Name: simultaneous monitoring of wireless electrophysiology and memory behavioral test as a tool to study hippocampal neurogenesis
Uploaded: 2020-08-20T13:00:00
Duration: 7 min 25 s
Description: Watch this Scientific Journal Video about Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis Video at JoVE.com

हम तकनीकी सहायता प्रदान करने के लिए श्री मिगुएल बर्गोस, और श्री गुस्तावो लागो को धन्यवाद देना चाहते हैं। हम वीडियो उत्पादन लागत को कवर करने के लिए स्टोल्टिंग कंपनी के आभारी हैं, तकनीकी सहायता प्रदान करने के लिए जिंगा-ही, इंक, और इस काम के लिए धन देने के लिए Universidad Iberoamericana Ciudad de México के डिविज़न डी इन्वेस्टिगासियोन वाई पोस्ग्राडो।

<ol>
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J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Erratum:+Neurogenesis+in+the+adult+is+involved+in+the+formation+of+trace+memories+(Nature+(2001)+410+(372-376)).">Erratum: Neurogenesis in the adult is involved in the formation of trace memories (Nature (2001) 410 (372-376)).</a> Nature. 414 (6866), 938 (2001).</li><li>Song, H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=New+neurons+in+the+adult+mammalian+brain:+Synaptogenesis+and+functional+integration.">New neurons in the adult mammalian brain: Synaptogenesis and functional integration.</a> Journal of Neuroscience. 25 (45), 10366-10368 (2005).</li><li>Zhao, C., Teng, E. M., Summers, R. G., Ming, G. L., Gage, F. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Distinct+morphological+stages+of+dentate+granule+neuron+maturation+in+the+adult+mouse+hippocampus.">Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus.</a> Journal of Neuroscience. 26 (1), 3-11 (2006).</li><li>Irvine, G. I., Logan, B., Ecket, M., Abraham, W. C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Enriched+environment+exposure+regulates+excitability,+synaptic+transmission,+and+LTP+in+the+dentate+gyrus+of+freely+moving+rats.">Enriched environment exposure regulates excitability, synaptic transmission, and LTP in the dentate gyrus of freely moving rats.</a> Hippocampus. 16 (2), 149-160 (2006).</li><li>Tashiro, A., Makino, H., Gage, F. 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J., Stackman, R. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessing+rodent+hippocampal+involvement+in+the+novel+object+recognition+task.+A+review.">Assessing rodent hippocampal involvement in the novel object recognition task. A review.</a> Behavioural Brain Research. 285, 105-117 (2015).</li><li>Fagan, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Memory+in+the+infant.">Memory in the infant.</a> Journal of Experimental Child Psychology. 9 (2), 217-226 (1970).</li><li>Baxter, M. 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Theoretical comment on Burke et al.</a> Behavioral Neuroscience. 124 (5), 706-709 (2010).</li><li>Antunes, M., Biala, G. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+novel+object+recognition+memory:+Neurobiology,+test+procedure,+and+its+modifications.">The novel object recognition memory: Neurobiology, test procedure, and its modifications.</a> Cognitive Processing. 13 (2), 93-110 (2012).</li><li>Ennaceur, A., Delacour, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+new+one-trial+test+for+neurobiological+studies+of+memory+in+rats.+1:+Behavioral+data.">A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.</a> Behavioural Brain Research. 31 (1), 47-59 (1988).</li><li>Winters, B. D., Forwood, S. E., Cowell, R. A., Saksida, L. M., Bussey, T. 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J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Hippocampal+lesions+that+abolish+spatial+maze+performance+spare+object+recognition+memory+at+delays+of+up+48+hours.">Hippocampal lesions that abolish spatial maze performance spare object recognition memory at delays of up 48 hours.</a> Hippocampus. 15 (3), 347-355 (2005).</li><li>Paxinos, G., Watson, C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=.">.</a> The rat brain in stereotaxic coordinates. , (1997).</li><li>. Getting started with ANY-maze Setting up and starting work with ANY-maze Available from: <a target="_blank" href="https://www.braintreesci.com/images/ANYMaze.pdf">https://www.braintreesci.com/images/ANYMaze.pdf</a> (2006)</li><li>. A detailed description of the ANY-maze measures Available from: <a target="_blank" href="https://www.braintreesci.com/images/ANYMaze.pdf">https://www.braintreesci.com/images/ANYMaze.pdf</a> (2010)</li></ol>

