Michael F. Olson

Gem GTPase: between a ROCK and a hard place.

Dispatch. GTPase signalling: new functions for Diaphanous-related formins.

Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation.

Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells.

Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway.

Rac transformation: the actin connection.

Contraction reaction: mechanical regulation of Rho GTPase.

RAS and RHO GTPases in G1-phase cell-cycle regulation.

SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant.

Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis.

Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics.

Modeling human cancer: report on the Eighth Beatson International Cancer Conference.

AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.

Purification of TAT-C3 exoenzyme.

Conditional regulation of a ROCK-estrogen receptor fusion protein.

The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms.

LIM kinases: function, regulation and association with human disease.

Mechanisms of tumour cell invasion and metastasis.

The ras signalling pathway as a target in cancer therapy.

Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent.

Applications for ROCK kinase inhibition.

The actin cytoskeleton in cancer cell motility.

Regulating the conversion between rounded and elongated modes of cancer cell movement.

Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus.

Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis.

Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation.

MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability.

Dying alone: a tale of rho.

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion.

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival.

Follow the leader: LIM kinases pave the way for collective tumor cell invasion.

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.

K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.

Trailblazing LIM kinases take the lead in collective tumor cell invasion.

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.

Actomyosin contractililty: force power drives tumor growth.

The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination.

Development of a High-Throughput Screening Method for LIM Kinase 1 Using a Luciferase-Based Assay of ATP Consumption.

Transcriptional regulation of Rho GTPase signaling.

Targeting Rho GTPase signaling for cancer therapy.