Name: morris water maze experiment
Uploaded: 2008-09-24T00:00:00
Description: Watch this Scientific Journal Video about Morris Water Maze Experiment at JoVE.com

JLN werd ondersteund door MH 68347.

Het opzetten van het water maze <ol><li> De belangrijkste component van het water maze opgezet moet een rond zwembad te zijn, ongeveer 6 meter in diameter en ongeveer 3 meter diep. Als u het opnemen van de taak met een videocamera, zorg ervoor dat alle zijden van het doolhof zijn binnen het gezichtsveld van de camera&#39;s te bekijken. </li><li> Vul het water doolhof met kraanwater, dat moet bijna 26 worden ° C. Dit kan enkele uren duren, dus moet goed worden gedaan op voorhand. Controleer regelmatig de temperatuur va...

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	<li>de Bruin, J. P., Swinkels, W. A., de Brabander, J. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Response+learning+of+rats+in+a+Morris+water+maze:+involvement+of+the+medial+prefrontal+cortex.">Response learning of rats in a Morris water maze: involvement of the medial prefrontal cortex.</a> Behav. Brain Res. 85, 47-55 (1997).</li><li>Redish, A. D., Touretzky, D. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+role+of+the+hippocampus+in+solving+the+Morris+water+maze.">The role of the hippocampus in solving the Morris water maze.</a> Neural. Comput. 1, 73-111 (1998).</li><li>D'Hooge, R., De Deyn, P. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Applications+of+the+Morris+water+maze+in+the+study+of+learning+and+memory.">Applications of the Morris water maze in the study of learning and memory.</a> Brain Res. Rev. 36, 60-90 (2001).</li><li>Kallai, J., Makany, T., Karadi, K., Jacobs, W. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Spatial+orientation+strategies+in+Morris-type+virtual+water+task+for+humans.">Spatial orientation strategies in Morris-type virtual water task for humans.</a> Behav. Brain Res. 159, 187-196 (2005).</li><li>Morris, R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Developments+of+a+water-maze+procedure+for+studying+spatial+learning+in+the+rat.">Developments of a water-maze procedure for studying spatial learning in the rat.</a> J. Neurosci. Methods. 11, 47-60 (1984).</li><li>Brandeis, R., Brandys, Y., Yehuda, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+use+of+the+Morris+Water+Maze+in+the+study+of+learning+and+memory.">The use of the Morris Water Maze in the study of learning and memory.</a> Int. J. Neurosci. 48, 26-69 (1989).</li><li>Kesner, R. P., Exans, R. B., Hunt, M. 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Neurosci. 98, 946-954 (1984).</li><li>Hodges, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Maze+procedures:+the+radial-arm+and+water+maze+compared.">Maze procedures: the radial-arm and water maze compared.</a> Cogn. Brain Res. 3, 167-181 (1996).</li><li>Shumake, J., Gonzalez-Lima, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Brain+systems+underlying+susceptibility+to+helplessness+and+depression.">Brain systems underlying susceptibility to helplessness and depression.</a> Behav. Cogn. Neurosci. Rev. 2, 198-221 (2003).</li><li>Owen, J. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Physiology+of+the+menstrual+cycle.">Physiology of the menstrual cycle.</a> Am. J. Clin. 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Het water maze taak werd ontwikkeld door Morris 5. Deze taak kan worden aangepast op verschillende manieren te onderzoeken werkgeheugen, referentie-geheugen en de taak van de strategie 6. De hier beschreven procedure bevat twee kritische variabelen die een afwijking van de andere versies van het water maze vertegenwoordigen: vooropleiding, en testen op een enkele dag. Pretraining - de hippocampus is betrokken bij de ruimtelijke / relationele geheugen 7-8. Het water maze test specifie...

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<td>SMART System</td>
<td>San Diego Instruments</td>
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<td>This system is not a requirement &#x2013; there are many other behavioral systems on the market.</td>
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morris water maze experiment

De Morris water maze wordt op grote schaal gebruikt voor het ruimtelijk geheugen en het leren studeren. Dieren zijn geplaatst in een plas water die gekleurd is ondoorzichtig met poedersuiker niet-vette melk of niet-giftige tempera verf, waar ze moeten zwemmen naar een verborgen ontsnappen platform. Omdat ze in ondoorzichtige water, kunnen de dieren niet zien van het platform, en niet kan beroepen op geur om de vluchtweg te vinden. In plaats daarvan moeten ze een beroep op externe / extra-doolhof cues. Als de dieren meer vertrouwd raken met de taak, zijn ze in staat om het platform vinden sneller. Ontwikkeld door Richard G. Morris in 1984, is dit paradigma uitgegroeid tot een van de &quot;gouden standaard&quot; van Behavioral Neuroscience.

Watch this Scientific Journal Video about Morris Water Maze Experiment at JoVE.com

Morris Water Maze Experiment

De Morris water maze is een goed geaccepteerd instrument dat wordt gebruikt om de betrokkenheid van de hippocampus in een gedrags-taak document.

The Morris water maze is widely used to study spatial memory and learning. Animals are placed in a pool of water that is colored opaque with powdered ...

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