सिल्विया ओर्टेगा-मार्टिनेज स्टोल्टिंग कंपनी के एक कर्मचारी के रूप में काम करता है, एक कंपनी जिसने इस लेख के उत्पादन और खुली पहुंच प्रदान की और प्रायोजित की।

<table>
	<tbody>
		<tr>
			<td>#2 Variable speed rotary tool tip</td>
			<td>Reorder #310048, Lenght 44.5mm</td>
			<td>SS White</td>
			<td>For making the holes where the screws will be inserted</td>
		</tr>
		<tr>
			<td>#4 Scalpel and blade</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>50 X 50 X 50 cm Open Field Black Mate Arena</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>8 pin Receptacle Housing Female</td>
			<td>Amphenol FCI</td>
			<td>10147606-00008LF</td>
			<td></td>
		</tr>
		<tr>
			<td>8 pin Receptacle Housing Male</td>
			<td>Amphenol FCI</td>
			<td>10147603-00008LF</td>
			<td></td>
		</tr>
		<tr>
			<td>Acrylic Resin</td>
			<td>MDC Dental</td>
			<td>NicTone</td>
			<td>For fixating the screws to the skull</td>
		</tr>
		<tr>
			<td>ANY-maze video tracking software</td>
			<td>Stoelting, Co.</td>
			<td>version 6.1</td>
			<td>http://www.anymaze.co.uk/)</td>
		</tr>
		<tr>
			<td>benzalkonium chloride antiseptic solution</td>
			<td>Benzal</td>
			<td>Benzal</td>
			<td></td>
		</tr>
		<tr>
			<td>Bulldog clamps</td>
			<td>Cientifica VelaQuin</td>
			<td></td>
			<td>For retracting the skin</td>
		</tr>
		<tr>
			<td>Camera</td>
			<td>Logitech</td>
			<td>c920</td>
			<td></td>
		</tr>
		<tr>
			<td>Copper wire</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Crimp contact</td>
			<td>Amphenol FCI</td>
			<td>10147604-01LF</td>
			<td></td>
		</tr>
		<tr>
			<td>DELL PC</td>
			<td>DELL</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Electrode</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>JAGA16</td>
			<td>Jinga-Hi, Inc.</td>
			<td>JAGA16</td>
			<td></td>
		</tr>
		<tr>
			<td>Ketamine</td>
			<td>PiSA Agropecuaria</td>
			<td>ANESKET</td>
			<td>For anesthesia</td>
		</tr>
		<tr>
			<td>MATLAB</td>
			<td>R2020a</td>
			<td>MathWorks</td>
			<td>Script was develop ped in collaboration with Jinga-Hi, Inc.</td>
		</tr>
		<tr>
			<td>Monomer</td>
			<td>MDC Dental</td>
			<td>NicTone</td>
			<td>For fixating the screws to the skull</td>
		</tr>
		<tr>
			<td>Neurophys software</td>
			<td>Jinga-Hi, Inc./ Neurosys, LLC</td>
			<td>Neurosys 3.0.0.7</td>
			<td></td>
		</tr>
		<tr>
			<td>Screwdrive</td>
			<td></td>
			<td></td>
			<td>For inserting the screws into the skull</td>
		</tr>
		<tr>
			<td>Screws</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Screws equiped with electrode</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Stereotaxic instrument</td>
			<td>KOPF</td>
			<td></td>
			<td>For the surgery</td>
		</tr>
		<tr>
			<td>Variable speed rotary tool</td>
			<td>Dremel 3000</td>
			<td>Dremel</td>
			<td>For making the holes where the screws will be inserted</td>
		</tr>
		<tr>
			<td>Voltmeter</td>
			<td>PROAM</td>
			<td>MUL-040</td>
			<td>For confirming that the electrode conducts electricity</td>
		</tr>
		<tr>
			<td>Xilazine</td>
			<td>PiSA Agropecuaria</td>
			<td>PROCIN</td>
			<td>For anesthesia</td>
		</tr>
	</tbody>
</table>

simultaneous monitoring of wireless electrophysiology and memory behavioral test as a tool to study hippocampal neurogenesis

