Overvågning af neutrofil elastase og cathepsin G-aktivitet i humane sputumprøver
May 21st, 2021
•1Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 2Dept. of Translational Pulmonology, University of Heidelberg, 3Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), University of Heidelberg, 4Faculty of Biosciences, Collaboration for Joint Ph.D. Degree between EMBL and Heidelberg University, University of Heidelberg, 5Dept. of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité – Universitätsmedizin Berlin, 6Berlin Institute of Health (BIH), 7German Center for Lung Research (DZL), Associated Partner Site, Berlin, 8Dept. of Chemical Physiology and Biochemistry, Oregon Health and Science University
De beskrevne protokoller indeholder en guide til at visualisere og kvantificere aktiviteten af neutrofile proteaser i menneskeligt spyt. Anvendelsen af en sådan analyse spænder fra evaluering af antiinflammatoriske behandlinger til biomarkørvalidering, lægemiddelscreening og store kliniske kohorteundersøgelser.
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