Name: morphological and functional assessment of the right ventricle using 3d echocardiography
Uploaded: 2020-10-28T13:00:00
Description: Watch this Scientific Journal Video about Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography at JoVE.com

项目编号NVKP_16-1-2016-0017（“国家心脏计划”）已在匈牙利国家研究，发展和创新基金的支持下实施，该基金由NVKP_16资助计划资助。该研究由匈牙利创新与技术部的主题卓越计划（2020-4.1.1.-TKP2020）在塞梅尔威斯大学的治疗开发和生物成像主题计划的框架内资助。

该方案遵循该机构人类研究伦理委员会的指导方针，临床病例的患者对该研究给予书面知情同意。
1. 技术要求
<ol><li>对于 3D 采集和分析，请使用适当的软件和硬件。使用超声心动图设备的心电电缆;此外，对于下面描述的完整3D采集协议，这是强制性的。</li>
	<li>对于 3D 采集，请使用 3D 超声心动图探头和兼容 3D 的超声机。对于 3D RV 体积分析，请使用专用软件。</li>
</ol><p cla...

<ol>
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L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Prognostic+value+of+right+ventricular+function+in+patients+after+acute+myocardial+infarction+treated+with+primary+percutaneous+coronary+intervention.">Prognostic value of right ventricular function in patients after acute myocardial infarction treated with primary percutaneous coronary intervention.</a> Circulation: Cardiovascular Imaging. 3 (3), 264-271 (2010).</li><li>Amsallem, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Right+Heart+End-Systolic+Remodeling+Index+Strongly+Predicts+Outcomes+in+Pulmonary+Arterial+Hypertension:+Comparison+With+Validated+Models.">Right Heart End-Systolic Remodeling Index Strongly Predicts Outcomes in Pulmonary Arterial Hypertension: Comparison With Validated Models.</a> Circulation: Cardiovascular Imaging. 10 (6), (2017).</li><li>Merlo, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+Prognostic+Impact+of+the+Evolution+of+RV+Function+in+Idiopathic+DCM.">The Prognostic Impact of the Evolution of RV Function in Idiopathic DCM.</a> JACC: Cardiovascular Imaging. 9 (9), 1034-1042 (2016).</li><li>Addetia, K., Muraru, D., Badano, L. P., Lang, R. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=New+Directions+in+Right+Ventricular+Assessment+Using+3-Dimensional+Echocardiography.">New Directions in Right Ventricular Assessment Using 3-Dimensional Echocardiography.</a> JAMA Cardiology. , (2019).</li><li>Nagata, Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Prognostic+Value+of+Right+Ventricular+Ejection+Fraction+Assessed+by+Transthoracic+3D+Echocardiography.">Prognostic Value of Right Ventricular Ejection Fraction Assessed by Transthoracic 3D Echocardiography.</a> Circulation: Cardiovascular Imaging. 10 (2), (2017).</li><li>Surkova, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Relative+Prognostic+Importance+of+Left+and+Right+Ventricular+Ejection+Fraction+in+Patients+With+Cardiac+Diseases.">Relative Prognostic Importance of Left and Right Ventricular Ejection Fraction in Patients With Cardiac Diseases.</a> Journal of the American Society of Echocardiography. 32 (11), 1407-1415 (2019).</li><li>Maffessanti, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Age-,+body+size-,+and+sex-specific+reference+values+for+right+ventricular+volumes+and+ejection+fraction+by+three-dimensional+echocardiography:+a+multicenter+echocardiographic+study+in+507+healthy+volunteers.">Age-, body size-, and sex-specific reference values for right ventricular volumes and ejection fraction by three-dimensional echocardiography: a multicenter echocardiographic study in 507 healthy volunteers.</a> Circulation: Cardiovascular Imaging. 6 (5), 700-710 (2013).</li><li>. GE 4D RVQ White Paper Available from: <a target="_blank" href="https://www.imv-imaging.com/media/5879/4d_auto_rvq_whitepaper_v8.pdf">https://www.imv-imaging.com/media/5879/4d_auto_rvq_whitepaper_v8.pdf</a> (2017)</li><li>Medvedofsky, D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Novel+Approach+to+Three-Dimensional+Echocardiographic+Quantification+of+Right+Ventricular+Volumes+and+Function+from+Focused+Views.">Novel Approach to Three-Dimensional Echocardiographic Quantification of Right Ventricular Volumes and Function from Focused Views.</a> Journal of the American Society of Echocardiography. 28 (10), 1222-1231 (2015).</li><li>Lakatos, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Quantification+of+the+relative+contribution+of+the+different+right+ventricular+wall+motion+components+to+right+ventricular+ejection+fraction:+the+ReVISION+method.">Quantification of the relative contribution of the different right ventricular wall motion components to right ventricular ejection fraction: the ReVISION method.</a> Cardiovascular Ultrasound. 15 (1), 8 (2017).</li><li>Lakatos, B. K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dominance+of+free+wall+radial+motion+in+global+right+ventricular+function+of+heart+transplant+recipients.">Dominance of free wall radial motion in global right ventricular function of heart transplant recipients.</a> Clinical Transplantation. 32 (3), e13192 (2018).</li><li>Raina, A., Vaidya, A., Gertz, Z. M., Susan, C., Forfia, P. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Marked+changes+in+right+ventricular+contractile+pattern+after+cardiothoracic+surgery:+implications+for+post-surgical+assessment+of+right+ventricular+function.">Marked changes in right ventricular contractile pattern after cardiothoracic surgery: implications for post-surgical assessment of right ventricular function.</a> Journal of Heart and Lung Transplantation. 32 (8), 777-783 (2013).</li><li>Nowak-Machen, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Regional+Right+Ventricular+Volume+and+Function+Analysis+Using+Intraoperative+3-Dimensional+Echocardiography-Derived+Mesh+Models.">Regional Right Ventricular Volume and Function Analysis Using Intraoperative 3-Dimensional Echocardiography-Derived Mesh Models.</a> Journal of Cardiothoracic and Vascular Anesthesia. 33 (6), 1527-1532 (2019).</li><li>Pettersen, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Contraction+pattern+of+the+systemic+right+ventricle+shift+from+longitudinal+to+circumferential+shortening+and+absent+global+ventricular+torsion.">Contraction pattern of the systemic right ventricle shift from longitudinal to circumferential shortening and absent global ventricular torsion.</a> Journal of the American College of Cardiology. 49 (25), 2450-2456 (2007).</li><li>Moceri, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three-dimensional+right-ventricular+regional+deformation+and+survival+in+pulmonary+hypertension.">Three-dimensional right-ventricular regional deformation and survival in pulmonary hypertension.</a> European Heart Journal - Cardiovascular Imaging. , (2017).</li><li>Addetia, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Three-dimensional+echocardiography-based+analysis+of+right+ventricular+shape+in+pulmonary+arterial+hypertension.">Three-dimensional echocardiography-based analysis of right ventricular shape in pulmonary arterial hypertension.</a> European Heart Journal - Cardiovascular Imaging. 17 (5), 564-575 (2016).</li><li>Addetia, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Morphologic+Analysis+of+the+Normal+Right+Ventricle+Using+Three-Dimensional+Echocardiography-Derived+Curvature+Indices.">Morphologic Analysis of the Normal Right Ventricle Using Three-Dimensional Echocardiography-Derived Curvature Indices.</a> Journal of the American Society of Echocardiography. 31 (5), 614-623 (2018).</li><li>Lakatos, B. 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RV 的 3D 分析是日常心脏病学实践中的重要一步。随着人们对以前被忽视的心腔的形态和功能的兴趣日益浓厚，这些新颖的解决方案提供了有关心脏右侧的临床有意义的信息。虽然3D采集有几个方面与2D超声心动图成像明显不同，但通过特别注意关键点并使用全面的协议，3D RV分析可以从科学工具发展成为超声心动图检查的重要步骤。凭借最佳的图像质量和适当的专业知识，使用超声心动图进行RV体?...

