Martin McMahon

Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells.

De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells.

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells.

Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway.

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.

DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry.

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.

Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion.

Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.

Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT.

Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.

Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines.

Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines.

Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?

Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells.

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors.

A model of intussusceptive angiogenesis.

Meeting report: fourth international congress of the Society for Melanoma Research.

Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival.

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.

Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008.

Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

Characterization of melanoma cells capable of propagating tumors from a single cell.

Resiliency and vulnerability in the HER2-HER3 tumorigenic driver.

RAF translocations expand cancer targets.

Parsing out the complexity of RAF inhibitor resistance.

Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies.

Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse.

Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.

β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas.

MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E.

E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor.

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.

Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.

Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity.

B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer.

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.

Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.

Elucidating distinct roles for NF1 in melanomagenesis.

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance.

Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.

Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.

Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation.

Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.

Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720.

Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.

BRAFV600E Cooperates with PI3'-Kinase Signaling, Independent of AKT, to Regulate Melanoma Cell Proliferation.