Emily M. Mace

A dual role for talin in NK cell cytotoxicity: activation of LFA-1-mediated cell adhesion and polarization of NK cells.

Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells.

The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17.

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse.

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.

Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity.

Multiple distinct NK-cell synapses.

Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands.

Dual channel STED nanoscopy of lytic granules on actin filaments in natural killer cells.

NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence.

CD2 promotes human natural killer cell membrane nanotube formation.

New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques.

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.

Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling.

Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.

Cell biological steps and checkpoints in accessing NK cell cytotoxicity.