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DOI :
10.3791/791-v
May 29th, 2008
Chapters
0:05
Introduction
0:45
What is your conceptual approach?
1:29
Mechanisms of action
2:38
Identifying a target site
3:04
Principles of molecular evolution
4:27
Mutation and selection
6:06
Defining a "new" recombinase?
6:45
Dynamics of the evolutionary process
8:11
Potential limitations
8:54
Functional stability of the Tre recombinase
9:23
Steps towards therapeutic use
10:27
Molecular medicine
在这里,我们报告TRE重组,通过定向,分子进化的一代。 TRE重组确认的HIV - 1病毒DNA的LTR序列内的一个预先定义的目标序列,切除和消灭前病毒从被感染的人体细胞。尽管还处于起步阶段,定向分子进化将允许创建自定义的酶,将作为分子的外科手术和分子医学工具。
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