Friedemann Weber

Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon.

Antigenic drift, antigenic shift and interferon antagonists: how bunyaviruses counteract the immune system.

Novel gene product of Thogoto virus segment 6 codes for an interferon antagonist.

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs.

Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids.

Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death.

Viral evasion of the interferon system: old viruses, new tricks.

Inhibition of Dugbe nairovirus replication by human MxA protein.

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein.

Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist.

High-efficiency detection of severe acute respiratory syndrome virus genetic material.

NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription.

Thogoto virus ML protein suppresses IRF3 function.

Inverse interference: how viruses fight the interferon system.

Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.

Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs.

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.

The interferon response circuit: induction and suppression by pathogenic viruses.

A target on the move: innate and adaptive immune escape strategies of hepatitis C virus.

Induction of interferon synthesis by the PKR-inhibitory VA RNAs of adenoviruses.

Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence.

Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus.

Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses.

Neurons produce type I interferon during viral encephalitis.

Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells.

Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.

The intracellular sites of early replication and budding of SARS-coronavirus.

Viral suppression of the interferon system.

La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts.

Interferon, Mx, and viral countermeasures.

Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines.

Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter.

Interaction of hepatitis C virus with the type I interferon system.

Interferon and cytokine responses to SARS-coronavirus infection.

Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.

Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response.

T7 RNA polymerase-dependent and -independent systems for cDNA-based rescue of Rift Valley fever virus.

The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB.

Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zonoosis.

Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.

Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses.

Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus.

Electron cryo-microscopy and single-particle averaging of Rift Valley fever virus: evidence for GN-GC glycoprotein heterodimers.

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.

Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation.

Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor.

Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.

Species-independent bioassay for sensitive quantification of antiviral type I interferons.

Molecular biology of rift valley Fever virus.

La Crosse virus (LACV) Gc fusion peptide mutants have impaired growth and fusion phenotypes, but remain neurotoxic.

Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles.

Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.

Virus-like particles expressing the nucleocapsid gene as an efficient vaccine against Rift Valley fever virus.

Toscana virus induces interferon although its NSs protein reveals antagonistic activity.

Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.

Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II.

Interferon interplay helps tissue cells to cope with SARS-coronavirus infection.

Old World hantaviruses do not produce detectable amounts of dsRNA in infected cells and the 5' termini of their genomic RNAs are monophosphorylated.

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.

Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines.

Hiding from intracellular pattern recognition receptors, a passive strategy of flavivirus immune evasion.

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

Bunyaviruses and the type I interferon system.

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.

Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication.

Regulatory, biosafety and safety challenges for novel cells as substrates for human vaccines.

Reverse genetics of SARS-related coronavirus using vaccinia virus-based recombination.

Viral immune modulators perturb the human molecular network by common and unique strategies.

Structure of Crimean-Congo hemorrhagic fever virus nucleoprotein: superhelical homo-oligomers and the role of caspase-3 cleavage.

Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines.

Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus.

Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling.

Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein.

Systems to establish bunyavirus genome replication in the absence of transcription.

IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock.

Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity.

Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.

Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein.

RIG-I-like receptors and negative-strand RNA viruses: RLRly bird catches some worms.

Segmented negative-strand RNA viruses and RIG-I: divide (your genome) and rule.