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DOI :
10.3791/786-v
•
19:50 min
July 16th, 2008
Chapters
0:05
Introduction
0:21
Protein folding problem
2:07
Diseases caused by problems of protein folding
3:33
Mechanism of prion diseases
6:47
Protein as a genetic material
8:08
Yeast as a model organism to investigate neurodegenerative diseases
11:25
High-throughput screening in yeast
13:15
Genetic studies in model organisms
15:38
High-throughput chemical screens
18:43
Concluding remarks
在这次采访中,林德基斯特博士介绍了蛋白质折叠的朊病毒疾病,神经退行性疾病之间的关系。蛋白质折叠问题是现代生物学的核心。除了其传统的生化功能,可以进行调解的蛋白质生物信息的传输,因此可以被认为是遗传物质。最近发现的这种蛋白质的功能已为人类疾病的研究具有重要意义。林德基斯特博士还介绍了目前的实验方法,探讨基于模式生物的基因研究神经退行性疾病的机制。
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