Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

DOI :

10.3791/64544-v

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January 13th, 2023

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1,899 Views

Claire Wunker^1,2, Karolina Piorkowska³, Ben Keunen³, Yael Babichev², Suzanne M. Wong^3,4, Maximilian Regenold⁵, Michael Dunne⁵, Julia Nomikos^1,2, Maryam Siddiqui⁶, Samuel Pichardo⁶, Warren Foltz⁷, Adam C. Waspe^3,8, Justin T. Gerstle^3,9, James M. Drake^1,3,4,10, Rebecca A. Gladdy^1,2,10

¹Institute of Medical Science, University of Toronto, ²Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, ³The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, ⁴Institute of Biomedical Engineering, University of Toronto, ⁵Leslie Dan Faculty of Pharmacy, University of Toronto, ⁶Departments of Radiology and Clinical Neurosciences, University of Calgary, ⁷Department of Radiation Oncology, University of Toronto, ⁸Department of Medical Imaging, University of Toronto, ⁹Department of Pediatric Surgery, University of Toronto, ¹⁰Department of Surgery, University of Toronto

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Presented here is a protocol to use controlled hyperthermia, generated by magnetic resonance-guided high intensity focused ultrasound, to trigger drug release from temperature-sensitive liposomes in a rhabdomyosarcoma mouse model.

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