Name: motor dual-tasks for gait analysis and evaluation in post-stroke patients
Uploaded: 2021-03-11T15:00:00
Description: Watch this Scientific Journal Video about Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients at JoVE.com

我们感谢Anniwaer Yilifate校对我们的手稿。本研究由国家自然科学基金第81902281号和第82072544号基金、广州市卫生和计划生育委员会通用指导项目（批准号：20191A011091和20211A011106）、广州重点实验室基金（第201905010004号）和广东省基础与应用基础研究基金（批准号：2020A1515010578）资助。

注：临床研究经广州医科大学附属第五医院医学伦理协会批准（编号：KY01-2019-02-27），并已在中国临床试验注册中心注册（编号：KY01-2019-02-27）。ChiCTR1800017487，标题为“中风后步态控制和运动认知的多种模态任务”）。
1. 招聘
<ol><li>招募具有以下纳入标准的脑卒中患者：符合中华医学会神经分会脑血管疾病诊断标准的患者（2005）;通过计算机断层扫描或磁共振成像确诊脑梗...

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本研究描述了一种临床评估运动控制缺陷中风患者双运动任务步态分析的方案。该协议的设计基于两个要点。首先，以往的研究大多使用单一的步行任务来评估脑卒中患者的步态功能，关于运动控制的相关讨论不充分，特别是因为复杂运动的原理很少涉及22,23。因此，在这项研究中，作者除了以单步行任务为基准外，主要关注运动表现和行走两个双重任...

恢复独立行走功能是脑卒中后患者参与社区生活的必备条件之一1。行走能力的恢复不仅需要感知和认知系统的相互作用，还需要运动控制2,3,4。此外，在现实的社区生活中，人们需要更高的能力，例如同时执行两项或多项任务（例如，拿着物体行走或越过障碍物）。因此，研究开始关注双重任务对步态表现的干扰5,6。以前的双任务研究主要针对老年和认知障碍患者，因为中风患者的运动表现困难和异质性;卒中患者的步态功能主要通过单个步行任务7,8,9进行评估。然而，双任务步态分析，特别是与运动控制相关的运动双任务分析需要进一步研究。
本研究介绍了一种双运动任务步态分析和评估方法。该方案不仅包括对中风患者行走能力的临床评估，而且还侧重于两个双运动任务：保持水和行走任务（简单的双运动任务）和穿越障碍物行走任务（复杂的双运动任务）。本研究旨在探讨双运动任务对脑卒中患者步态的影响，并利用双任务参数的双任务步态成本（DTC）值10 （单任务与双任务之间的差异）来排除脑卒中患者的异质性。实验任务的设计促进了脑卒中患者运动控制功能的深入探讨，为脑卒中患者步态功能的临床诊断和评价提供了新的思路。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>BTS Smart DX system</td>
			<td>Bioengineering Technology System, Milan, Italy</td>
			<td>1</td>
			<td>Temporospatial data collection</td>
		</tr>
		<tr>
			<td>BTS SMART-Clinic software</td>
			<td>Bioengineering Technology System, Milan, Italy</td>
			<td>2</td>
			<td>Data processing</td>
		</tr>
		<tr>
			<td>SPSS software (version 25.0)</td>
			<td>IBM Crop., Armonk, NY, USA</td>
			<td></td>
			<td>Statistical analysis</td>
		</tr>
	</tbody>
</table>

motor dual-tasks for gait analysis and evaluation in post-stroke patients

本研究招募了18名中风患者，涉及认知和行走能力的评估以及多任务步态分析。多任务步态分析包括单个步行任务（任务 0）、简单运动双任务（持水，任务 1）和复杂运动双任务（穿越障碍物，任务 2）。穿越障碍物的任务被认为等同于简单的步行任务和复杂的运动任务的组合，因为它涉及更多的神经系统、骨骼运动和认知资源。为了消除脑卒中患者步态分析结果的异质性，计算了各种运动学参数的双任务步态成本值。在近端关节角度方面观察到主要差异，特别是在躯干、骨盆和髋关节的角度方面，双运动任务明显大于单步行任务。本研究方案旨在通过对双运动行走任务的分析，为步态功能的临床诊断和运动控制缺陷脑卒中患者的运动控制的深入研究提供依据。

本研究招募了18名脑卒中后偏瘫患者。参与者的平均年龄为51.61岁±12.97岁;都是男性。左右偏瘫比例为10/8;布伦斯特罗姆阶段的平均分期为4.50±0.76。MMSE和MoCA的平均值分别为26.56±1.67和20.06±2.27。其他人口统计学特征（包括脑卒中类型和发病时间）见表1。对于步态双重任务（任务1和任务2）的原始数据，时空参数没有统计学差异（表2）。然而，在关节角参数中，任务 2 中的双边躯干旋转?...

Watch this Scientific Journal Video about Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients at JoVE.com

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients

本文提出了一种专门用于运动控制缺陷中风患者双运动任务步态分析的方案。

用于中风后患者步态分析和评估的运动双任务

Eighteen stroke patients were recruited for this study involving the evaluation of cognition and walking ability and multitask gait analysis. Multitask ...

