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DOI :
10.3791/793-v
June 16th, 2008
Chapters
0:59
What are limitations of today's antiretroviral therapies
0:07
Title
1:41
Excision of proviral DNA. Targeting LTR specific sequences.
3:39
Addressing the problem of multiple HIV isolates.
4:35
Generation of site-specific Tre recombinase via directed molecular evolution.
5:49
Delivery of Tre recombinase, HIV-1 proviral DNA excision, and elimination of HIV-1 viruses.
6:39
Open questions.
8:21
Towards a clinical application.
現在のHIV - 1の戦略は、ウイルスのライフサイクルを抑制する働きが効果的に感染を根絶することはありません。ここで、我々は人工リコンビナーゼは、感染細胞のゲノムから効率的に切り出す統合されたHIV - 1プロウイルスDNAができることを示している。
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