comparing-frequency-effect-between-lexical-decision-naming-tasks

Comparing the Frequency Effect Between the Lexical Decision and Naming Tasks in Chinese

In psycholinguistic research, the frequency effect can be one of the indicators for eligible experimental tasks that examine the nature of lexical access. ...

National Taiwan University

We investigated the effects of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statin) on the inhibitory effects of an angiotensin II type-1 receptor (AT1) blocker on atherosclerosis and explored cellular mechanisms. We gave apolipoprotein E null mice a high-cholesterol diet for 10 weeks and measured atherosclerotic plaque area and lipid deposition. Neither 1 mg/kg per day of valsartan nor 3 mg/kg per day of fluvastatin had any effect on blood pressure or cholesterol concentration; however, both drugs decreased plaque area and lipid deposition after 10 weeks. We then reduced the doses of both drugs to 0.1 mg/kg per day and 1 mg/kg per day, respectively. At these doses, neither drug had an effect on atherosclerotic lesions. When both drugs were combined at these doses, a significant reduction in atherosclerotic lesions was observed. Similar inhibitory effects of valsartan or fluvastatin on the expressions of nicotinamide-adenine dinucleotide/nicotinamide-adenine dinucleotide phosphate oxidase subunits p22phox and p47phox, production of superoxide anion, the expression of monocyte chemoattractant protein-1, and intercellular adhesion molecule-1 expression were observed. These results suggest that concomitant AT1 receptor and cholesterol biosynthesis blockade, particularly when given concomitantly, blunts oxidative stress and inflammation independent of blood pressure or cholesterol-related effects.

Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.

Eplerenone, a mineralocorticoid receptor antagonist, is reported to be effective to prevent end-stage cardiovascular damage induced by aldosterone. However, the effect of eplerenone on brain damage is not fully understood. Here, we investigated whether pretreatment with eplerenone attenuates stroke size in mice subjected to middle cerebral artery occlusion. Middle cerebral artery occlusion with a microfilament technique induced focal ischemia, to approximately 25% of the total area in a coronal section of the brain. Treatment with eplerenone at a dose of 1.67 mg/g chow significantly reduced the ischemic area, ischemic volume, and neurological deficit, without a blood pressure-lowering effect. Laser-Doppler flowmetry analysis showed a decrease in surface cerebral blood flow in the peripheral region after 1 h of middle cerebral artery occlusion. This decrease was smaller in mice treated with eplerenone. Superoxide production evaluated by staining with dihydroethidium was attenuated in the ischemic area of the brain in eplerenone-treated mice. Taken together, our findings suggest that eplerenone has a protective effect on ischemic brain damage, at least partly due to improvement of cerebral blood flow in the penumbra and reduction of oxidative stress.

Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model.

To investigate the expression of TGF-beta receptors in CD8+ T cells of oral lichen planus (OLP).

[Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus].

To explore the effects and related mechanism of nifedipine on vascular inflammation induced by cuff placement.

[Nifedipine attenuates vascular inflammation via inhibin NF-κB activity].

Interfacial interactions involved in reverse osmosis (RO) membrane fouling by humic acid were quantitatively evaluated using the XDLVO (extended Derjaguin-Landau-Verwey-Overbeek) approach. The role of each individual interfacial interaction during membrane fouling was elucidated with special emphasis devoted into the influence of Ca2+ under different solution pHs. The results showed that, regardless of the presence of Ca2+, van der Waals interaction favoring fouling contributed the most to the interfacial interactions at pH 3, whereas the polar interaction inhibiting fouling played a dominant role at pH 7 and pH 10. Electrostatic double layer interaction appeared to be the weakest in all cases, thus contributing the least to membrane fouling. It was the changing of polar interaction that gave rise to the influence of Ca2+ on membrane fouling, which turned out to be more significant at lower pH. Ca2+ would accelerate humic acid RO membrane fouling at most cases. Correlation analysis between interfacial free energy and fouling extent revealed that XDLVO approach could reasonably predict humic acid RO membrane fouling behaviors under different solution conditions.

