Name: measurement of tissue oxygenation using near-infrared spectroscopy in patients undergoing hemodialysis
Uploaded: 2020-10-02T13:00:00
Description: Watch this Scientific Journal Video about Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis at JoVE.com

Vi takker dialyse staber og medlemmer av institutt for nefrologi i Saitama medisinske senter Jichi Medical University. Vi vil gjerne takke Editage (www.editage.com) for engelskspråklig redigering.

Alle deltakerne ga skriftlig informert samtykke. Studien ble godkjent av Institutional Review Board ved Saitama Medical Center, Jichi Medical University, Japan (RIN 15–104).
1. Enhet for overvåking av rSO2
<ol><li>Forbered en NIRS-enhet for måling av oksygenering av vev. Denne enheten har fire kanaler og kan utføre måling i opptil fire organer samtidig.</li>
	<li>Klargjør en målesensor for NIRS-overvåking, for å evaluere rSO2-verdier i hvert organ ved overfør...

<ol>
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NIRS-overvåking har hovedsakelig blitt brukt til å evaluere cerebral rSO2, spesielt ved kardiovaskulære eller cerebrovaskulære operasjoner, som krever ekstrakorporeal sirkulasjon. Under ekstrakorporeal sirkulasjon inkludert HS-behandling, kunne noen organer vise relativ iskemi 7,17,18; Det er imidlertid fortsatt uklart om oksygenering av vev blir lav eller ikke. Muskelkramper eller magesmerter under HS kan være e...

Nær-infrarød spektroskopi (NIRS) har blitt brukt til å evaluere regional oksygenmetning (rSO 2), en markør for vevsoksygenering, spesielt cerebral oksygenering i ulike kliniske innstillinger 1,2,3 og har nylig blitt brukt på pasienter som gjennomgår hemodialyse (HD)4,5,6,7,8,9,10, 11. Cerebral rSO2 er angivelig assosiert med kognitiv funksjon hos pasienter som gjennomgår HS eller de med ikke-dialysert kronisk nyresykdom (CKD)11,12. Men så langt har bruken av NIRS-overvåking vært begrenset hos pasienter med CKD.
Siden NIRS-overvåking er sanntids- og ikke-invasiv, vurderte vi nytten som overvåkingsenhet hos pasienter som gjennomgår HS. Selv om NIRS hovedsakelig brukes til å måle cerebral rSO 2, undersøkte vi også rSO 2-verdier i andre organer under HS. Spesielt ble rSO 2-målesensorene festet til pannen, høyre hypokondrium og underben for å evaluere rSO 2 i henholdsvis hjernen, leveren og nedre muskler. Resultatene viste at NIRS-overvåking kan være en ny tilnærming for å avklare endringer i organoksygenering under HS eller faktorer som påvirker oksygenering av vev hos CKD-pasienter.
Til dags dato ble kontinuerlig overvåking utført under HS, blodvolumovervåking, sentral venøs oksygenmetning, thoraxinnleggelse og elektronisk stetoskopstyrt estimert blodtrykk (BP) i kliniske omgivelser13,14,15; Det er imidlertid begrensninger for prediksjon av hypotensjon eller bred bruk av enheter. I motsetning til dette kan den nye ikke-invasive tilnærmingen her gi sanntidsinformasjon om intradialytisk oksygendynamikk i individuelle organer. Derfor kan denne overvåkingsmetoden gjøre det mulig å oppdage forbigående organiskemi i de tidlige fasene av intradialytisk hypotensjon, og kan også muliggjøre sikker utførelse av HS. Denne artikkelen beskriver en protokoll for å måle oksygenering av vev representert ved rSO2, slik den brukes hos pasienter som gjennomgår HS.

<table>
	<tbody>
		<tr>
			<td>DBB-100NX</td>
			<td>Nikkiso</td>
			<td>DBB-100NX</td>
			<td>Dialysis machine</td>
		</tr>
		<tr>
			<td>INVOS 5100c</td>
			<td>Covidien Japan</td>
			<td>INVOSTM 5100c</td>
			<td>tissue oxygenation device</td>
		</tr>
		<tr>
			<td>SOMASENSER</td>
			<td>Covidien Japan</td>
			<td>CV-SAFB-SM/INTL</td>
			<td>NIRS sensor</td>
		</tr>
	</tbody>
</table>

measurement of tissue oxygenation using near-infrared spectroscopy in patients undergoing hemodialysis

Nær-infrarød spektroskopi (NIRS) har nylig blitt brukt som et verktøy for å måle regional oksygenmetning (rSO2), en markør for oksygenering av vev, i kliniske innstillinger, inkludert kardiovaskulær og hjernekirurgi, neonatal overvåking og prehospital medisin. NIRS-overvåkingsenhetene er sanntids- og ikke-invasive, og har hovedsakelig blitt brukt til å evaluere cerebral oksygenering hos kritisk syke pasienter under en operasjon eller intensivbehandling. Så langt har bruken av NIRS-overvåking hos pasienter med kronisk nyresykdom (CKD) inkludert hemodialyse (HD) vært begrenset; Derfor undersøkte vi rSO2-verdier i noen organer ved HS. Vi overvåket rSO 2-verdier ved hjelp av en NIRS-enhet som overfører nær-infrarødt lys ved2 bølgelengder av vedlegg. HS-pasientene ble plassert i liggende stilling, med rSO 2 målesensorer festet til pannen, riktig hypokondrium og leggene for å evaluere rSO2 i henholdsvis hjernen, leveren og leggmuskulaturen. NIRS-overvåking kan være en ny tilnærming for å avklare endringer i organoksygenering under HS eller faktorer som påvirker oksygenering av vev hos CKD-pasienter. Denne artikkelen beskriver en protokoll for å måle vevsoksygenering representert ved rSO2 som anvendt på HS-pasienter.

Cerebrale rSO 2-verdier før HS var lavere enn hos friske personer, og cerebral rSO2 hos HS-pasienter med diabetes mellitus (DM) var lavere enn hos HS-pasienter uten DM (figur 1)16. Videre, selv om vevsoksygenering fortsetter uten reduksjon av BT under HS, observerte vi tilfeldigvis endringer i cerebral og hepatisk rSO 2 på grunn av intradialytisk hypotensjon (figur 2). På grunn av den kontinuerlige over...

Watch this Scientific Journal Video about Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis at JoVE.com

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Vi presenterer en protokoll for å måle regional oksygenmetning (rSO2) hos hemodialyse (HS) pasienter ved hjelp av en nær-infrarød spektroskopimonitor. rSO2-verdien er en indeks for oksygenering av vev. Denne ikke-invasive overvåkningen i sanntid kan være nyttig for å bekrefte endringer i organoksygenering under HS.

Måling av oksygenering av vev ved bruk av nær-infrarød spektroskopi hos pasienter som gjennomgår hemodialyse

Near-infrared spectroscopy (NIRS) has recently been applied as a tool to measure regional oxygen saturation (rSO2), a marker of tissue oxygenation, in ...

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