Budd Tucker

Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.

Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa.

Stem cells in large animal models of retinal and neurological disease.

Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation.

Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease.

Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.

Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells.

Loss of CD34 expression in aging human choriocapillaris endothelial cells.

Structural and biochemical analyses of choroidal thickness in human donor eyes.

Photoreceptor cells with profound structural deficits can support useful vision in mice.

Mechanical properties of murine and porcine ocular tissues in compression.

Stem cells for investigation and treatment of inherited retinal disease.

Is age-related macular degeneration a microvascular disease?

Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.

Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma.

ABCB5 is a limbal stem cell gene required for corneal development and repair.

The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning.

Induction of trabecular meshwork cells from induced pluripotent stem cells.

Gene therapy using stem cells.

Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq.

Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases.

Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

Stem cells as tools for studying the genetics of inherited retinal degenerations.

Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis.

Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study.

Prevascularized silicon membranes for the enhancement of transport to implanted medical devices.

Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial.

Selective accumulation of the complement membrane attack complex in aging choriocapillaris.

Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis.

North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.

Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration.

Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.

Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds.

Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.

Neuronal Differentiation of Induced Pluripotent Stem Cells on Surfactant Templated Chitosan Hydrogels.

A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids.

Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.

Monomeric C-reactive protein and inflammation in Age-related Macular Degeneration.

Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3-Associated Retinal Degeneration.

cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.

Two-photon polymerization for production of human iPSC-derived retinal cell grafts.

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.

Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.

Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium.

Preparation and evaluation of human choroid extracellular matrix scaffolds for the study of cell replacement strategies.

Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.

Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.

Generation of Xeno-Free, cGMP-Compliant Patient-Specific iPSCs from Skin Biopsy.

Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism.

Assessment of Adeno-Associated Virus Serotype Tropism in Human Retinal Explants.

CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.

Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.

Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors.

Effect of Molecular Weight and Functionality on Acrylated Poly(caprolactone) for Stereolithography and Biomedical Applications.

Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury.

Controlled drug delivery from 3D printed two-photon polymerized poly(ethylene glycol) dimethacrylate devices.

Two-Photon Polymerization as a Tool for Studying 3D Printed Topography-Induced Stem Cell Fate.

Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.

Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.

Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.

PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq.

Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.

Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments.

Wide-Field Swept-Source OCT and Angiography in X-Linked Retinoschisis.

CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in in Induced Pluripotent Stem Cells from Patients with Batten Disease.

Choriocapillaris Degeneration in Geographic Atrophy.

Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.

Development of a Molecularly Stable Gene Therapy Vector for the Treatment of -Associated X-Linked Retinitis Pigmentosa.

Development of High-Resolution Three-Dimensional-Printed Extracellular Matrix Scaffolds and Their Compatibility with Pluripotent Stem Cells and Early Retinal Cells.

Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats.

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration.

AUTOIMMUNE RETINOPATHY MIMICKING HERITABLE RETINAL DEGENERATION IN A PATIENT WITH COMMON VARIABLE IMMUNE DEFICIENCY.

Autologous cell replacement: a noninvasive AI approach to clinical release testing.

Single-Cell RNA Sequencing in Human Retinal Degeneration Reveals Distinct Glial Cell Populations.

Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.

Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.

Label-free microfluidic enrichment of photoreceptor cells.

Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis.

Retinal Tropism and Transduction of Adeno-Associated Virus Varies by Serotype and Route of Delivery (Intravitreal, Subretinal, or Suprachoroidal) in Rats.

Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells.

Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease.

Predominance of hyperopia in autosomal dominant Best vitelliform macular dystrophy.

Single-cell RNA sequencing in vision research: Insights into human retinal health and disease.

A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies.

The effect of retinal scaffold modulus on performance during surgical handling.

Human photoreceptor cells from different macular subregions have distinct transcriptional profiles.

Microfluidic processing of stem cells for autologous cell replacement.

An Unusual Presentation of CLN3-Associated Batten Disease With Classic Histopathologic and Ultrastructural Findings.

Intrafamilial Variability of Ocular Manifestations of von Hippel-Lindau Disease.

Label-free microfluidic enrichment of cancer cells from non-cancer cells in ascites.

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa.

Sensitive quantification of m.3243A>G mutational proportion in non-retinal tissues and its relationship with visual symptoms.

Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants.

Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy.

Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration.

Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration.

Retinal Capillary Hemangioma Leading to a Diagnosis of von Hippel-Lindau Disease in a Patient with Retinopathy of Prematurity.

Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats.

The Essential Role of the Choriocapillaris in Vision: Novel Insights from Imaging and Molecular Biology.

Vascular Findings in the Choriocapillaris in a Case of Radiation Retinopathy Secondary to Choroidal Melanoma.

Characterization of a novel Pde6b-deficient rat model of retinal degeneration and treatment with adeno-associated virus (AAV) gene therapy.

Transcriptomic and Chromatin Accessibility Analysis of the Human Macular and Peripheral Retinal Pigment Epithelium at the Single-Cell Level.

The Degree of Adeno-Associated Virus-Induced Retinal Inflammation Varies Based on Serotype and Route of Delivery: Intravitreal, Subretinal, or Suprachoroidal.

Automating iPSC generation to enable autologous photoreceptor cell replacement therapy.

Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report.

Photopolymerization Parameters Influence Mechanical, Microstructural, and Cell Loading Properties of Rapidly Fabricated Cell Scaffolds.

Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement.

Multimodal single-cell analysis of nonrandom heteroplasmy distribution in human retinal mitochondrial disease.

GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS.

Automated human induced pluripotent stem cell colony segmentation for use in cell culture automation applications.

CGMP Compliant Microfluidic Transfection of Induced Pluripotent Stem Cells for CRISPR-Mediated Genome Editing.

Gene Expression Within a Human Choroidal Neovascular Membrane Using Spatial Transcriptomics.

Demonstration of the pathogenicity of a common non-exomic mutation in ABCA4 using iPSC-derived retinal organoids and retrospective clinical data.

CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa.

A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease.

Influence of Substrate Stiffness on iPSC-Derived Retinal Pigmented Epithelial Cells.

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development.

Belzutifan in Individuals with von Hippel-Lindau Retinal Hemangioblastomas: Institutional Experience and Review of the Literature.

Exonic splice variant discovery using in vitro models of inherited retinal disease.

Ghost vessels in the eye: Cell free choriocapillaris domains in atrophic age-related macular degeneration.

Conditional Immortalization Using SV40 Large T Antigen and Its Effects on Induced Pluripotent Stem Cell Differentiation Toward Retinal Progenitor Cells.

Elevation of Granulocyte Colony Stimulating Factor in Human AMD Donor RPE-Choroid.

Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration.