Name: comparing objective conjunctival hyperemia grading and the ocular surface disease index score in dry eye syndrome during covid-19
Uploaded: 2022-05-25T13:00:00
Description: Watch this Scientific Journal Video about Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19 at JoVE.com

我们要感谢所有参与者在填写调查问卷和发送眼睛图像方面的帮助和支持。ERC中心的赠款为IRB提供了资金。

本研究是在赫尔辛基宣布之后进行的，该协议得到了解决方案机构审查委员会的批准（IRB，2021/09/14）。该研究遵循了《赫尔辛基宣言》的报告准则。所有参与者都对调查表提供了知情同意。该调查完全 通过 互联网在线进行。如果参与者符合资格要求，则同意书，研究项目传单和OSDI问卷将通过电子邮件发送给他们。在提交同意书并完成OSDI问卷后，在线发行了一张10美元的礼品信用卡，用于...

<ol>
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K., Veral, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+effect+of+continuous+positive+airway+pressure+treatment+for+obstructive+sleep+apnea+syndrome+on+the+ocular+surface.">The effect of continuous positive airway pressure treatment for obstructive sleep apnea syndrome on the ocular surface.</a> Cornea. 31 (6), 604-608 (2012).</li><li>Giannaccare, G., Vaccaro, S., Mancini, A., Scorcia, V. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dry+eye+in+the+COVID-19+era:+how+the+measures+for+controlling+pandemic+might+harm+ocular+surface.">Dry eye in the COVID-19 era: how the measures for controlling pandemic might harm ocular surface.</a> Graefe's Archive for Clinical and Experimental Ophthalmology. 258 (11), 2567-2568 (2020).</li><li>Uchino, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Prevalence+of+dry+eye+disease+and+its+risk+factors+in+visual+display+terminal+users:+the+Osaka+study.">Prevalence of dry eye disease and its risk factors in visual display terminal users: the Osaka study.</a> American Journal of Ophthalmology. 156 (4), 759-766 (2013).</li><li>Inomata, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Characteristics+and+risk+factors+associated+with+diagnosed+and+undiagnosed+symptomatic+dry+eye+using+a+smartphone+application.">Characteristics and risk factors associated with diagnosed and undiagnosed symptomatic dry eye using a smartphone application.</a> JAMA Ophthalmology. 138 (1), 58-68 (2020).</li><li>Schiffman, R. 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之前的几项研究已经报告了DES使用Schirmer测试，撕裂分手时间（TBUT）和OSDI评分12。本研究使用AOS软件通过边缘发红来确定DES。一个重要的关键协议步骤是拥有清晰的眼睛图像;如果图像模糊，确定边缘发红是非常具有挑战性的，并且很可能无法获得准确的读数。收集完所有图像后，故障排除技术之一是检查图像的清晰度。软件限制之一是，如果图像模糊，读数将不准确，并且在这...

2019年12月，在中国武汉发现了由SARS-COV-2病毒感染引起的COVID-19。Meduri等人1报告 称，COVID-19患者轻度眼部症状的患病率很高。在意大利，由于大流行2，眼科手术程序有所减少。自疫情爆发以来，许多人一直在家工作并戴口罩作为预防措施。这些元素中的每一个以及数字设备和在线学习3 的使用分别导致了干眼综合症（DES）和眼睛疲劳3，4。此外，有证据表明戴口罩会导致DES。佩戴口罩可能导致泪液蒸发和结膜不适5.Giannaccare等人报告说，10.3%的人在大流行期间有上升的眼部不适症状，OSDI的平均得分为21分，平均年龄为28.5岁6岁。
日本的一项横断面研究报告称，日本女性患有明确或可能的干眼病合并结果的比例为76.5%，高于使用Visual Display Terminal7的男性办公室员工的比例。根据Inomata等人的说法，与少于4小时/天的8小时相比，长时间的屏幕暴露超过8小时/天与有症状的干眼症有关。OSDI已被证明是评估DES9，10严重程度的有效和可靠的调查问卷。AOS软件已经用于确定结膜充血，并且它已被证明是非常有效的软件11。
本研究调查了DES在20-45岁健康人群中的常见程度。从2021年10月31日至2021年12月1日，对40人进行了眼表疾病指数（OSDI）问卷调查，以进行测试。AOS和OSDI调查用于评估DES。最后，比较了两种分级方法：OSDI评分和AOS软件。参与者必须首先填写一份资格调查问卷，其中包括以下纳入标准：（1）健康个体;（2）年龄在20-45岁之间;（3）参与者必须位于美国。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>AOS SOFTWARE</td>
			<td>Advanced Ophthalmic Systems</td>
			<td>SPARCA</td>
			<td>software to access limbal redness</td>
		</tr>
		<tr>
			<td>Microsoft excel</td>
			<td>Microsoft</td>
			<td></td>
			<td>for data collection and analysis</td>
		</tr>
	</tbody>
</table>

comparing objective conjunctival hyperemia grading and the ocular surface disease index score in dry eye syndrome during covid-19

