Institute for Vision Research
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Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.
PloS one , 2011 | Pubmed ID: 21559507
Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2011 | Pubmed ID: 21825139
Stem cells in large animal models of retinal and neurological disease.
Stem cells international , 2012 | Pubmed ID: 22666270
Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation.
Stem cells translational medicine Jan, 2013 | Pubmed ID: 23283489
Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease.
Human molecular genetics Dec, 2013 | Pubmed ID: 23918662
Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
eLife Aug, 2013 | Pubmed ID: 23991284
Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells.
Tissue engineering. Part A May, 2014 | Pubmed ID: 24320879
Loss of CD34 expression in aging human choriocapillaris endothelial cells.
PloS one , 2014 | Pubmed ID: 24466138
Structural and biochemical analyses of choroidal thickness in human donor eyes.
Investigative ophthalmology & visual science Mar, 2014 | Pubmed ID: 24519422
Photoreceptor cells with profound structural deficits can support useful vision in mice.
Investigative ophthalmology & visual science Mar, 2014 | Pubmed ID: 24569582
Mechanical properties of murine and porcine ocular tissues in compression.
Experimental eye research Apr, 2014 | Pubmed ID: 24613781
Stem cells for investigation and treatment of inherited retinal disease.
Human molecular genetics Sep, 2014 | Pubmed ID: 24647603
Is age-related macular degeneration a microvascular disease?
Advances in experimental medicine and biology , 2014 | Pubmed ID: 24664709
Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.
PloS one , | Pubmed ID: 24671090
Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma.
Journal of stem cell research & therapy Jan, 2014 | Pubmed ID: 24883232
ABCB5 is a limbal stem cell gene required for corneal development and repair.
Nature Jul, 2014 | Pubmed ID: 25030174
The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning.
The American journal of pathology Nov, 2014 | Pubmed ID: 25204844
Induction of trabecular meshwork cells from induced pluripotent stem cells.
Investigative ophthalmology & visual science Oct, 2014 | Pubmed ID: 25298418
Gene therapy using stem cells.
Cold Spring Harbor perspectives in medicine Nov, 2014 | Pubmed ID: 25395375
Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE/choroid by RNA-Seq.
Experimental eye research Dec, 2014 | Pubmed ID: 25446321
Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases.
Progress in retinal and eye research Jan, 2015 | Pubmed ID: 25448922
Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.
Progress in retinal and eye research Mar, 2015 | Pubmed ID: 25486088
Stem cells as tools for studying the genetics of inherited retinal degenerations.
Cold Spring Harbor perspectives in medicine Dec, 2014 | Pubmed ID: 25502747
Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis.
Science translational medicine Jun, 2015 | Pubmed ID: 26062849
Allogenic iPSC-derived RPE cell transplants induce immune response in pigs: a pilot study.
Scientific reports Jul, 2015 | Pubmed ID: 26138532
Prevascularized silicon membranes for the enhancement of transport to implanted medical devices.
Journal of biomedical materials research. Part B, Applied biomaterials Nov, 2016 | Pubmed ID: 26316050
Using patient-specific induced pluripotent stem cells to interrogate the pathogenicity of a novel retinal pigment epithelium-specific 65 kDa cryptic splice site mutation and confirm eligibility for enrollment into a clinical gene augmentation trial.
Translational research : the journal of laboratory and clinical medicine Dec, 2015 | Pubmed ID: 26364624
Selective accumulation of the complement membrane attack complex in aging choriocapillaris.
Experimental eye research May, 2016 | Pubmed ID: 26368849
Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis.
Human molecular genetics Jan, 2016 | Pubmed ID: 26494905
North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.
Ophthalmology Jan, 2016 | Pubmed ID: 26507665
Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration.
The Journal of pathology Feb, 2016 | Pubmed ID: 26564985
Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.
Stem cells translational medicine Feb, 2016 | Pubmed ID: 26683869
Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 06, 2016 | Pubmed ID: 26692377
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.
Investigative ophthalmology & visual science Dec, 2015 | Pubmed ID: 26720480
Neuronal Differentiation of Induced Pluripotent Stem Cells on Surfactant Templated Chitosan Hydrogels.
Biomacromolecules 05, 2016 | Pubmed ID: 27008004
A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids.
