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DOI :
10.3791/61125-v
•
15:05 min
May 20th, 2020
Chapters
0:04
Introduction
0:47
Structure Preparation
4:12
System Setup
5:17
Molecular Dynamics Simulation
7:15
Visual Inspection Analysis
8:29
Root-Mean Square Deviation (RMSD) and Root-Mean Square Fluctuation (RMSF) Analysis
9:58
Hydrogen Bond Analysis
10:57
Free Energy Calculations
12:25
Representative Results: Molecular Dynamics Simulation of EGFR Somatic Mutations
14:23
Conclusion
이 프로토콜의 목적은 분자 역학 시뮬레이션을 사용하여 EGFR 키나아제 단백질의 돌연변이를 활성화하기 때문에 발생하는 동적 구조적 변화를 검사하는 것입니다.
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