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DOI :
10.3791/63949-v
August 8th, 2022
Chapters
0:04
Introduction
0:35
Evaluation of the Cardiac Morphology and Function
1:54
Results: Validating the Pathogenicity of G823E Mutation Using the C57BL/6N Murine Model
3:17
Conclusion
임상 연구에서 발견된 가족성 유전성 심근병증 계열을 기반으로 이 돌연변이를 확인하기 위해 CRISPR/Cas9 매개 게놈 엔지니어링을 통해 마우스 MYH7 유전자좌에서 점 돌연변이(G823E)가 있는 C57BL/6N 마우스 모델을 만들었습니다.
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