Current protocols in stem cell biology May, 2016 | Pubmed ID: 27171793
Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.
Proceedings of the National Academy of Sciences of the United States of America 06, 2016 | Pubmed ID: 27274060
Monomeric C-reactive protein and inflammation in Age-related Macular Degeneration.
The Journal of pathology Jul, 2016 | Pubmed ID: 27376713
Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3-Associated Retinal Degeneration.
Human gene therapy Oct, 2016 | Pubmed ID: 27400765
cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.
Scientific reports Jul, 2016 | Pubmed ID: 27471043
Two-photon polymerization for production of human iPSC-derived retinal cell grafts.
Acta biomaterialia Jun, 2017 | Pubmed ID: 28351682
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.
Investigative ophthalmology & visual science Apr, 2017 | Pubmed ID: 28384726
Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.
Stem cell research May, 2017 | Pubmed ID: 28390992
Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium.
Stem cells translational medicine Jun, 2017 | Pubmed ID: 28474838
Preparation and evaluation of human choroid extracellular matrix scaffolds for the study of cell replacement strategies.
Acta biomaterialia Jul, 2017 | Pubmed ID: 28483697
Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.
Ophthalmology Sep, 2017 | Pubmed ID: 28559085
Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2017 | Pubmed ID: 28619647
Generation of Xeno-Free, cGMP-Compliant Patient-Specific iPSCs from Skin Biopsy.
Current protocols in stem cell biology Aug, 2017 | Pubmed ID: 28806854
Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism.
Ophthalmic genetics , 2018 | Pubmed ID: 28949775
Assessment of Adeno-Associated Virus Serotype Tropism in Human Retinal Explants.
Human gene therapy Apr, 2018 | Pubmed ID: 29160116
CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.
Current protocols in stem cell biology Feb, 2018 | Pubmed ID: 29512106
CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.
Progress in retinal and eye research Jul, 2018 | Pubmed ID: 29578069
Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.
Biology open May, 2018 | Pubmed ID: 29685994
Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors.
Eye (London, England) Nov, 2018 | Pubmed ID: 30013157
Effect of Molecular Weight and Functionality on Acrylated Poly(caprolactone) for Stereolithography and Biomedical Applications.
Biomacromolecules Sep, 2018 | Pubmed ID: 30044915
Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury.
Scientific reports Sep, 2018 | Pubmed ID: 30190604
Controlled drug delivery from 3D printed two-photon polymerized poly(ethylene glycol) dimethacrylate devices.
International journal of pharmaceutics Dec, 2018 | Pubmed ID: 30268853
Two-Photon Polymerization as a Tool for Studying 3D Printed Topography-Induced Stem Cell Fate.
Macromolecular bioscience 02, 2019 | Pubmed ID: 30430755
Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.
Translational vision science & technology Nov, 2018 | Pubmed ID: 30519502
Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.
Microvascular research May, 2019 | Pubmed ID: 30571950
Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2019 | Pubmed ID: 30622176
PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq.
Cell reports Feb, 2019 | Pubmed ID: 30759402
Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.
Genes Apr, 2019 | Pubmed ID: 30959774
Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments.
Stem cells translational medicine Aug, 2019 | Pubmed ID: 31004408
Wide-Field Swept-Source OCT and Angiography in X-Linked Retinoschisis.
Ophthalmology. Retina Feb, 2019 | Pubmed ID: 31014769
CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in in Induced Pluripotent Stem Cells from Patients with Batten Disease.
The CRISPR journal Feb, 2018 | Pubmed ID: 31021193
Choriocapillaris Degeneration in Geographic Atrophy.
The American journal of pathology Jul, 2019 | Pubmed ID: 31051169
Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.
Acta biomaterialia Aug, 2019 | Pubmed ID: 31055121
Development of a Molecularly Stable Gene Therapy Vector for the Treatment of -Associated X-Linked Retinitis Pigmentosa.
Human gene therapy Aug, 2019 | Pubmed ID: 31106594
Development of High-Resolution Three-Dimensional-Printed Extracellular Matrix Scaffolds and Their Compatibility with Pluripotent Stem Cells and Early Retinal Cells.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics , 2020 | Pubmed ID: 31414943
Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats.
