Hipertermia gerada por ultrassom focalizado de alta intensidade guiado por ressonância magnética: um método de tratamento viável em um modelo de rabdomiossarcoma murino
January 13th, 2023
•Claire Wunker1,2, Karolina Piorkowska3, Ben Keunen3, Yael Babichev2, Suzanne M. Wong3,4, Maximilian Regenold5, Michael Dunne5, Julia Nomikos1,2, Maryam Siddiqui6, Samuel Pichardo6, Warren Foltz7, Adam C. Waspe3,8, Justin T. Gerstle3,9, James M. Drake1,3,4,10, Rebecca A. Gladdy1,2,10
1Institute of Medical Science, University of Toronto, 2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 3The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, 4Institute of Biomedical Engineering, University of Toronto, 5Leslie Dan Faculty of Pharmacy, University of Toronto, 6Departments of Radiology and Clinical Neurosciences, University of Calgary, 7Department of Radiation Oncology, University of Toronto, 8Department of Medical Imaging, University of Toronto, 9Department of Pediatric Surgery, University of Toronto, 10Department of Surgery, University of Toronto
Apresentamos aqui um protocolo para usar hipertermia controlada, gerada por ultrassom focalizado de alta intensidade guiado por ressonância magnética, para desencadear a liberação de drogas de lipossomas sensíveis à temperatura em um modelo de rabdomiossarcoma em camundongos.
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