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Please note that all translations are automatically generated. Click here for the English version.
1.2K Views
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01:28 min
February 16th, 2024
DOI :
10.3791/66486-v
Transcript
我们成功开发了一种人类阴道芯片,该芯片支持鳞状分层阴道上皮的自发分化,形成强大的屏障,对激素做出反应,并产生支持氧梯度的微生物组。2D 和类器官培养目前用于研究阴道菌群失调,但由于其静态性质,它们无法模拟阴道微环境的生理复杂性。动物模型也无法模拟人类月经周期中存在的相同荷尔蒙变化,并且动物物种和人类的阴道微生物组不同。
我们着手探索器官芯片技术是否可用于开发人类阴道微生物组相互作用的临床前模型,该模型可能用于发现和评估基于微生物组的潜在疗法。阴道芯片允许流体动态流过阴道上皮和基
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