Spontan murin model af anaplastisk kræft i skjoldbruskkirtlen
February 3rd, 2023
•Huayun Yan1, Yingfang Ma1, Xinyue Zhou2, Yushuang He3, Yang Liu2, Carlos Caulin4, Leiming Wang5, Heng Xu1,6, Han Luo2,6
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, 2Division of Thyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, Department of General Surgery, West China Hospital, Sichuan University, 3Department of Ultrasound, West China Hospital of Sichuan University, Sichuan University, 4Department of Otolaryngology-Head & Neck Surgery and University of Arizona Cancer Center, University of Arizona, 5Center for Translational Medicine, Shenzhen Bay Laboratory, 6Division of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University
Her præsenterer vi en standard pipeline til opnåelse af murine ATC-tumorer ved spontane genetisk manipulerede musemodeller. Endvidere præsenterer vi tumordynamik og patologisk information om de primære og metastaserede læsioner. Denne model vil hjælpe forskere med at forstå tumorigenese og lette lægemiddelopdagelser.
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