Donald M. Kuhn

Research and Development Service, Wayne State University School of Medicine

Affiliated withWayne State University School of Medicine

Research Area

Behavior

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2013

Other Publications

Article	Year
Mass mapping sites of nitration in tyrosine hydroxylase: random vs selective nitration of three tyrosine residues. Chemical research in toxicology\| PubMed ID: 12703971	2003
Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight ... The Journal of biological chemistry\| PubMed ID: 11834745	2002
Reduced nicotinamide nucleotides prevent nitration of tyrosine hydroxylase by peroxynitrite. Brain research\| PubMed ID: 11929639	2002
Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12040046	2002
Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress. The Journal of biological chemistry\| PubMed ID: 12376535	2002
Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage? The Journal of biological chemistry\| PubMed ID: 12771134	2003
Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide. Molecular pharmacology\| PubMed ID: 14500751	2003
Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment--an oligonucleotide microarray approach. Journal of neurochemistry\| PubMed ID: 14690526	2004
Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. Journal of neurochemistry\| PubMed ID: 15009677	2004
Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons? Journal of neurochemistry\| PubMed ID: 15086510	2004
Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15163680	2004
Microglial activation is a pharmacologically specific marker for the neurotoxic amphetamines. Neuroscience letters\| PubMed ID: 15337264	2004
Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine. Journal of neurochemistry\| PubMed ID: 15686480	2005
Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15718289	2005
MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain research\| PubMed ID: 15987631	2005
S-thiolation of tyrosine hydroxylase by reactive nitrogen species in the presence of cysteine or glutathione. Antioxidants & redox signaling\| PubMed ID: 15998241	2005
Gene expression profile of activated microglia under conditions associated with dopamine neuronal damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16384912	2006
Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. Journal of neurochemistry\| PubMed ID: 16405505	2006
Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Brain research\| PubMed ID: 16581041	2006
MDMA and fenfluramine reduce L-DOPA-induced dyskinesia via indirect 5-HT1A receptor stimulation. The European journal of neuroscience\| PubMed ID: 16817869	2006
Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: relationship to methamphetamine-induced nerve ending damage. Annals of the New York Academy of Sciences\| PubMed ID: 17105901	2006
Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II. Journal of neurochemistry\| PubMed ID: 17727633	2007
The newly synthesized pool of dopamine determines the severity of methamphetamine-induced neurotoxicity. Journal of neurochemistry\| PubMed ID: 18088364	2008
A serotonergic system in veins: serotonin transporter-independent uptake. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18322152	2008
Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling. Journal of neurochemistry\| PubMed ID: 18410508	2008
Dopamine disposition in the presynaptic process regulates the severity of methamphetamine-induced neurotoxicity. Annals of the New York Academy of Sciences\| PubMed ID: 18991856	2008
Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity. Journal of neurochemistry\| PubMed ID: 19457119	2009
Soman increases neuronal COX-2 levels: possible link between seizures and protracted neuronal damage. Neurotoxicology\| PubMed ID: 20600289	2010
Potential mechanisms underlying anxiety and depression in Parkinson's disease: consequences of l-DOPA treatment. Neuroscience and biobehavioral reviews\| PubMed ID: 20615430	2011
The role of endogenous serotonin in methamphetamine-induced neurotoxicity to dopamine nerve endings of the striatum. Journal of neurochemistry\| PubMed ID: 20722968	2010
MDMA administration decreases serotonin but not N-acetylaspartate in the rat brain. Neurotoxicology\| PubMed ID: 20800616	2010
Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. Journal of neurochemistry\| PubMed ID: 21105877	2011
A mouse model of human repetitive mild traumatic brain injury. Journal of neuroscience methods\| PubMed ID: 21930157	2012
Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum. Journal of neurochemistry\| PubMed ID: 22191803	2012
Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. Journal of neurochemistry\| PubMed ID: 22443164	2012
Altered gene expression in cultured microglia in response to simulated blast overpressure: possible role of pulse duration. Neuroscience letters\| PubMed ID: 22698585	2012
Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility. Reproduction (Cambridge, England)\| PubMed ID: 23028123	2012
Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. PloS one\| PubMed ID: 23139830	2012
Mephedrone does not damage dopamine nerve endings of the striatum, but enhances the neurotoxicity of methamphetamine, amphetamine, and MDMA. Journal of neurochemistry\| PubMed ID: 23205838	2013
Nucleus accumbens invulnerability to methamphetamine neurotoxicity. ILAR journal / National Research Council, Institute of Laboratory Animal Resources\| PubMed ID: 23382149	2011
Effects of combined treatment with mephedrone and methamphetamine or 3,4-methylenedioxymethamphetamine on serotonin nerve endings of the hippocampus. Life sciences\| PubMed ID: 23892197	2013
Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 24336886	2013