Modelo Murino Espontâneo de Câncer Anaplásico de Tireoide
February 3rd, 2023
•Huayun Yan1, Yingfang Ma1, Xinyue Zhou2, Yushuang He3, Yang Liu2, Carlos Caulin4, Leiming Wang5, Heng Xu1,6, Han Luo2,6
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, 2Division of Thyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, Department of General Surgery, West China Hospital, Sichuan University, 3Department of Ultrasound, West China Hospital of Sichuan University, Sichuan University, 4Department of Otolaryngology-Head & Neck Surgery and University of Arizona Cancer Center, University of Arizona, 5Center for Translational Medicine, Shenzhen Bay Laboratory, 6Division of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University
Aqui, apresentamos um pipeline padrão para a obtenção de tumores ATC murinos por modelos espontâneos de camundongos geneticamente modificados. Além disso, apresentamos a dinâmica tumoral e informações patológicas sobre as lesões primárias e metastizadas. Esse modelo ajudará os pesquisadores a entender a tumorigênese e facilitará a descoberta de drogas.
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