Human gene therapy Nov, 2019 | Pubmed ID: 31456426
Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2019 | Pubmed ID: 31712411
AUTOIMMUNE RETINOPATHY MIMICKING HERITABLE RETINAL DEGENERATION IN A PATIENT WITH COMMON VARIABLE IMMUNE DEFICIENCY.
Retinal cases & brief reports Jan, 2022 | Pubmed ID: 31764884
Autologous cell replacement: a noninvasive AI approach to clinical release testing.
The Journal of clinical investigation Feb, 2020 | Pubmed ID: 31961338
Single-Cell RNA Sequencing in Human Retinal Degeneration Reveals Distinct Glial Cell Populations.
Cells Feb, 2020 | Pubmed ID: 32069977
Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.
Microvascular research Sep, 2020 | Pubmed ID: 32531351
Human iPSC Modeling Reveals Mutation-Specific Responses to Gene Therapy in a Genotypically Diverse Dominant Maculopathy.
American journal of human genetics Aug, 2020 | Pubmed ID: 32707085
Label-free microfluidic enrichment of photoreceptor cells.
Experimental eye research Oct, 2020 | Pubmed ID: 32771499
Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis.
Experimental eye research Nov, 2020 | Pubmed ID: 32910939
Retinal Tropism and Transduction of Adeno-Associated Virus Varies by Serotype and Route of Delivery (Intravitreal, Subretinal, or Suprachoroidal) in Rats.
Human gene therapy Dec, 2020 | Pubmed ID: 32948113
Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells.
Stem cell research & therapy Sep, 2020 | Pubmed ID: 32967716
Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease.
Progress in retinal and eye research Jul, 2021 | Pubmed ID: 33130253
Predominance of hyperopia in autosomal dominant Best vitelliform macular dystrophy.
The British journal of ophthalmology Apr, 2022 | Pubmed ID: 33243830
Single-cell RNA sequencing in vision research: Insights into human retinal health and disease.
Progress in retinal and eye research Jul, 2021 | Pubmed ID: 33383180
A Safe GDNF and GDNF/BDNF Controlled Delivery System Improves Migration in Human Retinal Pigment Epithelial Cells and Survival in Retinal Ganglion Cells: Potential Usefulness in Degenerative Retinal Pathologies.
Pharmaceuticals (Basel, Switzerland) Jan, 2021 | Pubmed ID: 33440745
The effect of retinal scaffold modulus on performance during surgical handling.
Experimental eye research Jun, 2021 | Pubmed ID: 33838142
Human photoreceptor cells from different macular subregions have distinct transcriptional profiles.
Human molecular genetics Jul, 2021 | Pubmed ID: 34014299
Microfluidic processing of stem cells for autologous cell replacement.
Stem cells translational medicine Oct, 2021 | Pubmed ID: 34156760
An Unusual Presentation of CLN3-Associated Batten Disease With Classic Histopathologic and Ultrastructural Findings.
Journal of neuropathology and experimental neurology Nov, 2021 | Pubmed ID: 34313756
Intrafamilial Variability of Ocular Manifestations of von Hippel-Lindau Disease.
Ophthalmology. Retina Jan, 2022 | Pubmed ID: 34416425
Label-free microfluidic enrichment of cancer cells from non-cancer cells in ascites.
Scientific reports Sep, 2021 | Pubmed ID: 34504124
Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa.
Gene therapy May, 2022 | Pubmed ID: 34518651
Sensitive quantification of m.3243A>G mutational proportion in non-retinal tissues and its relationship with visual symptoms.
Human molecular genetics Mar, 2022 | Pubmed ID: 34590675
Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Dec, 2021 | Pubmed ID: 34597181
Correlation of features on OCT with visual acuity and Gass lesion type in Best vitelliform macular dystrophy.
BMJ open ophthalmology , 2021 | Pubmed ID: 34993349
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration.
The Journal of pathology May, 2022 | Pubmed ID: 35038170
Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degeneration.
Human molecular genetics Jul, 2022 | Pubmed ID: 35181781
Retinal Capillary Hemangioma Leading to a Diagnosis of von Hippel-Lindau Disease in a Patient with Retinopathy of Prematurity.
Case reports in ophthalmology , 2022 | Pubmed ID: 35702652
Biocompatibility of Human Induced Pluripotent Stem Cell-Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats.
