Tumor Microenvironment and Metastasis Program
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CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) May, 2010 | Pubmed ID: 20400704
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
The New England journal of medicine Jan, 2003 | Pubmed ID: 12529460
Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.
Cancer biology & therapy Jul-Aug, 2003 | Pubmed ID: 14508119
Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells.
Cancer research Mar, 2004 | Pubmed ID: 15026360
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Nature medicine Sep, 2004 | Pubmed ID: 15322536
Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A.
Nature medicine Sep, 2004 | Pubmed ID: 15334073
Vascular leukocytes contribute to tumor vascularization.
Blood Jan, 2005 | Pubmed ID: 15358628
HSV oncolytic therapy upregulates interferon-inducible chemokines and recruits immune effector cells in ovarian cancer.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2005 | Pubmed ID: 15925544
Oncolytic HSV exerts direct antiangiogenic activity in ovarian carcinoma.
Human gene therapy Jun, 2005 | Pubmed ID: 15960607
Immunotherapy for gynaecological malignancies.
Expert opinion on biological therapy Sep, 2005 | Pubmed ID: 16120050
Use of immuno-LCM to identify the in situ expression profile of cellular constituents of the tumor microenvironment.
Cancer biology & therapy Jun, 2006 | Pubmed ID: 16627987
Direct vaccination with tumor cells killed with ICP4-deficient HSVd120 elicits effective antitumor immunity.
Cancer biology & therapy Jul, 2006 | Pubmed ID: 16861891
Vascular leukocytes: a population with angiogenic and immunossuppressive properties highly represented in ovarian cancer.
Advances in experimental medicine and biology , 2007 | Pubmed ID: 17191386
Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.
Cancer research May, 2007 | Pubmed ID: 17510407
Role of vascular leukocytes in ovarian cancer neovascularization.
Advances in experimental medicine and biology , 2008 | Pubmed ID: 18546635
PILAR is a novel modulator of human T-cell expansion.
Blood Aug, 2008 | Pubmed ID: 18550855
Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity.
Cancer research Sep, 2008 | Pubmed ID: 18768667
Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer.
Journal of translational medicine , 2009 | Pubmed ID: 19545375
CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion.
Cancer research Aug, 2009 | Pubmed ID: 19602595
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity.
The Journal of clinical investigation Aug, 2009 | Pubmed ID: 19620771
In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells.
Cancer research Sep, 2009 | Pubmed ID: 19738057
Nanomolecular targeting of dendritic cells for ovarian cancer therapy.
Future oncology (London, England) Oct, 2009 | Pubmed ID: 19852731
Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes.
Cell cycle (Georgetown, Tex.) Jan, 2010 | Pubmed ID: 20023378
Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.
The Journal of experimental medicine Mar, 2010 | Pubmed ID: 20212068
Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2010 | Pubmed ID: 20682703
Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.
Clinical & developmental immunology , 2010 | Pubmed ID: 21076522
CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.
Oncotarget Sep, 2010 | Pubmed ID: 21113407
It never rains but it pours: potential role of butyrophilins in inhibiting anti-tumor immune responses.
Cell cycle (Georgetown, Tex.) Feb, 2011 | Pubmed ID: 21270530
Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer.
Cancer research Apr, 2012 | Pubmed ID: 22307839
Ovarian cancer progression is controlled by phenotypic changes in dendritic cells.
The Journal of experimental medicine Mar, 2012 | Pubmed ID: 22351930
Double agents in the war on cancer: leukocytes govern ovarian cancer progression.
Oncotarget Mar, 2012 | Pubmed ID: 22538964
Mast cells impair the development of protective anti-tumor immunity.
Cancer immunology, immunotherapy : CII Dec, 2012 | Pubmed ID: 22684520
Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?
American journal of physiology. Lung cellular and molecular physiology Sep, 2012 | Pubmed ID: 22821996
Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy.
Integrative biology : quantitative biosciences from nano to macro Jan, 2013 | Pubmed ID: 22935885
Editorial: A clear vision needs some balance.
Journal of leukocyte biology Nov, 2012 | Pubmed ID: 23118443
Anti-tumor immunity: myeloid leukocytes control the immune landscape.
Cellular immunology Jul-Aug, 2012 | Pubmed ID: 23121972
Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles.
Oncoimmunology Sep, 2012 | Pubmed ID: 23162774
Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment.
Cancer research Jul, 2013 | Pubmed ID: 23704211
Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition.
Cell cycle (Georgetown, Tex.) Jul, 2013 | Pubmed ID: 23759589
A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.
Journal of cellular physiology Jan, 2014 | Pubmed ID: 23765988
Modulating the tumor immune microenvironment as an ovarian cancer treatment strategy.
Expert review of obstetrics & gynecology Sep, 2012 | Pubmed ID: 24039628
Pathological Mobilization and Activities of Dendritic Cells in Tumor-Bearing Hosts: Challenges and Opportunities for Immunotherapy of Cancer.
Frontiers in immunology , 2013 | Pubmed ID: 24339824
Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors.
Nanomedicine : nanotechnology, biology, and medicine Feb, 2014 | Pubmed ID: 24566274
Melanie R. Rutkowski*,1,
Michael J. Allegrezza*,1,
Nikolaos Svoronos1,
Amelia J. Tesone1,
Tom L. Stephen1,
Alfredo Perales-Puchalt1,
Jenny Nguyen1,
Paul J. Zhang2,
Steven N. Fiering3,
Julia Tchou4,5,6,
Jose R. Conejo-Garcia1
1Tumor Microenvironment and Metastasis Program, Wistar Institute,
2Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania,
3Department of Microbiology and Immunology and Department of Genetics, Geisel School of Medicine at Dartmouth,
4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania,
5Rena Rowan Breast Center, Abramson Cancer Center, University of Pennsylvania,
6Center for Advanced Medicine, University of Pennsylvania
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