ex-vivo-vivo-animal-models-for-mechanical-chemical-injuries-corneal

<em>Ex Vivo</em> and <em>In Vivo</em> Animal Models for Mechanical and Chemical Injuries of Corneal Epithelium

Corneal injury to the ocular surface, including chemical burn and trauma, may cause severe scarring, symblepharon, corneal limbal stem cells deficiency, ...

Chang-Gung Memorial Hospital

Chang-Gung University College of Medicine

National Yang Ming Chiao Tung University

To find clinical demographics of pterygium surgery and prevalence of conjunctival intraepithelial neoplasia (CIN) in pterygium specimen.

Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review.

To describe a case with a growing erythematous conjunctival mass in the left eye, diagnosed as conjunctival myxoma.

Clinical appearance and pathological findings of conjunctival myxoma: Case report and literature review.

To evaluate the role of Demodex infestation of the eyelids in patients with recurrent herpetic keratitis.

Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis.

The purpose of this study is to present characteristics and topographic findings of patients with corneal ectasia and symptomatic ocular demodicosis.

Clinical characteristics and topographic findings of corneal ectasia in patients with symptomatic  blepharitis.

This study analyzed the clinical features and molecular characteristics of methicillin-susceptible  (MSSA) ocular infections in Taiwan and compared them between community-associated (CA) and health-care-associated (HA) infections. We collected  ocular isolates from patients at Chang Gung Memorial Hospital between 2010 and 2017. The infections were classified as CA or HA using epidemiological criteria, and the isolates were molecularly characterized using pulsed-field gel electrophoresis, multilocus sequence typing, and Panton-Valentine leukocidin (PVL) gene detection. Antibiotic susceptibility was evaluated using disk diffusion and an E test. A total of 104 MSSA ocular isolates were identified; 46 (44.2%) were CA-MSSA and 58 (55.8%) were HA-MSSA. Compared with HA-MSSA strains, CA-MSSA strains caused a significantly higher rate of keratitis, but a lower rate of conjunctivitis. We identified 14 pulsotypes. ST 7/pulsotype BA was frequently identified in both CA-MSSA (28.3%) and HA-MSSA (37.9%) cases. PVL genes were identified in seven isolates (6.7%). Both CA-MSSA and HA-MSSA isolates were highly susceptible to vancomycin, teicoplanin, tigecycline, sulfamethoxazole-trimethoprim, and fluoroquinolones. The most common ocular manifestations were keratitis and conjunctivitis for CA-MSSA and HA-MSSA, respectively. The MSSA ocular isolates had diverse molecular characteristics; no specific genotype differentiated CA-MSSA from HA-MSSA. Both strains exhibited similar antibiotic susceptibility.

Article	Year
Clinical demographics of pterygium excision and prevalence of conjunctival intraepithelial neoplasia: a 15-year review. International ophthalmology\| PubMed ID: 32198608	2020
Clinical appearance and pathological findings of conjunctival myxoma: Case report and literature review. American journal of ophthalmology case reports\| PubMed ID: 32803020	2020
Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis. Clinical ophthalmology (Auckland, N.Z.)\| PubMed ID: 33380781	2020
Clinical characteristics and topographic findings of corneal ectasia in patients with symptomatic blepharitis. Taiwan journal of ophthalmology\| PubMed ID: 34295620	2021
Clinical Features and Molecular Characteristics of Methicillin-Susceptible Ocular Infection in Taiwan. Antibiotics (Basel, Switzerland)\| PubMed ID: 34943657	2021

Kuo Hsuan Hung

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