由于在大流行期间戴口罩，使用数字设备和远程工作，干眼症（DES）的发病率有所增加。在COVID-19大流行期间进行了一项调查，以确定干眼症的患病率。一项横断面研究调查了美国 20-45 岁健康患者在 COVID-19 期间 DES 的流行程度。从2021年10月31日至2021年12月1日，对40名个体进行了眼表疾病指数（OSDI）问卷调查。AOS和OSDI调查用于评估DES。受试者平均年龄为29岁（SD 14.14），其中男性23人（57.5%），女性17人（42.5%）。根据OSDI调查，低DES，中度DES和重度DES的患病率分别为15%，77.5%和7.5%。白人（W）代表人口的50%，而非裔美国人（AA）占35%，亚洲人占7.5%，西班牙裔占7.5%。轻度DES影响了77.5%的受试者，其中64.50%为男性，35.50%为女性。根据AOS客观分级系统，轻度（M）DES，中度（MO）DES和重度（S）DES的患病率分别为40%，12.5%和15%。使用线性回归来比较两个分级系统，并证明了两个分级系统之间的强关系。

受试者平均年龄为29岁（平均±SD，29±14.14），其中23名男性（57.5%）和17名女性（42.5%）（表2）。白人占人口的50%，而非裔美国人占35%，亚洲人占7.5%，西班牙裔占7.5%（图2）。OSDI的平均调查得分为6.17±6.24，37.94±5.07，46±0（低，中，高）（图3）。根据OSDI调查，低DES，中度DES和重度DES的患病率分别为15%，77.5%和7.5%（图4?...

Watch this Scientific Journal Video about Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19 at JoVE.com

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

本方案描述了对40名年龄在20至45岁之间的健康受试者进行的横断面研究，以评估COVID-19期间干眼综合征（DES）的患病率。OSDI调查评估了DES，并使用先进的眼科系统（AOS）软件来评估边缘发红。

COVID-19期间干眼症患者结膜充血分级与眼表疾病指数评分的比较

The incidence of dry eye syndrome (DES) has increased due to wearing masks, utilizing digital devices, and working remotely during the pandemic. A survey ...

目前，虽然OSDI调查通常用于评估干眼综合症，但AOS软件将使用发红分级系统客观地确定干眼综合症。使用AOS软件的主要优点是客观地评估干眼综合症。为了调查干眼症或DES的患病率，请通过电子邮件将眼表疾病指数或OSDI问卷发送给参与者，并征得知情同意。根据对问卷的回答，对参与者进行评分。根据 OSDI 评分，将患者分为低、中和高类别。对于高级眼科系统或AOS软件的DES评估，首先，拍摄受试者的眼睛，一次一只眼睛，并分配受试者ID号，并保存受试者 ID.To 添加受试者，单击“添加”选项卡。然后，填写“标题”选项卡。接下来，填写名字，姓氏，出生日期和电子邮件地址，并确认电子邮件地址。然后，填写国家卫生服务ID和医疗记录号码。接下来，填写“注释”选项卡，然后单击“保存”。现在，选择主题 ID。然后单击“添加/查看图像”。然后点击加添加。要将图像上传到AOS进行边缘发红评估，首先，单击“新检查”选项卡，然后单击“图像加号”选项卡，然后添加右眼图像。单击“所选媒体”选项卡。之后，单击“球茎”图标，然后单击“面积”选项卡，然后单击“分析延髓发红分级等级”，从 0 到 4。对于图像分析，首先，单击从靠近瞳孔边缘的边缘区域开始的图像，然后按照模式覆盖边缘区域。然后，单击“保存分析”。接下来，单击发红地图。并保存分析。最后，单击“生成报告”。要生成PDF，请单击两个图像，然后类似地添加左眼图像。对于使用AOS软件对边缘发红进行分级，使用经过验证的客观分级软件分析延髓结膜发红的图像，使用结膜边缘区域的延髓发红功能，使用0.1单位的0到4的自动连续分级。对于数据分析，首先，创建一个 Microsoft Excel 表，汇总受试者 ID、年龄、性别、种族、OSDI 分数和边缘发红。然后使用 Excel 计算年龄、OSDI 评分和边缘发红评分，以及它们的均值和标准差。要计算 DES 患病率低的百分比，请将 DES 低的受试者数量除以受试者总数，然后乘以 100。同样，计算中度和重度 DES 的患病率百分比。若要确定 OSDI 和 AOS 红度分数之间的关系，请在 Excel 中使用两个值的平均值以及两个平均值之间的差值执行线性回归分析。还要确定 P 值。在这项研究中，从OSDI问卷中获得的分数用于表征调查的参与者。调查显示，低DES、中度DES和重度DES的患病率分别为15%、77.5%和7.5%。AOS软件用于参与者的渐变，根据他们眼睛的发红程度。AOS客观分级系统显示，轻度DES、中度DES和重度DES的患病率分别为27.5%、12.5%和10%。线性回归分析表明，这两种渐变系统彼此之间具有很强的关系。确保拍摄对象拍摄的图像清晰且重点突出。否则，AOS软件将无法为您提供准确的数据。在使用AOS体重软件确定干眼综合症后，我们可以将结果与OSDI调查进行比较，OSDI调查被认为是评估干眼综合症的金标准。AOS软件可以客观地评估患者的干眼综合征。

Research

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Customizing a Cryolite Glass Prosthetic Eye

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