इलेक्ट्रोएन्सेफलोग्राफी (ईईजी) से प्राप्त ब्रेनवेव्स आयाम को जानवरों और मनुष्यों पर संज्ञानात्मक क्षमता, स्मृति और सीखने के आधार के रूप में अच्छी तरह से मान्यता प्राप्त है। वयस्क न्यूरोजेनेसिस तंत्र भी स्मृति और सीखने के सुधार से जुड़ा हुआ है। परंपरागत रूप से, शोधकर्ता व्यवहार कार्यों द्वारा कृंतक मॉडल में सीखने और स्मृति मापदंडों का आकलन करते थे। इसलिए, व्यवहार परिवर्तन और ईईजी की एक साथ निगरानी मस्तिष्क गतिविधि और कार्य से संबंधित व्यवहारों के बीच डेटा को सहसंबंधित करने में विशेष रूप से दिलचस्प है। हालांकि, दोनों अध्ययनों को करने के लिए आवश्यक अधिकांश उपकरण या तो जटिल, महंगे हैं, या एक वायर्ड सेटअप नेटवर्क का उपयोग करते हैं जो प्राकृतिक जानवरों के आंदोलन में बाधा डालता है। इस अध्ययन में, ईईजी को एक नवीन वस्तु पहचान कार्य (एनओआरटी) के निष्पादन के साथ एक वायरलेस इलेक्ट्रोफिजियोलॉजी डिवाइस के साथ दर्ज किया गया था। एक वीडियो ट्रैकिंग सिस्टम द्वारा एक साथ जानवर के व्यवहार की निगरानी की गई थी। दोनों रिकॉर्डिंग का विश्लेषण उनके टाइमस्टैम्प द्वारा ऑफ़लाइन किया गया था जो ईईजी संकेतों को जानवर के कार्यों के साथ जोड़ने के लिए सिंक किए गए थे। विषयों में मध्यम अवधि के पर्यावरण संवर्धन उपचार के बाद वयस्क विस्टार चूहे शामिल हैं। छह खोपड़ी स्क्रू इलेक्ट्रोड को ललाट, मध्य और पार्श्विका क्षेत्रों में दोनों गोलार्धों पर जोड़े में तय किया गया था और नाक की हड्डी के पीछे स्थित इलेक्ट्रोड को संदर्भित किया गया था। एनओआरटी प्रोटोकॉल में जानवर को 10 मिनट के लिए दो समान वस्तुओं को उजागर करना शामिल है। 2 घंटे और 24 घंटे के बाद, वस्तुओं में से एक को एक उपन्यास के साथ बदल दिया गया था। प्रत्येक ऑब्जेक्ट के लिए अन्वेषण समय की निगरानी एक व्यवहार ट्रैकिंग सॉफ्टवेयर (बीटीएस) और ईईजी डेटा रिकॉर्डिंग द्वारा की गई थी। व्यवहार डेटा के साथ सिंक किए गए ईईजी के विश्लेषण में अल्फा और बीटा सापेक्ष बैंड शक्ति के अनुमान और तीन प्रयोगात्मक चरणों के बीच उपन्यास वस्तु पहचान बनाम परिचित वस्तु अन्वेषण के बीच तुलना शामिल है। इस पांडुलिपि में, हमने इलेक्ट्रोड निर्माण प्रक्रिया, एपिड्यूरल इलेक्ट्रोड प्रत्यारोपण सर्जरी, पर्यावरण संवर्धन प्रोटोकॉल, एनओआरटी प्रोटोकॉल, बीटीएस सेटअप, ईईजी - बीटीएस युग्मन वास्तविक समय में एक साथ निगरानी के लिए और स्वचालित घटनाओं का पता लगाने के आधार पर ईईजी डेटा विश्लेषण पर चर्चा की है।

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Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis Video (Video) | JoVE

यहां प्रस्तुत प्रोटोकॉल वास्तविक समय में एक साथ इलेक्ट्रोएन्सेफलोग्राफी (ईईजी) और व्यवहार मूल्यांकन पर जानकारी प्रदान करता है। हमने तंत्रिका विज्ञान के कई क्षेत्रों में शोधकर्ताओं के लिए एक आकर्षक समाधान के रूप में इस प्रोटोकॉल में शामिल सभी चरणों पर चर्चा की है, विशेष रूप से सीखने और स्मृति क्षेत्रों में।

हिप्पोकैम्पल न्यूरोजेनेसिस का अध्ययन करने के लिए एक उपकरण के रूप में वायरलेस इलेक्ट्रोफिजियोलॉजी और मेमोरी बिहेवियरल टेस्ट की एक साथ निगरानी

Brainwaves amplitude obtained from electroencephalography (EEG) has been well-recognized as a basis for cognitive capacity, memory, and learning on ...

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Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis

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