JoVE Logo
Faculty Resource Center

Sign In

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

DOI :

10.3791/62709-v

May 31st, 2021

May 31st, 2021

2,912 Views

1Department of Biological Sciences, University of Notre Dame, 2Center for Zebrafish Research, University of Notre Dame, 3Center for Stem Cells and Regenerative Medicine, University of Notre Dame

We modified the Marmarou weight drop model for adult zebrafish to examine a breadth of pathologies following blunt-force traumatic brain injury (TBI) and the mechanisms underlying subsequent neuronal regeneration. This blunt-force TBI model is scalable, induces a mild, moderate, or severe TBI, and recapitulates injury heterogeneity observed in human TBI.

Tags

Scalable Model

-- Views

Related Videos

article

An Optic Nerve Crush Injury Murine Model to Study Retinal Ganglion Cell Survival

article

Micromanipulation of Gene Expression in the Adult Zebrafish Brain Using Cerebroventricular Microinjection of Morpholino Oligonucleotides

article

Electrophysiological Recording in the Brain of Intact Adult Zebrafish

article

Stab Wound Injury of the Zebrafish Adult Telencephalon: A Method to Investigate Vertebrate Brain Neurogenesis and Regeneration

article

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo

article

A Novel In Vitro Model of Blast Traumatic Brain Injury

article

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

article

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

article

Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke

article

Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved