Optics Division,
Athinoula A. Martinos Center for Biomedical Imaging,
Department of Radiology,
Optics Division, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology
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Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects.
Journal of applied physiology (Bethesda, Md. : 1985) Jan, 2002 | Pubmed ID: 11744680
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model.
Nature medicine Feb, 2002 | Pubmed ID: 11821897
Frontal lobe activation during object permanence: data from near-infrared spectroscopy.
NeuroImage Aug, 2002 | Pubmed ID: 12202098
Non-invasive neuroimaging using near-infrared light.
Biological psychiatry Oct, 2002 | Pubmed ID: 12372658
A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation.
NeuroImage Oct, 2002 | Pubmed ID: 12377147
Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation.
Optics letters Jan, 2003 | Pubmed ID: 12656525
Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters.
NeuroImage Apr, 2003 | Pubmed ID: 12725763
Fluorescence optical diffusion tomography.
Applied optics Jun, 2003 | Pubmed ID: 12790460
Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging.
Applied optics Jun, 2003 | Pubmed ID: 12790461
Optode positional calibration in diffuse optical tomography.
Applied optics Jun, 2003 | Pubmed ID: 12790466
Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation.
Physics in medicine and biology May, 2003 | Pubmed ID: 12812454
Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.
Neuron Jul, 2003 | Pubmed ID: 12873390
Tomographic optical breast imaging guided by three-dimensional mammography.
Applied optics Sep, 2003 | Pubmed ID: 12962399
Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging.
Psychophysiology Jul, 2003 | Pubmed ID: 14570163
Volumetric diffuse optical tomography of brain activity.
Optics letters Nov, 2003 | Pubmed ID: 14587815
Noninvasive measurement of neuronal activity with near-infrared optical imaging.
NeuroImage Jan, 2004 | Pubmed ID: 14741675
Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography.
Optics letters Feb, 2004 | Pubmed ID: 14759043
Fluorescence optical diffusion tomography using multiple-frequency data.
Journal of the Optical Society of America. A, Optics, image science, and vision Jun, 2004 | Pubmed ID: 15191186
Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jul, 2004 | Pubmed ID: 15241182
Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media.
Optics letters Jul, 2004 | Pubmed ID: 15309848
Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy.
NeuroImage , 2004 | Pubmed ID: 15501097
Pronounced hypoperfusion during spreading depression in mouse cortex.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Oct, 2004 | Pubmed ID: 15529018
Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2005 | Pubmed ID: 15734797
Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging.
Applied optics Apr, 2005 | Pubmed ID: 15813518
Optimal linear inverse solution with multiple priors in diffuse optical tomography.
Applied optics Apr, 2005 | Pubmed ID: 15813531
Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function.
Applied optics Apr, 2005 | Pubmed ID: 15813532
Using near-infrared spectroscopy to assess neural activation during object processing in infants.
Journal of biomedical optics Jan-Feb, 2005 | Pubmed ID: 15847576
Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation.
Journal of biomedical optics Jan-Feb, 2005 | Pubmed ID: 15847579
Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging.
Journal of biomedical optics Jan-Feb, 2005 | Pubmed ID: 15847580
Coregistered tomographic x-ray and optical breast imaging: initial results.
Journal of biomedical optics Mar-Apr, 2005 | Pubmed ID: 15910106
Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex.
NeuroImage Aug, 2005 | Pubmed ID: 15925522
Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin.
NeuroImage Oct, 2005 | Pubmed ID: 16084112
A haemodynamic response function model in spatio-temporal diffuse optical tomography.
Physics in medicine and biology Oct, 2005 | Pubmed ID: 16177494
Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information.
Physics in medicine and biology Sep, 2005 | Pubmed ID: 16177522
Dynamic physiological modeling for functional diffuse optical tomography.
NeuroImage Mar, 2006 | Pubmed ID: 16242967
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Aug, 2006 | Pubmed ID: 16340958
Fluorescence-lifetime-based tomography for turbid media.
Optics letters Dec, 2005 | Pubmed ID: 16389827
Physiological system identification with the Kalman filter in diffuse optical tomography.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention , 2005 | Pubmed ID: 16686015
Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imaging.
Applied optics Jul, 2006 | Pubmed ID: 16799690
Time-gated optical system for depth-resolved functional brain imaging.
Journal of biomedical optics Jul-Aug, 2006 | Pubmed ID: 16965165
Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism May, 2007 | Pubmed ID: 17033691
Assessing infants' cortical response to speech using near-infrared spectroscopy.
NeuroImage Jan, 2007 | Pubmed ID: 17045812
Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging.
Applied optics Nov, 2006 | Pubmed ID: 17068557
Diffuse optical imaging of the whole head.
Journal of biomedical optics Sep-Oct, 2006 | Pubmed ID: 17092156
A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jun, 2007 | Pubmed ID: 17200678
Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging.
