantitative Muscle Assessment application (QMA)</td>
			<td>Aeverl Medical</td>
			<td>QMA 4.6</td>
			<td>Data acquisition software. NOTE: other brands/models can be used as long as the software records force over time.</td>
		</tr>
		<tr>
			<td>QMA distribution box</td>
			<td>Aeverl Medical</td>
			<td>DSTBX</td>
			<td>Software distribution box which connects the handgrip to the software.</td>
		</tr>
		<tr>
			<td>Baseline hand dynamometer with analog output</td>
			<td>Aeverl Medical</td>
			<td>BHG</td>
			<td>Instrumented handgrip device with computer assisted data acquisition. NOTE: other brands/models can be used as long as the instrument measures force over time</td>
		</tr>
	</tbody>
</table>

measuring the motor aspect of cancer-related fatigue using a handheld dynamometer

癌症相关疲劳 （CRF） 通常报告患者在接受癌症治疗期间和之后。目前的通用报告报告单依赖于自我报告问卷，这些问卷存在报告和召回偏差。使用手持测功机（或手握装置）的客观测量在最近的研究中显示，这与主观自我报告的疲劳评分有显著关联。然而，在文献中存在着手柄疲劳试验和疲劳指数计算的变化。缺乏标准化的方法限制了在临床和研究环境中使用手柄疲劳测试。本研究提供了物理疲劳试验和疲劳指数计算的详细方法。这些方法应补充现有的自我报告的疲劳问卷，并帮助临床医生客观和定量地评估疲劳症状的严重程度。

代表力（kg）与时间（s）的跟踪如图1所示。在静态疲劳测试期间，受试者通常在2~3秒23内达到最大强度（F最大值）。根据以前的研究3，对受试者的自我报告疲劳进行了测量。3 s 内缺少 Fmax （±10% MVIC） 表示工作量不足23。为了防止这个问题，应该提供口头鼓励。报告疲劳（黑线）和无疲劳（灰线）的受?...

Watch this Scientific Journal Video about Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer at JoVE.com

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

开发了简单易懂的方法，以客观和定量地测量癌症相关疲劳的运动方面。我们详细介绍了使用简单的手柄装置管理身体疲劳测试的方法，以及计算疲劳指数的方法。

使用手持测功机测量癌症相关疲劳的马达方面

Cancer-related fatigue (CRF) is commonly reported by patients both during and after receiving treatment for cancer. Current CRF diagnoses rely on ...