Cell transplantation , 2022 | Pubmed ID: 35758274
The Essential Role of the Choriocapillaris in Vision: Novel Insights from Imaging and Molecular Biology.
Annual review of vision science Sep, 2022 | Pubmed ID: 36108103
Vascular Findings in the Choriocapillaris in a Case of Radiation Retinopathy Secondary to Choroidal Melanoma.
Case reports in ophthalmology , 2022 | Pubmed ID: 36160486
Characterization of a novel Pde6b-deficient rat model of retinal degeneration and treatment with adeno-associated virus (AAV) gene therapy.
Gene therapy Apr, 2023 | Pubmed ID: 36175490
Transcriptomic and Chromatin Accessibility Analysis of the Human Macular and Peripheral Retinal Pigment Epithelium at the Single-Cell Level.
The American journal of pathology Nov, 2023 | Pubmed ID: 36775060
The Degree of Adeno-Associated Virus-Induced Retinal Inflammation Varies Based on Serotype and Route of Delivery: Intravitreal, Subretinal, or Suprachoroidal.
Human gene therapy Jun, 2023 | Pubmed ID: 36793189
Automating iPSC generation to enable autologous photoreceptor cell replacement therapy.
Journal of translational medicine Feb, 2023 | Pubmed ID: 36855199
Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report.
Stem cell research & therapy Mar, 2023 | Pubmed ID: 36978104
Photopolymerization Parameters Influence Mechanical, Microstructural, and Cell Loading Properties of Rapidly Fabricated Cell Scaffolds.
ACS biomaterials science & engineering May, 2023 | Pubmed ID: 37075323
Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement.
Stem cells translational medicine Jun, 2023 | Pubmed ID: 37221451
Multimodal single-cell analysis of nonrandom heteroplasmy distribution in human retinal mitochondrial disease.
JCI insight Jul, 2023 | Pubmed ID: 37289546
GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS.
bioRxiv : the preprint server for biology Jun, 2023 | Pubmed ID: 37398429
Automated human induced pluripotent stem cell colony segmentation for use in cell culture automation applications.
SLAS technology Dec, 2023 | Pubmed ID: 37454765
CGMP Compliant Microfluidic Transfection of Induced Pluripotent Stem Cells for CRISPR-Mediated Genome Editing.
Stem cells (Dayton, Ohio) Nov, 2023 | Pubmed ID: 37632456
Gene Expression Within a Human Choroidal Neovascular Membrane Using Spatial Transcriptomics.
Investigative ophthalmology & visual science Oct, 2023 | Pubmed ID: 37878301
Demonstration of the pathogenicity of a common non-exomic mutation in ABCA4 using iPSC-derived retinal organoids and retrospective clinical data.
Human molecular genetics Aug, 2024 | Pubmed ID: 37930186
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa.
The CRISPR journal Dec, 2023 | Pubmed ID: 38108516
A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease.
Ophthalmology Aug, 2024 | Pubmed ID: 38309476
Influence of Substrate Stiffness on iPSC-Derived Retinal Pigmented Epithelial Cells.
Stem cells translational medicine Jun, 2024 | Pubmed ID: 38560893
NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development.
The Journal of clinical investigation Apr, 2024 | Pubmed ID: 38652563
Belzutifan in Individuals with von Hippel-Lindau Retinal Hemangioblastomas: Institutional Experience and Review of the Literature.
Ocular oncology and pathology Sep, 2024 | Pubmed ID: 39224523
Exonic splice variant discovery using in vitro models of inherited retinal disease.
HGG advances Jan, 2025 | Pubmed ID: 39354715
Ghost vessels in the eye: Cell free choriocapillaris domains in atrophic age-related macular degeneration.
Experimental eye research Nov, 2024 | Pubmed ID: 39419369
Conditional Immortalization Using SV40 Large T Antigen and Its Effects on Induced Pluripotent Stem Cell Differentiation Toward Retinal Progenitor Cells.
Stem cells and development Jan, 2025 | Pubmed ID: 39611948
Elevation of Granulocyte Colony Stimulating Factor in Human AMD Donor RPE-Choroid.
Investigative ophthalmology & visual science Dec, 2024 | Pubmed ID: 39641748
Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration.
Acta biomaterialia Mar, 2025 | Pubmed ID: 39710218
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