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Gem GTPase: between a ROCK and a hard place.
Current biology : CB Jul, 2002 | Pubmed ID: 12176351
Dispatch. GTPase signalling: new functions for Diaphanous-related formins.
Current biology : CB Apr, 2003 | Pubmed ID: 12725753
Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation.
The EMBO journal May, 2003 | Pubmed ID: 12727871
Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells.
Molecular biology of the cell Jul, 2003 | Pubmed ID: 12857854
Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway.
Current biology : CB Dec, 2003 | Pubmed ID: 14680635
Rac transformation: the actin connection.
Cancer biology & therapy Jan, 2004 | Pubmed ID: 14726705
Contraction reaction: mechanical regulation of Rho GTPase.
Trends in cell biology Mar, 2004 | Pubmed ID: 15055199
RAS and RHO GTPases in G1-phase cell-cycle regulation.
Nature reviews. Molecular cell biology May, 2004 | Pubmed ID: 15122349
SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant.
Cancer research Aug, 2004 | Pubmed ID: 15313890
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis.
Cancer research Dec, 2004 | Pubmed ID: 15604264
Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
The Journal of cell biology Jan, 2005 | Pubmed ID: 15657395
Targeting Ras and Rho GTPases as opportunities for cancer therapeutics.
Current opinion in genetics & development Feb, 2005 | Pubmed ID: 15661535
Modeling human cancer: report on the Eighth Beatson International Cancer Conference.
Cancer research Dec, 2005 | Pubmed ID: 16357126
AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.
Molecular and cellular biology Feb, 2006 | Pubmed ID: 16449658
Purification of TAT-C3 exoenzyme.
Methods in enzymology , 2006 | Pubmed ID: 16472655
Conditional regulation of a ROCK-estrogen receptor fusion protein.
Methods in enzymology , 2006 | Pubmed ID: 16472686
The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.
Molecular and cellular biology Jun, 2006 | Pubmed ID: 16738326
LIM kinases: function, regulation and association with human disease.
Journal of molecular medicine (Berlin, Germany) Jun, 2007 | Pubmed ID: 17294230
Mechanisms of tumour cell invasion and metastasis.
Journal of molecular medicine (Berlin, Germany) Jun, 2007 | Pubmed ID: 17404698
The ras signalling pathway as a target in cancer therapy.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer , 2007 | Pubmed ID: 17607939
Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent.
Biochemical and biophysical research communications Feb, 2008 | Pubmed ID: 18078809
Applications for ROCK kinase inhibition.
Current opinion in cell biology Apr, 2008 | Pubmed ID: 18282695
The actin cytoskeleton in cancer cell motility.
Clinical & experimental metastasis , 2009 | Pubmed ID: 18498004
Regulating the conversion between rounded and elongated modes of cancer cell movement.
Cancer cell Nov, 2008 | Pubmed ID: 18977323
Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus.
Genesis (New York, N.Y. : 2000) Jul, 2009 | Pubmed ID: 19391117
Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis.
European journal of cell biology Sep, 2009 | Pubmed ID: 19515453
Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.
Cancer research Sep, 2009 | Pubmed ID: 19690147
MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability.
Molecular and cellular biology Dec, 2009 | Pubmed ID: 19822666
Dying alone: a tale of rho.
Cell stem cell Aug, 2010 | Pubmed ID: 20682437
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.
The Journal of cell biology Oct, 2010 | Pubmed ID: 20876278
Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion.
European journal of cell biology Jan, 2011 | Pubmed ID: 21074289
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.
Cell research Apr, 2011 | Pubmed ID: 21079653
Follow the leader: LIM kinases pave the way for collective tumor cell invasion.
Cell cycle (Georgetown, Tex.) Nov, 2010 | Pubmed ID: 21088476
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.
Cancer research Feb, 2011 | Pubmed ID: 21266354
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
PloS one , 2011 | Pubmed ID: 21358804
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Cancer cell Jun, 2011 | Pubmed ID: 21665151
Trailblazing LIM kinases take the lead in collective tumor cell invasion.
Bioarchitecture 1, 2011 | Pubmed ID: 21866254
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
PloS one , 2011 | Pubmed ID: 21949762
Actomyosin contractililty: force power drives tumor growth.
Cell cycle (Georgetown, Tex.) Oct, 2011 | Pubmed ID: 22067650
The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination.
Glia Mar, 2012 | Pubmed ID: 22139636
Development of a High-Throughput Screening Method for LIM Kinase 1 Using a Luciferase-Based Assay of ATP Consumption.
Journal of biomolecular screening Dec, 2011 | Pubmed ID: 22156225
Transcriptional regulation of Rho GTPase signaling.
Transcription Sep-Oct, 2011 | Pubmed ID: 22231116
Targeting Rho GTPase signaling for cancer therapy.
Future oncology (London, England) Feb, 2012 | Pubmed ID: 22335581
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