癌症相关疲劳严重影响患者健康相关生活质量。目前，研究人员和临床医生依靠自我报告的调查问卷来诊断这种使人衰弱的症状。本工作中概述的方法有助于以准确和客观的方式标准化物理疲劳测量。这种技术相当简单，易于适应临床使用。目前工作中提供的协议将减少对临床医生进行亲自培训的需要。展示这些程序的将是珍妮丝·里根、莎拉·阿尔沙维·约瑟芬·利旺和贾梅尔·约瑟夫，我们实验室的后背研究员。在一间安静的房间里，用扶手架架起一把椅子。打开手持式测功机。当提示时，按下按钮接受校准提示。在校准过程中，确保设备停留在平坦的表面上。手柄装置对机械力敏感。小心处理设备非常重要。将主体直立放置，双脚与地板完全接触。和臀部早在椅子支持。确保主体的臀部和膝盖角度接近 90 度。肩膀是一个中立的绑架加法和中性旋转。确保主体的肘部在 90 度下弯曲，手腕不受支撑。指导主体掌握测功机，将前向的后面中间法兰。将手柄位置调整到主体手的大小。然后记录夹紧位置。重要的是要记住，确保在整个测试过程中有适当的座椅和抓地力位置。使用每个科目的标准化脚本说明，对于此测试，该科目将尽可能用硬的挤压五秒钟。在静态疲劳测试期间，确保受试者保持最大自愿等轴收缩或 MVIC 非常重要。倒计时三，二，一，去.On Go，通过点击测功机上的"去"按钮启动程序。重复两次 MVIC 测试，总共进行三次试验，试验之间休息 30 秒。使用标准化脚本，指示主体在测试的整个 35 秒内全力完成。倒计时三，二，一，去.On Go，通过点击测功机上的"去"按钮启动程序。在 35 秒内，使用标准化脚本鼓励主题用硬挤压。35 秒后结束测试。为测功机屏幕准备透明度叠加。在表示目标值的透明度上绘制一条水平线，即 50% 的主体 MVIC。在目标值下方绘制第二行 10%。确保主体可以看到屏幕和 50% MVIC 线路。指示主体尽可能长时间地保持目标值。倒计时三个二，一，去.On Go，通过点击测功机上的"去"按钮启动程序。当力从目标值下降 10% 超过五秒钟时，停止测试。将节拍节拍设置为每秒钟一个节拍。然后开始节拍。指示主题，他们将执行最大挤压每一秒的持续时间为 30 秒。在节拍器中，倒数三，二，一个 Go.On Go，通过单击测功机上的"去"按钮启动程序。30 秒后停止测试。本研究提供了三种不同的方法来测量癌症相关的疲劳。测功机数据可用于计算疲劳指数。静态疲劳，索引版本 1 表示在没有疲劳的情况下产生的实际力和假设力之间的差值。版本 2 表示从前五秒到最后五秒的力下降。虽然两个版本都检测疲劳和非疲劳主体之间的差异，但版本 1 导致了更好的歧视和更高的测试，以重新测试可靠性。建议使用版本 1 测量癌症患者的疲劳。对于子最大疲劳指数，性能计算为总工作。非疲劳受试者表现出比疲劳受试者更高的耐力和总工作。虽然此测试通常不用于计算选民疲劳能力，但它包括，因为它经常用于诱导疲劳，并且它更好地近似于日常任务。动态疲劳指数表示间歇性收缩力从前五秒到最后五秒的下降。它还捕获疲劳和非疲劳受试者的区别。但它坚持一致的节奏的困难， 引入变异性.此外，虽然它具有良好的测试测试可靠性，在以前的研究中，它并不足以证明具有足够的鉴别力。按照此程序，可以使用自我报告问卷测量主观疲劳。使用这个程序可以进一步研究身体疲劳对整体疲劳感的影响。此外，随着时间的推移，可以收集物理疲劳数据，以检查纵向治疗效果。临床医生将能够客观地测量与癌症相关的疲劳。此外，研究人员将能够探索可能的原因机制，其基础衰弱的症状。

Research

JoVE Journal

Cancer Research

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema

乳腺癌相关的淋巴水肿的超声评价

Lymphedema is one of the most common complications after breast cancer surgery. There are many diagnostic tools for lymphedema, but no standard method yet ...

科研

癌症研究

A Mouse Model of Fatigue Induced by Peripheral Irradiation

疲劳的小鼠模型的外围照射引起

Cancer-related fatigue (CRF) is a distressing and costly condition that often affects patients receiving cancer treatments, including radiation therapy. ...

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

用球形发芽法评价 Hemangioblastoma 新生血管的体外性能的综合程序

The inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene plays a crucial role in the development of hemangioblastomas (HBs) within the human ...

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

应用 Fraumeni 综合征诱导多潜能干细胞建模骨肉瘤

Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary cancer disorder. Patients with LFS are predisposed to a various type of tumors, including ...

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

线粒体功能在癌症相关疲劳中的作用评价

Fatigue is a common and debilitating condition that affects most cancer patients. To date, fatigue remains poorly characterized with no diagnostic test to ...

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

利用卡尔瓦里亚共同培养和教条法测量骨重塑和再造肿瘤-骨微环境

Bone is a connective tissue constituted of osteoblasts, osteocytes, and osteoclasts and a mineralized extracellular matrix, which gives it its strength ...

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

使用一套实用可行的方法,描述英国皇家空军家族激酶与疾病相关的突变体

The rapidly accelerated fibrosarcoma (RAF) family kinases play a central role in cell biology and their dysfunction leads to cancers and developmental ...

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

利用有机体培养评价小鼠前列腺皮细胞的分化能力

The prostate epithelium is comprised predominantly of basal and luminal cells. In vivo lineage tracing has been utilized to define the differentiation ...

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

使用腺相关病毒-Cas9系统在Vitro建立基因工程的毛因头和颈部癌细胞系

The use of primary normal epithelial cells makes it possible to reproducibly induce genomic alterations required for cellular transformation by ...

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells

通过测量活细胞中的 eIF4E-eIF4G 交互来监控 eIF4F 装配

Formation of the eIF4F complex has been shown to be the key downstream node for the convergence of signalling pathways that often undergo&#160;oncogenic ...