超声心动图从 1950 年代的首次临床应用开始了漫长的道路1.第一个一维超声探头旨在提供腔室壁和腔的简单线性直径;然而，它们无疑代表了心血管成像的一个里程碑。二维（2D）超声成像的发展是另一个重要步骤，它提供了更精确的形态和功能量化，并且仍然被认为是日常临床实践中的标准方法。然而，基于2D超声心动图的评估仍然存在该技术的主要局限性：从几个断层扫描平面对给定腔室的成像不能充分表征三维（3D）结构的形态和功能。这个问题在右心室 （RV） 的情况下更为明显：与相对简单的子弹形左心室 （LV） 相比，右心室具有复杂的几何形状2 ，无法使用线性直径或区域3 充分量化。尽管有这些广为人知的事实，但RV的形态和功能通常在临床实践中通过这些简单的参数来测量。
几十年来，与左翼对应物相比，RV 被认为在流通中的作用要小得多。几篇具有里程碑意义的论文推翻了这一观点，表明RV几何形状和功能在多种疾病中的强烈预后作用4，5，6，7。大量研究表明，即使使用相对简单的常规参数，RV测量的增量价值也突出了对具有潜在有意义的临床价值的腔室进行更精确定量的重要性和需求。
3D超声心动图克服了心腔2D评估的几个局限性。虽然在LV的情况下，没有几何假设的体积和功能参数的测量也可能引起高度关注，但在RV8的评估中可能变得特别重要。3D 衍生的右心室体积和射血分数 （EF） 在各种心血管疾病中具有显着的预后价值9，10。
如今，一些供应商提供用于 3D RV 评估的半自动解决方案，并根据金标准心脏磁共振 （MR） 测量结果验证结果11，12。3D评估的技术要求是当今最先进的心血管成像部门的重要组成部分，预计它很快就会成为每个超声心动图实验室通用设备的一部分。凭借在3D采集和后处理方面的适当专业知识，3D RV分析可以很容易地实施到标准检查方案中。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>3V-D/4V-D/4Vc-D</td>
			<td>General Electric</td>
			<td>n.a.</td>
			<td>ultrasound probe</td>
		</tr>
		<tr>
			<td>4D Auto RVQ</td>
			<td>General Electric</td>
			<td>n.a.</td>
			<td>software for analysis</td>
		</tr>
		<tr>
			<td>E9/E95</td>
			<td>General Electric</td>
			<td>n.a.</td>
			<td>ultrasound machine</td>
		</tr>
		<tr>
			<td>EchoPac v203</td>
			<td>General Electric</td>
			<td>n.a.</td>
			<td>software for analysis</td>
		</tr>
	</tbody>
</table>