[Reverse osmosis membrane fouling by humic acid using XDLVO approach: effect of calcium ions].

The extended Derjaguin-Laudau-Verwey-Overbeek (XDLVO) theory was utilized to quantitatively evaluate short-range interfacial interactions involved in microfiltration (MF) membrane fouling by sodium alginate (SA) at various ionic compositions. Results showed that for hydrophilic membrane surfaces, van der Waals interactions facilitated fouling, whereas acid-base interactions alleviated fouling; for hydrophobic membrane surfaces, however, van der Waals interactions mitigated fouling and acid-base interactions turned out to be favorable for fouling. Electrostatic double layer interactions contributed minimally to fouling when SA molecules came into contact with MF membrane surface. Ionic strength and Ca2+ affected SA fouling of MF membranes mainly through alteration of acid-base interactions between membrane and SA or among SA themselves. Higher ionic strength could make acid-base interaction less repulsive or more attractive, thus aggravating SA fouling of MF membrane. Although Ca2+ accelerated flux decline significantly, Ca2+ could enhance physical cleaning efficiencies. Under all tested ionic compositions, fouling potentials (K) of initial and subsequent stages correlated well with membrane-SA interfacial free energy of adhesion and SA-SA interfacial free energy of cohesion, respectively. This implies that the XDLVO theory is applicable for description of MF membrane fouling by SA at various ionic compositions.

[Fouling behavior of sodium alginate during microfiltration at various ionic compositions: XDLVO approach].

The high-mobility group box 1 (HMGB1) protein is a DNA-binding nuclear protein, which is overexpressed in leukemia cells. Cordycepin is characterized by strong antileukemic properties and is regarded as an effective natural compound for leukemia therapy. The aim of the present study was to investigate the impact of HMGB1 knockdown and cordycepin treatment on proliferation, apoptosis, reactive oxygen species (ROS) levels and adhesion of K562 human chronic myeloid leukemia cells. The Cell Counting kit‑8 assay was used to determine the proliferation of K562 cells. The cell cycle and apoptosis of K562 cells was determined using flow cytometric analysis. In addition, a cell adhesion assay was performed. Western blotting was used to determine the protein expression of cyclooxygenase 2, Bax, receptor for advanced glycation end-products and Bcl‑2. The data collected demonstrated that HMGB1 knockdown combined with cordycepin treatment had significant anti‑proliferative and pro‑apoptotic effects. In addition, it increased the ROS levels and reduced the adhesion of K562 cells. It was also identified that HMGB1 knockdown had synergistic effects with cordycepin, which aided in accelerating apoptosis, and inhibiting proliferation and adhesion in chronic myeloid leukemia cells. These results indicated that HMGB1 may be used as a potential therapeutic target, with cordycepin having potential as an auxiliary drug. Therefore, it is suggested that HMGB1 knockdown and corycepin treatement may present a promising therapeutic strategy for leukemia.

Article	Year
Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis. Hypertension\| PubMed ID: 15452025	2004
Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model. European journal of pharmacology\| PubMed ID: 17475237	2007
[Expression of TGF-beta receptors in CD8+ T cells of oral lichen planus]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology\| PubMed ID: 18683732	2008
[Nifedipine attenuates vascular inflammation via inhibin NF-κB activity]. Zhonghua xin xue guan bing za zhi\| PubMed ID: 21215233	2010
[Reverse osmosis membrane fouling by humic acid using XDLVO approach: effect of calcium ions]. Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.]\| PubMed ID: 22946170	2012
[Fouling behavior of sodium alginate during microfiltration at various ionic compositions: XDLVO approach]. Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.]\| PubMed ID: 24946586	2014
Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line. Molecular medicine reports\| PubMed ID: 26081986	2015

Xin-Yu Gao

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