Alain Baulard

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system.

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.

Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.

EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator.

Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis.

Cloning, expression, and purification of the 27 kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis.

Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis.

[Doping in the peloton of antituberculosis drugs].

Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMR.

Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis.

Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria.

Ethambutol-induced alterations in Mycobacterium bovis BCG imaged by atomic force microscopy.

Chemical force microscopy of single live cells.

Antibody response in pulmonary tuberculosis against recombinant 27kDa (MPT51, Rv3803c) protein of Mycobacterium tuberculosis.

Direct measurement of hydrophobic forces on cell surfaces using AFM.

Organization of the mycobacterial cell wall: a nanoscale view.

Molecular genetics of para-aminosalicylic acid resistance in clinical isolates and spontaneous mutants of Mycobacterium tuberculosis.

Molecular mapping of lipoarabinomannans on mycobacteria.

Synthetic EthR inhibitors boost antituberculous activity of ethionamide.

Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator.

Ethionamide boosters: synthesis, biological activity, and structure-activity relationships of a series of 1,2,4-oxadiazole EthR inhibitors.

MALDI imaging techniques dedicated to drug-distribution studies.

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors.

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.

Tuberculosis: the drug development pipeline at a glance.

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.

Mechanism of competence activation by the ComRS signalling system in streptococci.

Structural and docking studies of potent ethionamide boosters.