Journal of biomedical optics Nov-Dec, 2006 | Pubmed ID: 17212541
Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation.
NeuroImage Mar, 2007 | Pubmed ID: 17222567
Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations.
Journal of biomedical optics Jan-Feb, 2007 | Pubmed ID: 17343508
Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties.
Applied optics Apr, 2007 | Pubmed ID: 17356611
Assessment of infant brain development with frequency-domain near-infrared spectroscopy.
Pediatric research May, 2007 | Pubmed ID: 17413855
Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2007 | Pubmed ID: 17442830
Image reconstruction in optical tomography in the presence of coupling errors.
Applied optics May, 2007 | Pubmed ID: 17446924
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia.
Brain : a journal of neurology Jun, 2007 | Pubmed ID: 17468117
Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography.
Physics in medicine and biology Jun, 2007 | Pubmed ID: 17664563
Optical imaging of phonological processing in two distinct orthographies.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale Jan, 2008 | Pubmed ID: 17999056
A vascular anatomical network model of the spatio-temporal response to brain activation.
NeuroImage Apr, 2008 | Pubmed ID: 18289880
Comparison of frequency-domain and time-domain fluorescence lifetime tomography.
Optics letters Mar, 2008 | Pubmed ID: 18311295
Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia.
Stroke; a journal of cerebral circulation May, 2008 | Pubmed ID: 18340095
Coupling between somatosensory evoked potentials and hemodynamic response in the rat.
NeuroImage Jun, 2008 | Pubmed ID: 18420425
Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration.
Developmental science May, 2008 | Pubmed ID: 18466370
Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomography.
IEEE transactions on medical imaging Jun, 2008 | Pubmed ID: 18541483
Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model.
Human brain mapping May, 2009 | Pubmed ID: 18649348
Assessing the future of diffuse optical imaging technologies for breast cancer management.
Medical physics Jun, 2008 | Pubmed ID: 18649477
A time domain fluorescence tomography system for small animal imaging.
IEEE transactions on medical imaging Aug, 2008 | Pubmed ID: 18672432
Oxygen advection and diffusion in a three- dimensional vascular anatomical network.
Optics express Oct, 2008 | Pubmed ID: 18958033
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia.
Journal of biomedical optics Jul-Aug, 2008 | Pubmed ID: 19021335
Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system.
Journal of biomedical optics Sep-Oct, 2008 | Pubmed ID: 19021399
Direct estimation of evoked hemoglobin changes by multimodality fusion imaging.
Journal of biomedical optics Sep-Oct, 2008 | Pubmed ID: 19021411
Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser.
Optics express Dec, 2008 | Pubmed ID: 19065223
Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression.
IEEE transactions on medical imaging Jan, 2009 | Pubmed ID: 19116186
Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2008 | Pubmed ID: 19118167
Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation.
Journal of neuroscience methods Mar, 2009 | Pubmed ID: 19121336
Identifying cortical lateralization of speech processing in infants using near-infrared spectroscopy.
Developmental neuropsychology , 2009 | Pubmed ID: 19142766
Fast optical signal not detected in awake behaving monkeys.
NeuroImage Apr, 2009 | Pubmed ID: 19150500
Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition.
NeuroImage Jul, 2009 | Pubmed ID: 19286463
Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression.
Applied optics Apr, 2009 | Pubmed ID: 19340106
HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain.
Applied optics Apr, 2009 | Pubmed ID: 19340120
Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex.
Journal of neuroscience methods May, 2009 | Pubmed ID: 19428529
A cerebrovascular response model for functional neuroimaging including dynamic cerebral autoregulation.
Mathematical biosciences Aug, 2009 | Pubmed ID: 19442671
Time resolved fluorescence tomography of turbid media based on lifetime contrast.
Optics express Dec, 2006 | Pubmed ID: 19529654
Linear 3D reconstruction of time-domain diffuse optical imaging differential data: improved depth localization and lateral resolution.
Optics express Dec, 2007 | Pubmed ID: 19550930
Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.
Optics letters Jul, 2009 | Pubmed ID: 19572001
Anatomical atlas-guided diffuse optical tomography of brain activation.
NeuroImage Jan, 2010 | Pubmed ID: 19643185
Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life.
Human brain mapping Mar, 2010 | Pubmed ID: 19650140
Increased cerebral blood volume and oxygen consumption in neonatal brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Oct, 2009 | Pubmed ID: 19675563
Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia.
Journal of biomedical optics Jul-Aug, 2009 | Pubmed ID: 19725749
Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'.
Physiological measurement Oct, 2009 | Pubmed ID: 19767672
Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography.
Optics letters Oct, 2009 | Pubmed ID: 19838234
Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing units.
Optics express Oct, 2009 | Pubmed ID: 19997242
The Possible Role of CO(2) in Producing A Post-Stimulus CBF and BOLD Undershoot.
