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DOI :
10.3791/61024-v
April 30th, 2020
Chapters
0:04
Introduction
1:05
Measurement of the Developmental Toxicity of RAN Peptides following RNAi-based Gene Knockdown
5:38
Post-developmental RAN Peptide Paralysis Assay
8:02
Results: Toxicity of RAN Peptides
10:04
Conclusion
反復関連非ATG依存的翻訳産物は、いくつかの繰り返し拡張ベースの疾患の新たな病原性特徴である。記載されたプロトコルの目的は、モデル系C.elegansにおける行動および細胞アッセイを用いてこれらのペプチドによって引き起こされる毒性を評価することである。
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