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DOI :
10.3791/64050-v
June 23rd, 2022
Chapters
0:04
Introduction
0:41
Peptide Mapping Procedure
2:38
Millisecond Hydrogen/Deuterium Exchange Study
5:34
Data Processing and Data Analysis
7:19
Results: Measuring the Conformational Dynamics of aSyn
8:14
Conclusion
单体α-突触核蛋白的结构集合影响其生理功能和理化性质。本方案描述了如何进行毫秒氢/氘交换质谱和随后的数据分析,以确定在生理条件下这种内在无序蛋白质的单体的构象信息。
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