JoVE Journal

Biochemistry

This content is Open Access.

وسيلة فعالة لتخليق Peptoids مع مونمرات مختلط ليسين من نوع / ارجينين من نوع وتقييم نشاطهم مكافحة يشماني

Transcript

A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

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Chapters in this video

0:05

Title

1:09

Synthesis of a Linear Peptoid

5:08

Side-chain Deprotection and Cleavage from Resin

6:32

Cytotoxicity Assay against Leishmania mexicana Axenic Amastigotes

9:12

Results: Synthesis and Characterization of Peptoids and Their Cytotoxicity to Leishmania mexicana

10:33

Conclusion

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