Institute of Medical Science,
Department of Surgery
Rebecca A. Gladdy has not added Biography.
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The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice.
Cancer cell Jan, 2003 | Pubmed ID: 12559174
ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes.
Blood Mar, 2007 | Pubmed ID: 17077325
Plk4 is required for cytokinesis and maintenance of chromosomal stability.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2010 | Pubmed ID: 20348415
Desmoid-type fibromatosis and pregnancy: a multi-institutional analysis of recurrence and obstetric risk.
Annals of surgery May, 2014 | Pubmed ID: 24477160
Development of genetically flexible mouse models of sarcoma using RCAS-TVA mediated gene delivery.
PloS one , 2014 | Pubmed ID: 24733554
Kras activation in p53-deficient myoblasts results in high-grade sarcoma formation with impaired myogenic differentiation.
Oncotarget Jun, 2015 | Pubmed ID: 25992772
PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.
Journal of translational medicine Mar, 2016 | Pubmed ID: 26952093
Toward Observation as First-line Management in Abdominal Desmoid Tumors.
Annals of surgical oncology Jul, 2016 | Pubmed ID: 27020588
Presacral Myelolipoma: Diagnosis on Imaging With Pathologic and Clinical Correlation.
AJR. American journal of roentgenology Sep, 2016 | Pubmed ID: 27248571
Results of Resection for Recurrent or Residual Retroperitoneal Sarcoma After Failed Primary Treatment.
Annals of surgical oncology Jan, 2017 | Pubmed ID: 27554502
Retroperitoneal Sarcoma: Fact, Opinion, and Controversy.
Surgical oncology clinics of North America Oct, 2016 | Pubmed ID: 27591493
Clinical outcomes in breast angiosarcoma patients: A rare tumor with unique challenges.
Journal of surgical oncology Dec, 2017 | Pubmed ID: 29205355
Prognostic models for RPS patients-Attempting to predict patient outcomes.
Journal of surgical oncology Jan, 2018 | Pubmed ID: 29266220
Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma.
Oncogene May, 2018 | Pubmed ID: 29487419
Risk-stratified surveillance in dermatofibrosarcoma protuberans: Less is more.
Cancer Mar, 2019 | Pubmed ID: 30644529
Comparison of published risk models for prediction of outcome in patients with extrameningeal solitary fibrous tumour.
Histopathology Nov, 2019 | Pubmed ID: 31206727
Clinical benefit of methotrexate plus vinorelbine chemotherapy for desmoid fibromatosis (DF) and correlation of treatment response with MRI.
Cancer medicine Sep, 2019 | Pubmed ID: 31301110
Early and Late Complications of Percutaneous Core Needle Biopsy of Retroperitoneal Tumors at Two Tertiary Sarcoma Centers.
Annals of surgical oncology Dec, 2019 | Pubmed ID: 31372868
If Active Surveillance is the Standard of Care for Desmoid Patients, When Should Intervention be Considered?
Annals of surgical oncology Dec, 2019 | Pubmed ID: 31552615
Virtual Biobanking for Retroperitoneal Sarcoma: A Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) Initiative.
Annals of surgical oncology Oct, 2020 | Pubmed ID: 32591952
Abdominal neoplastic manifestations of neurofibromatosis type 1.
Neuro-oncology advances Jul, 2020 | Pubmed ID: 32642738
Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG.
Cancer Nov, 2020 | Pubmed ID: 32797703
Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years.
Annals of surgical oncology Mar, 2021 | Pubmed ID: 33073340
Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: An Updated Consensus Approach from the Transatlantic Australasian RPS Working Group.
Annals of surgical oncology Nov, 2021 | Pubmed ID: 33852100
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.
Nature communications Jul, 2021 | Pubmed ID: 34301934
ASO Author Reflections: Rethinking Radiation Associated Angiosarcoma of the Breast-Secondary Malignancies That Require Expert Care for Improved Outcomes.
Annals of surgical oncology Jan, 2022 | Pubmed ID: 34403005
Multidisciplinary Intervention in Radiation-Associated Angiosarcoma of the Breast: Patterns of Recurrence and Response to Treatment.
Annals of surgical oncology Jan, 2022 | Pubmed ID: 34409543
Longitudinal prognostication in retroperitoneal sarcoma survivors: Development and external validation of two dynamic nomograms.
European journal of cancer (Oxford, England : 1990) Nov, 2021 | Pubmed ID: 34555648
Effect of Preoperative Treatment on the Performance of Predictive Nomograms in Primary Retroperitoneal Sarcoma.
Annals of surgical oncology Apr, 2022 | Pubmed ID: 35022902
Correction to: Effect of Preoperative Treatment on the Performance of Predictive Nomograms in Primary Retroperitoneal Sarcoma.
Annals of surgical oncology Jun, 2022 | Pubmed ID: 35072866
Leiomyosarcoma: Current Clinical Management and Future Horizons.
Surgical oncology clinics of North America Jul, 2022 | Pubmed ID: 35715148
Management of Locally Recurrent Retroperitoneal Sarcoma in the Adult: An Updated Consensus Approach from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group.
Annals of surgical oncology Nov, 2022 | Pubmed ID: 35767103
Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Annals of surgery Jul, 2022 | Pubmed ID: 35833413
Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments.
Cancer treatment reviews Nov, 2022 | Pubmed ID: 36031697
Evidence for the Current Management of Soft-tissue Sarcoma and Gastrointestinal Stromal Tumors and Emerging Directions.
Surgical oncology clinics of North America Jan, 2023 | Pubmed ID: 36410916
Claire Wunker1,2,
Karolina Piorkowska3,
Ben Keunen3,
Yael Babichev2,
Suzanne M. Wong3,4,
Maximilian Regenold5,
Michael Dunne5,
Julia Nomikos1,2,
Maryam Siddiqui6,
Samuel Pichardo6,
Warren Foltz7,
Adam C. Waspe3,8,
Justin T. Gerstle3,9,
James M. Drake1,3,4,10,
Rebecca A. Gladdy1,2,10
1Institute of Medical Science, University of Toronto,
2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital,
3The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children,
4Institute of Biomedical Engineering, University of Toronto,
5Leslie Dan Faculty of Pharmacy, University of Toronto,
6Departments of Radiology and Clinical Neurosciences, University of Calgary,
7Department of Radiation Oncology, University of Toronto,
8Department of Medical Imaging, University of Toronto,
9Department of Pediatric Surgery, University of Toronto,
10Department of Surgery, University of Toronto
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