morphological and functional assessment of the right ventricle using 3d echocardiography

传统上，人们认为心脏的右侧在循环中起着次要的作用;然而，越来越多的数据表明，右心室（RV）功能对各种心血管疾病具有很强的诊断和预后能力。由于其复杂的形态和功能，通过传统的二维超声心动图评估RV是有限的：日常临床实践通常依赖于简单的线性尺寸和功能测量。三维 （3D） 超声心动图克服了这些限制，提供了不受几何假设影响的 RV 体积定量。在这里，我们提供了一个分步指南，使用领先的商用软件获取和分析RV的3D超声心动图数据。我们将量化 3D RV 体积和射出分数。几个技术方面也可能有助于提高RV采集和分析的质量，我们以实用的方式介绍。我们回顾了该方法的当前机会和限制因素，并强调了3D RV评估在当前临床实践中的潜在应用。

RV 的 3D 分析在各种心血管疾病中是可行的。病例1是一名健康的志愿者，心室容量和功能正常（图1）。病例 2 是一名二尖瓣修复术后患者，他是传统 2D 评估结果相互矛盾的典型示例：虽然 TAPSE 明显降低，但患者未表现出任何右心室功能障碍的迹象，并且 3D RV EF 正常证实右心室整体收缩功能维持（图 2）。两位患者都有出色的?...

Watch this Scientific Journal Video about Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography at JoVE.com

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

在这里，我们为右心室的3D体积评估提供了一步一步的采集和分析方案，主要侧重于最大化该技术可行性的实际方面。

使用3D超声心动图对右心室进行形态学和功能评估

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经胸超声心动图在小鼠

In recent years, murine models have become the primary avenue for studying the molecular mechanisms of cardiac dysfunction resulting from changes in gene ...

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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

磁共振衍生的心肌劳损评估使用特征跟踪

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Echocardiographic Assessment of the Right Heart in Mice

右心小鼠的超声心动图评价

Transgenic and toxic models of pulmonary arterial hypertension (PAH) are widely used to study the pathophysiology of PAH and to investigate potential ...

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右心室结构和功能的肺动脉缩窄经胸超声小鼠模型的评估

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心肌梗死和功能预后评估的猪

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An original piglet model of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) associated with chronic Right Ventricular (RV) dysfunction is described. ...

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

在横向主动脉缩窄的小鼠模型和心脏形态学评估功能改变通过超声心动图成像

Transverse aortic constriction (TAC) in mice has been used as a valuable model to study mechanisms of cardiac hypertrophy and heart failure1. A reliable ...

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

经胸斑点跟踪超声心动图左室心肌变形的定量评价

The value of conventional echocardiography is limited by differences in inter-individual image interpretation and therefore largely dependent on the ...

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

3D 细胞培养和非抗凝全血对内皮细胞抗凝及抗炎作用的评价

In vivo, endothelial cells are crucial for the natural anticoagulation of circulating blood. Consequently, endothelial cell activation leads to blood ...

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axolotl 中的二维和三维超声心动图

Cardiac malfunction as a result of ischemic heart disease is a major challenge, and regenerative therapies to the heart are in high demand. A few model ...