Delivery and Care of Offspring and Intestinal Harvesting
3:03
Intestinal Injury Scoring
4:11
Quantification of Paneth and Goblet Cells
6:35
Results: Intestinal Injury of Newborn Mice Induced by FEMI
8:22
Conclusion
Transcript
This FEMI protocol makes it possible to investigate long-term effects to neonates following fetal exposure to maternal inflammation. This is especially relevant for development of necrotizing enterocolitis, or NEC. This technique mimics sterile in
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We developed a model of chorioamnionitis to simulate fetal exposure to maternal inflammation (FEMI) without complications of live organisms to examine the effects of FEMI on development of the offspring’s intestinal tract. This allows for study of mechanistic causes for development of intestinal injury following chorioamnionitis.