本实验任务的设计有助于深入探讨脑卒中患者运动控制功能，为脑卒中患者步态功能的临床诊断和评估提供新思路。本研究方案旨在通过双运动工作任务和双任务步态成本值的计算，为脑卒中患者步态功能的临床诊断和运动控制的深入研究提供依据。演示该程序的将是我实验室的Shijuan Lang医生和研究生Biyi Zhao和Yongchun Jiang。首先，招募中风患者并在开始研究之前获得所有患者的书面知情同意。记录患者的人口统计特征，包括姓名、性别、出生日期、教育水平、主诉、当前病史、既往病史、医疗和当前用药情况。然后要求患者完成蒙特利尔认知评估中的小型精神状态检查。接下来，进行 10 米步行测试，要求患者以自选速度进行连续三次试验，分别以确保安全性、舒适性和更高的速度。记录每次试验中步行到中间六米所需的时间。接下来，进行定时“向上和走”测试，要求患者以自选的速度进行三次连续试验，以确保安全和舒适。在进行3D步态分析之前，请告知患者注意事项和实验目的。然后，记录各种人体测量指标的值，包括身高、体重、踝关节双侧宽度、双侧膝盖直径、骨盆宽度、双侧骨盆深度和双侧腿长。接下来，患者关键点有二十二个标记，躯干上有三个标记，骨盆上有三个标记，大腿上有六个标记，小腿上有六个标记，脚上有四个标记。指导患者在测力板上保持直立位置至少三到五秒钟，以收集基线数据。然后，要求患者以自选的舒适速度在步行通行证上行走五次试验，标记为任务 0“将单个步行任务视为基线任务。接下来，要求患者在步行通行证上拿着一瓶水以自我选择的舒适速度进行五次试验。并将其标记为任务1“最后，要求患者以自选的舒适速度穿过步行通道中间的线进行五次试验，并将其标记为任务2”本研究中招募的18名中风后偏瘫患者的人口统计学特征在这里显示为简单运动双任务的原始数据， 称为任务1“和复杂电机双任务，称为任务2”时空参数没有统计差异。然而，在关节角参数中，任务2的双侧躯干旋转和横向平面的双侧骨盆旋转明显大于任务1。对于步态双重任务的DTC值，任务2的额面双侧躯干倾角和横向面的双侧骨盆旋转均高于任务1。同时，与任务 1 相比，任务 2 中正确 GPS 中的正确节奏显着增加。在这项研究中，除了以单一步行任务为基线外，我们主要比较运动表现和行走这两个双重任务，包括持水任务和冲障任务。本研究旨在探讨双模态任务对脑卒中患者步态的影响，并利用双模态参数的DTC值来积累脑卒中患者之间的异质性。这一结果表明，DTC值在评估卒中患者的双任务步态方面具有优势。

Research

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可视化和遗传操作在小鼠大脑皮层和使用海马树突和棘<em&gt;在子宫内</em&gt;电穿孔

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In animals with large  identified neurons (e.g. mollusks), analysis of motor pools is done using  intracellular techniques1,2,3,4. Recently,  we developed ...

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation

人机界面集成的低成本传感器，具有神经肌肉电刺激系统中风后康复平衡

A stroke is caused when an artery carrying blood from heart to an area in the brain bursts or a clot obstructs the blood flow to brain thereby preventing ...

Automated Gait Analysis in Mice with Chronic Constriction Injury

慢性压迫性损伤小鼠步态的自动分析

The von Frey test is a classical method that has been widely used to examine the sensory function of neuropathic pain animals. However, it has some ...

Quantitative Cell Biology of Neurodegeneration in Drosophila Through Unbiased Analysis of Fluorescently Tagged Proteins Using ImageJ

Quantitative Cell Biology of Neurodegeneration in Drosophila Through Unbiased Analysis of Fluorescently Tagged Proteins Using ImageJ

荧光标记蛋白 ImageJ 的无偏分析在果蝇变性定量细胞生物学中的应用

With the rising prevalence of neurodegenerative diseases, it is increasingly important to understand the underlying pathophysiology that leads to neuronal ...

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

小鼠二次运动皮质中双边局部场电位记录半球横向化评价

This article demonstrates complete, detailed procedures for both in vivo bilateral recording and analysis of local field potential (LFP) in the cortical ...

3D Kinematic Analysis for the Functional Evaluation in the Rat Model of Sciatic Nerve Crush Injury

坐骨神经粉碎损伤大鼠模型中功能评估的3D运动学分析

Compared to the Sciatic Functional Index (SFI), kinematic analysis is a more reliable and sensitive method for performing functional evaluations of ...

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

测量一组啮齿动物脑样本中的中风后脑水肿、梗塞区和血脑屏障破裂

One of the most common causes of morbidity and mortality worldwide is ischemic stroke. Historically, an animal model used to stimulate ischemic stroke ...

Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury

自动步态分析，评估带外周神经或脊髓挫伤的啮齿动物的功能恢复

Peripheral and central nerve injuries are mostly studied in rodents, especially rats, given the fact that these animal models are both cost-effective and ...