Frontiers in neuroenergetics , 2009 | Pubmed ID: 20027233
Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy.
Optics express Dec, 2009 | Pubmed ID: 20052157
Dendritic phosphorescent probes for oxygen imaging in biological systems.
ACS applied materials & interfaces Jun, 2009 | Pubmed ID: 20072726
Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jun, 2010 | Pubmed ID: 20087371
Quantitative cerebral blood flow with optical coherence tomography.
Optics express Feb, 2010 | Pubmed ID: 20174075
Laser speckle contrast imaging in biomedical optics.
Journal of biomedical optics Jan-Feb, 2010 | Pubmed ID: 20210435
The effect of different anesthetics on neurovascular coupling.
NeuroImage Jul, 2010 | Pubmed ID: 20350606
Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infants.
NeuroImage Nov, 2010 | Pubmed ID: 20561591
Dissociation of processing of featural and spatiotemporal information in the infant cortex.
NeuroImage Dec, 2010 | Pubmed ID: 20603218
Rapid volumetric angiography of cortical microvasculature with optical coherence tomography.
Optics letters Jan, 2010 | Pubmed ID: 20664667
Examining the phonological neighborhood density effect using near infrared spectroscopy.
Human brain mapping Sep, 2011 | Pubmed ID: 20690126
Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue.
Nature methods Sep, 2010 | Pubmed ID: 20693997
Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20696904
Lifetime-based tomographic multiplexing.
Journal of biomedical optics Jul-Aug, 2010 | Pubmed ID: 20799813
Spontaneous low-frequency oscillations in cerebral vessels: applications in carotid artery disease and ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Nov-Dec, 2010 | Pubmed ID: 20864356
Combined optical and X-ray tomosynthesis breast imaging.
Radiology Jan, 2011 | Pubmed ID: 21062924
Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Apr, 2011 | Pubmed ID: 21179069
Compositional-prior-guided image reconstruction algorithm for multi-modality imaging.
Biomedical optics express , 2010 | Pubmed ID: 21258460
Resting state functional connectivity of the whole head with near-infrared spectroscopy.
Biomedical optics express , 2010 | Pubmed ID: 21258470
Monte Carlo simulation of the spatial resolution and depth sensitivity of two-dimensional optical imaging of the brain.
Journal of biomedical optics Jan-Feb, 2011 | Pubmed ID: 21280912
Optical coherence tomography for the quantitative study of cerebrovascular physiology.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jun, 2011 | Pubmed ID: 21364599
Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling.
NeuroImage Jun, 2011 | Pubmed ID: 21385616
Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult.
Biomedical optics express , 2011 | Pubmed ID: 21412461
Multiphysics neuron model for cellular volume dynamics.
IEEE transactions on bio-medical engineering Oct, 2011 | Pubmed ID: 21659016
Laser speckle imaging in the spatial frequency domain.
Biomedical optics express Jun, 2011 | Pubmed ID: 21698018
Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels.
Biomedical optics express Jul, 2011 | Pubmed ID: 21750779
"Overshoot" of Oâ‚‚ is required to maintain baseline tissue oxygenation at locations distal to blood vessels.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2011 | Pubmed ID: 21940458
Short separation channel location impacts the performance of short channel regression in NIRS.
NeuroImage Feb, 2012 | Pubmed ID: 21945793
Haemoglobin oxygen saturation as a biomarker: the problem and a solution.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Nov, 2011 | Pubmed ID: 22006898
Cortical spreading depression impairs oxygen delivery and metabolism in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2012 | Pubmed ID: 22008729
Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response.
Journal of biomedical optics Oct, 2011 | Pubmed ID: 22029350
Quantification of the cortical contribution to the NIRS signal over the motor cortex using concurrent NIRS-fMRI measurements.
NeuroImage Oct, 2011 | Pubmed ID: 22036999
Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex.
Optics express Oct, 2011 | Pubmed ID: 22108978
The utility of near-infrared spectroscopy in the regression of low-frequency physiological noise from functional magnetic resonance imaging data.
NeuroImage Nov, 2011 | Pubmed ID: 22119653
Frontiers in optical imaging of cerebral blood flow and metabolism.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jan, 2012 | Pubmed ID: 22252238
Sava Sakadžić1,
Emmanuel Roussakis2,
Mohammad A. Yaseen1,
Emiri T. Mandeville3,
Vivek J. Srinivasan1,
Ken Arai3,
Svetlana Ruvinskaya1,
Weicheng Wu1,
Anna Devor1,4,
Eng H. Lo3,
Sergei A. Vinogradov2,
David A. Boas1
1Optics Division, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School,
2Department of Biochemistry and Biophysics, University of Pennsylvania,
3Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School,
4Departments of Neurosciences and Radiology, University of California
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